Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease

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Luo, JiaoCopenhagen Univ Hosp, Dept Clin Biochem, Rigshosp, Copenhagen, Denmark. (författare)

Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease

Artikel/kapitelEngelska2023

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American Medical Association (AMA),2023
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LIBRIS-ID:oai:DiVA.org:uu-511629
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-511629URI
https://doi.org/10.1001/jamanetworkopen.2023.13734DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:153567997URI

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IMPORTANCE An estimated 40% of dementia is potentially preventable by modifying 12 risk factors throughout the life course. However, robust evidence for most of these risk factors is lacking. Effective interventions should target risk factors in the causal pathway to dementia.OBJECTIVE To comprehensively disentangle potentially causal aspects of modifiable risk factors for Alzheimer disease (AD) to inspire new drug targeting and improved prevention.DESIGN, SETTING, AND PARTICIPANTS This genetic association study was conducted using 2-sample univariable and multivariable mendelian randomization. Independent genetic variants associated with modifiable risk factors were selected as instrumental variables from genomic consortia. Outcome data for AD were obtained from the European Alzheimer & Dementia Biobank (EADB), generated on August 31, 2021. Main analyses were conducted using the EADB clinically diagnosed end point data. All analyses were performed between April 12 and October 27, 2022.EXPOSURES Genetically determined modifiable risk factors. MAIN OUTCOMES AND MEASURES Odds ratios (ORs) and 95% CIs for AD were calculated per 1-unit change of genetically determined risk factors.RESULTS The EADB-diagnosed cohort included 39106 participants with clinically diagnosed AD and 401577 control participants without AD. The mean age ranged from 72 to 83 years for participants with AD and 51 to 80 years for control participants. Among participants with AD, 54% to 75% were female, and among control participants, 48% to 60% were female. Genetically determined high-density lipoprotein (HDL) cholesterol concentrations were associated with increased odds of AD (OR per 1-SD increase, 1.10 [95% CI, 1.05-1.16]). Genetically determined high systolic blood pressure was associated with increased risk of AD after adjusting for diastolic blood pressure (OR per 10-mm Hg increase, 1.22 [95% CI, 1.02-1.46]). In a second analysis to minimize bias due to sample overlap, the entire UK Biobank was excluded from the EADB consortium; odds for AD were similar for HDL cholesterol (OR per 1-SD unit increase, 1.08 [95% CI, 1.02-1.15]) and systolic blood pressure after adjusting for diastolic blood pressure (OR per 10-mm Hg increase, 1.23 [95% CI, 1.01-1.50]).CONCLUSIONS AND RELEVANCE This genetic association study found novel genetic associations between high HDL cholesterol concentrations and high systolic blood pressure with higher risk of AD. These findings may inspire new drug targeting and improved prevention implementation.

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Thomassen, Jesper QvistCopenhagen Univ Hosp, Dept Clin Biochem, Rigshosp, Copenhagen, Denmark. (författare)
Bellenguez, CelineUniv Lille, Inst Pasteur Lille, INSERM, CHU Lille,Inst Pasteur Lille,U1167 RID Facteurs R, Lille, France. (författare)
Grenier-Boley, BenjaminUniv Lille, Inst Pasteur Lille, INSERM, CHU Lille,Inst Pasteur Lille,U1167 RID Facteurs R, Lille, France. (författare)
de Rojas, ItziarUniv Internac Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr & Memory Clin Fundacio ACE, Barcelona, Spain.;Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain. (författare)
