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Mortality risk fact...
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Brito-Zerón, PilarSanitas Digital Hosp, Autoimmune Dis Unit, Res & Innovat Grp Autoimmune Dis, Hosp CIMA Ctr Med Milenium Balmes Snitas, Barcelona, Spain.,Hospital CIMA
(author)
Mortality risk factors in primary Sjögren syndrome : a real-world, retrospective, cohort study
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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Elsevier,2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-511623
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-511623URI
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https://doi.org/10.1016/j.eclinm.2023.102062DOI
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https://lup.lub.lu.se/record/74639d98-6f72-43bd-91de-4c25e8119d8dURI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Title in Web of Science: Mortality risk factors in primary Sjogren syndrome: a real-world, retrospective, cohort study
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BackgroundWhat baseline predictors would be involved in mortality in people with primary Sjögren syndrome (SjS) remains uncertain. This study aimed to investigate the baseline characteristics collected at the time of diagnosis of SjS associated with mortality and to identify mortality risk factors for all-cause death and deaths related to systemic SjS activity measured by the ESSDAI score.MethodsIn this international, real-world, retrospective, cohort study, we retrospectively collected data from 27 countries on mortality and causes of death from the Big Data Sjögren Registry. Inclusion criteria consisted of fulfilling 2002/2016 SjS classification criteria, and exclusion criteria included chronic HCV/HIV infections and associated systemic autoimmune diseases. A statistical approach based on a directed acyclic graph was used, with all-cause and Sjögren-related mortality as primary endpoints. The key determinants that defined the disease phenotype at diagnosis (glandular, systemic, and immunological) were analysed as independent variables.FindingsBetween January 1st, 2014 and December 31, 2023, data from 11,372 patients with primary SjS (93.5% women, 78.4% classified as White, mean age at diagnosis of 51.1 years) included in the Registry were analysed. 876 (7.7%) deaths were recorded after a mean follow-up of 8.6 years (SD 7.12). Univariate analysis of prognostic factors for all-cause death identified eight Sjögren-related variables (ocular and oral tests, salivary biopsy, ESSDAI, ANA, anti-Ro, anti-La, and cryoglobulins). The multivariate CPH model adjusted for these variables and the epidemiological features showed that DAS-ESSDAI (high vs no high: HR = 1.68; 95% CI, 1.27–2.22) and cryoglobulins (positive vs negative: HR = 1.72; 95% CI, 1.22–2.42) were independent predictors of all-cause death. Of the 640 deaths with available information detailing the specific cause of death, 14% were due to systemic SjS. Univariate analysis of prognostic factors for Sjögren-cause death identified five Sjögren-related variables (oral tests, clinESSDAI, DAS-ESSDAI, ANA, and cryoglobulins). The multivariate competing risks CPH model adjusted for these variables and the epidemiological features showed that oral tests (abnormal vs normal results: HR = 1.38; 95% CI, 1.01–1.87), DAS-ESSDAI (high vs no high: HR = 1.55; 95% CI, 1.22–1.96) and cryoglobulins (positive vs negative: HR = 1.52; 95% CI, 1.16–2) were independent predictors of SjS-related death.InterpretationThe key mortality risk factors at the time of SjS diagnosis were positive cryoglobulins and a high systemic activity scored using the ESSDAI, conferring a 2-times increased risk of all-cause and SjS-related death. ESSDAI measurement and cryoglobulin testing should be considered mandatory when an individual is diagnosed with SjS.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Flores-Chávez, AlejandraHosp Clin Barcelona, Dept Autoimmune Dis, ICMiD, Barcelona, Spain.,Hospital Clínic of Barcelona
(author)
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Horváth, Ildiko FannyUniv Debrecen, Fac Med, Div Clin Immunol, Debrecen, Hungary.,University of Debrecen
(author)
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Rasmussen, AstridOklahoma Med Res Fdn, Genes & Human Dis Res Program, Oklahoma City, OK USA.,Oklahoma Medical Research Foundation
