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  • Cannata, StefanoIRCCS, Dept Cardiothorac Surg, Unit Intervent Cardiol, UPMC,ISMETT,Mediterranean Inst Transplantat & Adv, Palermo, Italy. (author)

One-year outcomes after transcatheter aortic valve implantation with the latest-generation SAPIEN balloonexpandable valve : the S3U registry

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Europa Digital & Publishing,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-511126
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-511126URI
  • https://doi.org/10.4244/EIJ-D-22-01022DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Initial data about the performance of the new-generation SAPIEN 3 Ultra (S3U) valve are highly promising. However, evidence about the longer-term performance and safety of the S3U is scarce.Aims: We aimed to investigate the 1-year clinical and echocardiographic outcomes of transcatheter aortic valve implantation (TAVI) using the S3U compared with its predecessor, the SAPIEN 3 valve (S3).Methods: The SAPIEN 3 Ultra registry included consecutive patients who underwent transfemoral TAVI at 12 European centres with the S3U or S3 between October 2016 and December 2020. One-to-one propensity score (PS) matching was performed to account for differences in baseline characteristics. The primary outcomes of interest were all-cause death and the composite of all-cause death, disabling stroke and hospitalisation for heart failure at 1 year.Results: The overall study cohort encompassed 1,692 patients treated with either the S3U (n=519) or S3 (n=1,173). The PS-matched population had a total of 992 patients (496 per group). At 1 year, the rate of death from any cause was 4.9% in the S3U group and 6.3% in the S3 group (p=0.743). Similarly, there were no significant differences in the rates of the primary composite outcome (9.5% in the S3 group and 6.6% in the S3U group; p=0.162). The S3U was associated with lower rates of mild paravalvular leak (PVL) compared with the S3 (odds ratio 0.63, 95% confidence interval: 0.44 to 0.88; p<0.01). No significant differences in transprosthetic gradients were observed between the two groups.Conclusions: Compared with the S3, the S3U transcatheter heart valve was associated with similar 1-year clinical outcomes but reduced rates of mild PVL.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Gandolfo, CaterinaIRCCS, Dept Cardiothorac Surg, Unit Intervent Cardiol, UPMC,ISMETT,Mediterranean Inst Transplantat & Adv, Palermo, Italy. (author)
  • Ribichini, FlavioUniv Verona, Div Cardiol, Dept Med, Verona, Italy. (author)
  • Van Mieghem, NicolasErasmus Univ, Dept Cardiol, Ctr Thorax, Med Ctr, Rotterdam, Netherlands. (author)
  • Buccheri, SergioUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper(Swepub:uu)serbu677 (author)
  • Barbanti, MarcoAOU Policlin G Rodolico San Marco, Div Cardiol, Catania, Italy. (author)
  • Berti, SergioFdn CNR Reg Toscana G Monasterio, UOC Cardiol Diagnost & Interventist, Massa, Italy. (author)
  • Teles, Rui CampanteHosp Santa Cruz, Nova Med Sch, CHLO, CEDOC, Lisbon, Portugal. (author)
  • Bartorelli, Antonio L.Univ Milan, Ctr Cardiol Monzino IRCCS, Milan, Italy. (author)
  • Musumeci, GiuseppeMauriziano Hosp, Dept Cardiol, Turin, Italy. (author)
  • Piva, TommasoOsped Riuniti Ancona, Intervent Cardiol, Ancona, Italy. (author)
  • Nombela-Franco, LuisHosp Clin San Carlos, Cardiovasc Inst, Inst Invest Sanitaria San Carlos, Madrid, Spain. (author)
  • La Spina, KettyIRCCS, Dept Cardiothorac Surg, Unit Intervent Cardiol, UPMC,ISMETT,Mediterranean Inst Transplantat & Adv, Palermo, Italy. (author)
  • Palmerini, TullioIRCCS Univ Hosp Bologna, Cardio Thorac Vasc Dept, Cardiol Unit, Policlin S Orsola, Bologna, Italy. (author)
  • Adrichem, RikErasmus Univ, Dept Cardiol, Ctr Thorax, Med Ctr, Rotterdam, Netherlands.;Uppsala Univ Hosp, Dept Med Sci, Uppsala, Sweden. (author)
  • Esposito, AugustoFdn CNR Reg Toscana G Monasterio, UOC Cardiol Diagnost & Interventist, Massa, Italy. (author)
  • Lopes, PedroHosp Santa Cruz, Nova Med Sch, CHLO, CEDOC, Lisbon, Portugal. (author)
  • Olivares, PaoloUniv Milan, Ctr Cardiol Monzino IRCCS, Milan, Italy. (author)
  • Annibali, GianmarcoMauriziano Hosp, Dept Cardiol, Turin, Italy. (author)
  • Nicolini, ElisaOsped Riuniti Ancona, Intervent Cardiol, Ancona, Italy. (author)
  • Marroquin, LuisHosp Clin San Carlos, Cardiovasc Inst, Inst Invest Sanitaria San Carlos, Madrid, Spain. (author)
  • Tamburino, CorradoFdn CNR Reg Toscana G Monasterio, UOC Cardiol Diagnost & Interventist, Massa, Italy. (author)
  • Tarantini, GiuseppeUniv Padua, Dept Cardiac Thorac Vasc Sci & Publ Hlth, Intervent Cardiol Unit, Padua, Italy. (author)
  • Saia, FrancescoIRCCS Univ Hosp Bologna, Cardio Thorac Vasc Dept, Cardiol Unit, Policlin S Orsola, Bologna, Italy. (author)
  • IRCCS, Dept Cardiothorac Surg, Unit Intervent Cardiol, UPMC,ISMETT,Mediterranean Inst Transplantat & Adv, Palermo, Italy.Univ Verona, Div Cardiol, Dept Med, Verona, Italy. (creator_code:org_t)

Related titles

  • In:EuroIntervention: Europa Digital & Publishing18:17, s. 1418-+1774-024X1969-6213

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