Castillo, AtahualpaCardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales. (författare)
Parveen, KayenatUniv Cologne, Fac Med, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany.;Univ Hosp Cologne, Univ Cologne, Cologne, Germany.;Univ Hosp Bonn, Fac Med, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany. (författare)
Kuecuekali, FahriVIB Ctr Mol Neurol, Complex Genet Alzheimers Dis Grp, Antwerp, Belgium.;Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium. (författare)
Nicolas, AudeUniv Lille, Inst Pasteur Lille, INSERM, CHU Lille,Inst Pasteur Lille,U1167 RID Facteurs R, Lille, France. (författare)
Peters, OliverGerman Ctr Neurodegenerat Dis, Berlin, Germany.;Charite Univ med Berlin, Inst Psychiat & Psychotherapy, Berlin, Germany.;Free Univ Berlin, Humboldt Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Inst Psychiat & Psychotherapy, Berlin, Germany. (författare)
Schneider, AnjaGerman Ctr Neurodegenerat Dis, Bonn, Germany.;Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany. (författare)
Dichgans, MartinLudwig Maximilians Univ Munchen, Univ Hosp, Inst Stroke & Dementia Res, Munich, Germany.;German Ctr Neurodegenerat Dis, Munich, Germany.;Munich Cluster Syst Neurol, Munich, Germany. (författare)
Rujescu, DanMed Univ Vienna, Dept Psychiat & Psychotherapy, Vienna, Austria.;Med Univ Vienna, Comprehens Ctr Clin Neurosci & Mental Hlth, Vienna, Austria. (författare)
Scherbaum, NorbertUniv Duisburg Essen, Fac Med, Dept Psychiat & Psychotherapy, LVR Hosp Essen, Essen, Germany. (författare)
Juergen, DeckertUniv Hosp Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, Ctr Mental Hlth, Wurzburg, Germany. (författare)
Riedel-Heller, SteffiUniv Leipzig, Inst Social Med Occupat Hlth & Publ Hlth ISAP, Leipzig, Germany. (författare)
Hausner, LucreziaHeidelberg Univ, Fac Mannheim, Dept Geriatr Psychiat, Cent Inst Mental Hlth Mannheim, Heidelberg, Germany. (författare)
Porcel, Laura MolinaInst Investigaciones Biomed August Pi & Sunyer, Biobanc Hosp Clin, Neurol Tissue Bank, Barcelona, Spain.;Hosp Clin Barcelona, Dept Neurol, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain. (författare)
Duezel, EmrahGerman Ctr Neurodegenerat Dis, Magdeburg, Germany.;Otto Von Guericke Univ, Inst Cognit Neurol & Dementia Res, Magdeburg, Germany. (författare)
Grimmer, TimoTech Univ Munich, Sch Med, Dept Psychiat & Psychotherapy, Klinikum Rechts Isar, Munich, Germany. (författare)
Wiltfang, JensUniv Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany.;German Ctr Neurodegenerat Dis, Gottingen, Germany.;Inst Biomed, Dept Med Sci, Aveiro, Portugal. (författare)
Heilmann-Heimbach, StefanieUniv Bonn, Inst Human Genet, Sch Med, Bonn, Germany.;Univ Hosp Bonn, Bonn, Germany. (författare)
Moebus, SusanneUniv Duisburg Essen, Univ Hosp, Inst Urban Publ Hlth, Essen, Germany. (författare)
Tegos, ThomasAristotle Univ Thessaloniki, Sch Med, Dept Neurol 1, Thessaloniki, Greece. (författare)
Scarmeas, NikolaosNatl & Kapodistrian Univ Athens, Sch Med, Aiginit Hosp, Dept Neurol 1, Athens, Greece.;Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, Dept Neurol, Gertrude H Sergievsky Ctr, New York, NY USA. (författare)
Clarimon, JordiNatl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain.;Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, Dept Neurol, II B Sant Pau, Barcelona, Spain. (författare)
Moreno, FerminNatl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain.;Hosp Univ Donostia, Dept Neurol, San Sebastian, Spain.;Inst Biodonostia, Neurosci Area, San Sebastian, Spain. (författare)
Perez-Tur, JordiNatl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain.;Inst Biomed Valencia, Unitat Genet Mol, Consejo Super Invest Cient, Valencia, Spain.;Inst Invest Sanit La Fe, Unidad Mixta Neurol Genet, Valencia, Spain. (författare)