(author)
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Li, XiaomeiUniv Sci & Technol China, Affiliated Hosp USTC 1, Dept Rheumatol & Immunol, Anhui Prov Hosp, Hefei, Peoples R China.,University of Science and Technology of China
(author)
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Olsson, PeterLund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-pol
(author)
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Vissink, ArjanUniv Groningen, Univ Med Ctr Groningen, Dept Oral & Maxillofacial Surger, Groningen, Netherlands.,University of Groningen
(author)
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Priori, RobertaSapienza Univ Rome, Dept Internal Med & Med Specialties, Rheumatol Clin, Rome, Italy.;St Camillus Int Univ Hlth Sci, UniCamillus, Rome, Italy.,Sapienza University of Rome
(author)
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Armagan, BerkanHacettepe Univ, Fac Med, Dept Internal Med, Div Rheumatol, Ankara, Turkiye.,Hacettepe University
(author)
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Hernandez-Molina, GabrielaInst Nacl Ciencias Med & Nutr Salvador Zubrican, Immunol & Rheumatol Dept, Mexico City, Mexico.,Instituto Nacional de Ciencias Médicas y Nutrición
(author)
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Praprotnik, SonjaUniv Med Ctr, Dept Rheumatol, Ljubljana, Slovenia.,University Medical Centre Ljubljana
(author)
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Quartuccio, LucaUniv Hosp St Maria Misericordia, Dept Med & Biol Sci, Clin Rheumatol, Udine, Italy.
(author)
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Inanc, Nevsun
(author)
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Özkiziltas, BurcugülGazi Univ, Dept Internal Med, Div Rheumatol, Sch Med, Ankara, Turkiye.
(author)
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Bartoloni, ElenaUniv Perugia, Dept Med, Rheumatol Unit, Perugia, Italy.
(author)
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Sebastian, AgataWroclaw Med Hosp, Dept Rheumatol & Internal Med, Wroclaw, Poland.
(author)
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Romão, Vasco C.Ctr Hosp Univ Lisboa Norte, Lisbon, Portugal.
(author)
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Solans, RoserHosp Valle De Hebron, Dept Internal Med, Barcelona, Spain.
(author)
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Pasoto, Sandra G.Univ Sao Paulo, Hosp Clin HCFMUSP, Rheumatol Div, Fac Med, Sao Paulo, Brazil.
(author)
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Rischmueller, MaureenUniv Adelaide, Queen Elizabeth Hosp, Dept Rheumatol, Discipline Med, Adelaide, SA, Australia.
(author)
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Galisteo, CarlosHosp Parc Tauli, Dept Rheumatol, Barcelona, Spain.
(author)
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Suzuki, YasunoriKanazawa Univ Hosp, Div Rheumatol, Kanazawa, Ishikawa, Japan.
(author)
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Fernandes Moca Trevisani, VirginiaUniv Fed Sao Paulo, Div Hlth Based Evidence, Sao Paulo, Brazil.
(author)
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Fugmann, CeciliaUppsala universitet,Reumatologi(Swepub:uu)cecfu607
(author)
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González-García, AndrésHosp 12 Octubre, Dept Rheumatol, Madrid, Spain.
(author)
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Carubbi, FrancescoSan Salvatore Hosp, Dept Med, Internal Med & Nephrol Unit, Sulmona, Laquila, Italy.
(author)
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Jurcut, CiprianCarol Davila Cent Mil Emergency Hosp, Dept Internal Med, Bucharest, Romania.
(author)
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Shimizu, ToshimasaNagasaki Univ, Dept Immunol & Rheumatol, Div Adv Prevent Med Sci, Grad Sch Biomed Sci, Nagasaki, Japan.
(author)
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Retamozo, SoledadHosp Quiron Salud, Dept Rheumatol, Barcelona, Spain.
(author)
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Atzeni, FabiolaUniv Messina, IRCCS Galeazzi Orthoped Inst, Milan & Rheumatol Unit, Messina, Italy.
(author)
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Hofauer, BenediktTech Univ Munich, Otorhinolaryngol Head & Neck Surg, Munich, Germany.
