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Spontaneous Formati...
Spontaneous Formation of Ultrasmall Unilamellar Vesicles in Mixtures of an Amphiphilic Drug and a Phospholipid
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- Forooqi Motlaq, Vahid (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Gedda, Lars (författare)
- Uppsala universitet,Fysikalisk kemi
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- Edwards, Katarina (författare)
- Uppsala universitet,Fysikalisk kemi
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- Doutch, James (författare)
- STFC, ISIS Neutron & Muon Source, Rutherford Appleton Lab, Didcot OX11 0QX, England.
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- Bergström, L. Magnus (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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(creator_code:org_t)
- American Chemical Society (ACS), 2023
- 2023
- Engelska.
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Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 39:32, s. 11337-11344
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We have observed ultrasmall unilamellar vesicles, withdiametersof less than 20 nm, in mixtures of the tricyclic antidepressant drugamitriptyline hydrochloride (AMT) and the unsaturated zwitterionicphospholipid 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) in physiologicalsaline solution. The size and shape of spontaneously formed self-assembledaggregates have been characterized using complementary techniques,i.e., small-angle neutron and X-ray scattering (SANS and SAXS) andcryo-transmission electron microscopy (cryo-TEM). We observe rodlikemixed micelles in more concentrated samples that grow considerablyin length upon dilution, and a transition from micelles to vesiclesis observed as the concentration approaches the critical micelle concentrationof AMT. Unlike the micelles, the spontaneously formed vesicles decreasein size with each step of dilution, and ultrasmall unilamellar vesicles,with diameters as small as about 15 nm, were observed at the lowestconcentrations. The spontaneously formed ultrasmall unilamellar vesiclesmaintain their size for as long we have investigated them (i.e., severalmonths). To the best of our knowledge, such small vesicles have neverbefore been reported to form spontaneously in a biocompatible phospholipid-basedsystem. Most interestingly, the size of the vesicles was observedto be strongly dependent on the chemical structure of the phospholipid,and in mixtures of AMT and the phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine(DMPC), the vesicles were observed to be considerably larger in size.The self-assembly behavior in the phospholipid-drug surfactantsystem in many ways resembles the formation of equilibrium micellesand vesicles in mixed anionic/cationic surfactant systems.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
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