Bullido, Maria J.Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain.;UAM CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain.;Inst Invest Sanit Hosp La Paz, Madrid, Spain. (författare)
Pastor, PauUniv Hosp Germans Trias Pujol, Dept Neurol, Unit Neurodegenerat Dis, Barcelona, Spain.;Germans Trias Pujol Res Inst IGTP Badalona, Barcelona, Spain. (författare)
Sanchez-Valle, RaquelUniv Barcelona, Inst Investigac Biomed August Pi & Sunyer, Hosp Clin Barcelona, Alzheimers Dis & Other Cognit Disorders Unit,Serv, Barcelona, Spain. (författare)
Alvarez, VictoriaHosp Univ Cent Asturias, Lab Genet, Oviedo, Spain.;Inst Invest Sanit Principado Asturias, Asturias, Spain. (författare)
Boada, MerceNatl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain. (författare)
Garcia-Gonzalez, PabloUniv Internac Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr & Memory Clin Fundacio ACE, Barcelona, Spain. (författare)
Puerta, RaquelUniv Internac Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr & Memory Clin Fundacio ACE, Barcelona, Spain. (författare)
Mir, PabloNatl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain.;Univ Seville, Inst Biomed Sevilla, Hosp Univ Virgen Rocio,Consejo Super Invest Cient, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain. (författare)
Real, Luis M.Hosp Univ Valme, Unidad Clin Enfermedades Infecc Microbiol, Seville, Spain.;Univ Malaga, Fac Med, Dept Especialidades Quirurg Bioquim & Inmunol, Malaga, Spain. (författare)
Pinol-Ripoll, GerardHosp Univ Santa Maria Lleida, Unitat Trastorns Cognitius, Lleida, Spain.;Inst Recerca Biomed Lleida, Lleida, Spain. (författare)
Garcia-Alberca, Jose MariaNatl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain.;Inst Andaluz Neurociencia, Alzheimer Res Ctr Memory Clin, Malaga, Spain. (författare)
Royo, Jose LuisUniv Malaga, Fac Med, Dept Especialidades Quirurg Bioquim & Inmunol, Malaga, Spain. (författare)
Rodriguez-Rodriguez, EloyNatl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain.;Univ Cantabria, Marques Valdecilla Univ Hosp, Neurol Serv, Santander, Spain.;IDIVAL, Santander, Spain. (författare)
Soininen, HilkkaUniv Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland. (författare)
Kuulasmaa, TeemuUniv Eastern Finland, Inst Biomed, Kuopio, Finland. (författare)
de Mendonca, AlexandreUniv Lisbon, Fac Med, Lisbon, Portugal. (författare)
Mehrabian, ShimaMed Univ Sofia, Neurol Clin, UH Alexandrovska, Sofia, Bulgaria. (författare)
Hort, JakubCharles Univ Prague, Fac Med 2, Dept Neurol, Memory Clin, Prague, Czech Republic.;Motol Univ Hosp, Prague, Czech Republic.;St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic. (författare)
Vyhnalek, MartinCharles Univ Prague, Fac Med 2, Dept Neurol, Memory Clin, Prague, Czech Republic.;Motol Univ Hosp, Prague, Czech Republic.;St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic. (författare)
van der Lee, SvenSt Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic.;Vrije Univ Amsterdam, Genom Neurodegenerat Dis & Aging Human Genet, Amsterdam UMC, Locat VUmc, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam UMC, Locat VUmc,Neurol, Amsterdam, Netherlands.;Amsterdam Neurosci Neurodegenerat, Amsterdam, Netherlands. (författare)
Graff, CarolineKarolinska Institutet (författare)
Papenberg, GoranKarolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Res Ctr, Stockholm, Sweden.;Stockholm Univ, Stockholm, Sweden. (författare)
Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517 (författare)
Boland, AnneUniv Paris Saclay, Ctr Natl Rech Genom Humaine, CEA, Evry, France. (författare)
Bacq-Daian, DelphineUniv Paris Saclay, Ctr Natl Rech Genom Humaine, CEA, Evry, France. (författare)
Deleuze, Jean-FrancoisUniv Paris Saclay, Ctr Natl Rech Genom Humaine, CEA, Evry, France. (författare)
Nicolas, GaelUniv Rouen Normandie, Normandie Univ, Inserm U1245, Rouen, France.;CHU Rouen, Dept Genet, Rouen, France.;Ctr Natl Reference Malades Alzheimer Jeunes, Rouen, France. (författare)