(author)
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Melchor-Díaz, SheilaHosp 12 Octubre, Dept Rheumatol, Madrid, Spain.
(author)
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Gheita, TamerCairo Univ, Kasr Al Ainy Sch Med, Rheumatol Dept, Cairo, Egypt.
(author)
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López-Dupla, MiguelHosp Joan 23, Dept Internal Med, Tarragona, Spain.
(author)
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Fonseca-Aizpuru, EvaHosp Cabuenes, Dept Internal Med, Gijon, Spain.
(author)
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Giacomelli, RobertoUniv Aquila, Sch Med, Clin Unit Rheumatol, Laquila, Italy.
(author)
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Vázquez, MarcosHosp Clin, Dept Rheumatol, San Lorenzo, Paraguay.
(author)
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Consani, SandraUniv Republ UdelaR, Hosp Maciel, Internal Med, Montevideo, Uruguay.
(author)
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Akasbi, MiriamHosp Infanta Leonor, Dept Internal Med, Madrid, Spain.
(author)
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Nakamura, HidekiNihon Univ, Dept Med, Div Hematol & Rheumatol, Sch Med, Oyaguchi Kami Cho, Tokyo, Tokyo, Japan.
(author)
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Szántó, AntóniaUniv Debrecen, Fac Med, Div Clin Immunol, Debrecen, Hungary.
(author)
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Farris, A. DariseOklahoma Med Res Fdn, Genes & Human Dis Res Program, Oklahoma City, OK USA.
(author)
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Wang, LiUniv Sci & Technol China, Affiliated Hosp USTC 1, Dept Rheumatol & Immunol, Anhui Prov Hosp, Hefei, Peoples R China.
(author)
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Mandl, ThomasLund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-tma
(author)
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Gattamelata, AngelicaSapienza Univ Rome, Dept Internal Med & Med Specialties, Rheumatol Clin, Rome, Italy.
(author)
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Kilic, LeventHacettepe Univ, Fac Med, Dept Internal Med, Div Rheumatol, Ankara, Turkiye.
(author)
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Perdan Pirkmajer, KatjaUniv Med Ctr, Dept Rheumatol, Ljubljana, Slovenia.
(author)
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Abacar, KeremMarmara Univ, Sch Med, Istanbul, Turkiye.
(author)
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Tufan, AbdurrahmanGazi Univ, Dept Internal Med, Div Rheumatol, Sch Med, Ankara, Turkiye.
(author)
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de Vita, SalvatoreUniv Hosp St Maria Misericordia, Dept Med & Biol Sci, Clin Rheumatol, Udine, Italy.
(author)
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Bootsma, HendrikaUniv Groningen, Univ Med Ctr Groningen, Dept Rheumatol & Clin Immunol, Groningen, Netherlands.
(author)
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Ramos-Casals, ManuelHosp Clin Barcelona, Dept Autoimmune Dis, ICMiD, Barcelona, Spain.
(author)
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Sanitas Digital Hosp, Autoimmune Dis Unit, Res & Innovat Grp Autoimmune Dis, Hosp CIMA Ctr Med Milenium Balmes Snitas, Barcelona, Spain.Hospital CIMA
(creator_code:org_t)
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Sjögren Big Data Consortium
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Brito-Zerón, Pil ...
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Flores-Chávez, A ...
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Horváth, Ildiko ...
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Rasmussen, Astri ...
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Li, Xiaomei
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Olsson, Peter
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Vissink, Arjan
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Inanc, Nevsun
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Özkiziltas, Burc ...
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Bartoloni, Elena
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Sebastian, Agata
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Romão, Vasco C.
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Solans, Roser
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Pasoto, Sandra G ...
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Rischmueller, Ma ...
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Galisteo, Carlos
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Fugmann, Cecilia
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González-García, ...
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Jurcut, Ciprian
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Shimizu, Toshima ...
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Atzeni, Fabiola
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Hofauer, Benedik ...
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Fonseca-Aizpuru, ...
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Giacomelli, Robe ...
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Vázquez, Marcos
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Akasbi, Miriam
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Kilic, Levent
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Perdan Pirkmajer ...
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