Dufouil, CaroleUniv Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219,ISPED,CIC 1401 EC, Bordeaux, France.;CHU Bordeaux, Pole Sante Publ, Bordeaux, France. (författare)
Pasquier, FlorenceUniv Lille, CHU Lille, INSERM, Resources & Res Memory Ctr Distalz,UMR1172, Lille, France. (författare)
Hanon, OlivierUniv Paris, EA 4468, Hop Broca, Assistance Publ Hop Paris, Paris, France. (författare)
Debette, StephanieUniv Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, Bordeaux, France.;Bordeaux Univ Hosp, Dept Neurol, Bordeaux, France. (författare)
Gruenblatt, EdnaUniv Zurich, Psychiat Univ Hosp Zurich, Dept Child & Adolescent Psychiat & Psychotherapy, Zurich, Switzerland.;Univ Zurich, Neuroscience Ctr Zurich, Zurich, Switzerland.;Swiss Fed Inst Technol, Zurich, Switzerland.;Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland. (författare)
Popp, JuliusUniv Lausanne Hosp, Dept Psychiat, Old Age Psychiat, Lausanne, Switzerland.;Univ Hosp Psychiat Zurich, Dept Geriatr Psychiat, Zurich, Switzerland.;Univ Zurich, Dept Psychiat Psychotherapy & Psychosomat, Zurich, Switzerland. (författare)
Benussi, LuisaIRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Mol Markers Lab, Brescia, Italy. (författare)
Galimberti, DanielaOsped Policlin, Fdn IRCCS Ca Granda, Neurodegenerat Dis Unit, Milan, Italy.;Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy. (författare)
Arosio, BeatriceUniv Milan, Dept Clin Sci & Commun Hlth, Milan, Italy.;Fdn IRCCS Ca Granda Osped Maggiore Policli, Geriatr Unit, Milan, Italy. (författare)
Mecocci, PatriziaUniv Perugia, Inst Gerontol & Geriatr, Dept Med & Surg, Perugia, Italy.;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden. (författare)
Solfrizzi, VincenzoUniv Bari Aldo Moro, Interdisciplinary Dept Med, Geriatr Med & Memory Unit, Bari, Italy. (författare)
Parnetti, LucillaUniv Perugia, Neurol Sect, Lab Clin Neurochem, Ctr Memory Disturbances, Perugia, Italy. (författare)
Squassina, AlessioUniv Cagliari, Dept Biomed Sci, Sect Neurosci & Clin Pharmacol, Cagliari, Italy. (författare)
Tremolizzo, LucioHosp San Gerardo, Neurol Unit, Monza, Italy.;Univ Milano Bicocca, Milan, Italy. (författare)
Borroni, BarbaraUniv Brescia, Ctr Neurodegenerat Disorders, Neurol Unit, Dept Clin & Expt Sci, Brescia, Italy. (författare)
Nacmias, BenedettaUniv Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy.;IRCCS Fdn Don Carlo Gnocchi, Florence, Italy. (författare)
Sorbi, SandroUniv Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy.;IRCCS Fdn Don Carlo Gnocchi, Florence, Italy. (författare)
Caffarra, PaoloUniv Parma, Neurol Unit, Parma, Italy. (författare)
Seripa, DavideVito Fazzi Hosp, Dept Hematol & Stem Cell Transplant, Lab Adv Hematol Diagnost, Lecce, Italy. (författare)
Rainero, InnocenzoUniv Torino, Dept Neurosci Rita Levi Montalcini, Turin, Italy. (författare)
Daniele, AntonioUniv Cattolica Sacro Cuore, Dept Neurosci, Rome, Italy.;IRCCS Fdn Policlin Univ A Gemelli, Neurol Unit, Rome, Italy. (författare)
Masullo, CarloUniv Cattolica Sacro Cuore, Inst Neurol, Rome, Italy. (författare)
Spalletta, GianfrancoIRCCS Santa Lucia Fdn, Lab Neuropsychiat, Rome, Italy.;Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX USA. (författare)
Williams, JulieCardiff Univ, Sch Med, UK Dementia Res Inst Cardiff, Cardiff, Wales. (författare)
Amouyel, PhilippeUniv Lille, Inst Pasteur Lille, INSERM, CHU Lille,Inst Pasteur Lille,U1167 RID Facteurs R, Lille, France. (författare)
Jessen, FrankUniv Cologne, Fac Med, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany.;Univ Hosp Cologne, Univ Cologne, Cologne, Germany.;German Ctr Neurodegenerat Dis, Bonn, Germany.;Univ Cologne, Cluster Excellence Cellular Stress Responses Agin, Cologne, Germany. (författare)
Kehoe, PatrickUniv Bristol, Bristol Med Sch, Translat Hlth Sci, Bristol, England. (författare)
Magda, TsolakiAristotle Univ Thessaloniki, Sch Med, Dept Neurol 1, Thessaloniki, Greece.;Alzheimer Hellas, Thessaloniki, Greece. (författare)
Rossi, GiacominaFdn IRCCS Ist Neurol Carlo Besta, Unit Neurol Neuropathol, Milan, Italy. (författare)
Sanchez-Juan, PascualNatl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain.;Alzheimers Ctr Reina Sofia CIEN Fdn ISCIII, Madrid, Spain. (författare)
Sleegers, KristelVIB Ctr Mol Neurol, Complex Genet Alzheimers Dis Grp, Antwerp, Belgium.;Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium. (författare)
Ingelsson, MartinKarolinska Univ Hosp Solna, Unit Hereditary Dementias Theme Aging, Stockholm, Sweden.;Univ Hlth Network, Krembil Brain Inst, Toronto, ON, Canada.;Univ Toronto, Dept Med, Toronto, ON, Canada.;Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada. (författare)
Andreassen, Ole A.Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT Ctr, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway. (författare)
Hiltunen, MikkoUniv Cantabria, Marques Valdecilla Univ Hosp, Neurol Serv, Santander, Spain.;IDIVAL, Santander, Spain. (författare)
Van Duijn, CorneliaErasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England. (författare)
Sims, RebeccaCardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales. (författare)
van der Flier, Wiesje (författare)
Ruiz, AgustinUniv Internac Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr & Memory Clin Fundacio ACE, Barcelona, Spain.;Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain. (författare)
Ramirez, AlfredoUniv Cologne, Fac Med, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany.;Univ Hosp Cologne, Univ Cologne, Cologne, Germany.;Univ Hosp Bonn, Fac Med, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany.;German Ctr Neurodegenerat Dis, Bonn, Germany.;Univ Cologne, Cluster Excellence Cellular Stress Responses Agin, Cologne, Germany.;Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, Dept Psychiat, San Antonio, TX USA.;Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA. (författare)
Lambert, Jean-CharlesUniv Lille, Inst Pasteur Lille, INSERM, CHU Lille,Inst Pasteur Lille,U1167 RID Facteurs R, Lille, France. (författare)
Frikke-Schmidt, RuthCopenhagen Univ Hosp, Dept Clin Biochem, Rigshosp, Copenhagen, Denmark.;Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark. (författare)
Copenhagen Univ Hosp, Dept Clin Biochem, Rigshosp, Copenhagen, Denmark.Univ Lille, Inst Pasteur Lille, INSERM, CHU Lille,Inst Pasteur Lille,U1167 RID Facteurs R, Lille, France. (creator_code:org_t)

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Av författaren/redakt...: Luo, Jiao; Thomassen, Jespe ...; Bellenguez, Celi ...; Grenier-Boley, B ...; de Rojas, Itziar; Castillo, Atahua ...; visa fler...; Parveen, Kayenat; Kuecuekali, Fahr ...; Nicolas, Aude; Peters, Oliver; Schneider, Anja; Dichgans, Martin; Rujescu, Dan; Scherbaum, Norbe ...; Juergen, Deckert; Riedel-Heller, S ...; Hausner, Lucrezi ...; Porcel, Laura Mo ...; Duezel, Emrah; Grimmer, Timo; Wiltfang, Jens; Heilmann-Heimbac ...; Moebus, Susanne; Tegos, Thomas; Scarmeas, Nikola ...; Clarimon, Jordi; Moreno, Fermin; Perez-Tur, Jordi; Bullido, Maria J ...; Pastor, Pau; Sanchez-Valle, R ...; Alvarez, Victori ...; Boada, Merce; Garcia-Gonzalez, ...; Puerta, Raquel; Mir, Pablo; Real, Luis M.; Pinol-Ripoll, Ge ...; Garcia-Alberca, ...; Royo, Jose Luis; Rodriguez-Rodrig ...; Soininen, Hilkka; Kuulasmaa, Teemu; de Mendonca, Ale ...; Mehrabian, Shima; Hort, Jakub; Vyhnalek, Martin; van der Lee, Sve ...; Graff, Caroline; Papenberg, Goran; Giedraitis, Vilm ...; Boland, Anne; Bacq-Daian, Delp ...; Deleuze, Jean-Fr ...; Nicolas, Gael; Dufouil, Carole; Pasquier, Floren ...; Hanon, Olivier; Debette, Stephan ...; Gruenblatt, Edna; Popp, Julius; Benussi, Luisa; Galimberti, Dani ...; Arosio, Beatrice; Mecocci, Patrizi ...; Solfrizzi, Vince ...; Parnetti, Lucill ...; Squassina, Aless ...; Tremolizzo, Luci ...; Borroni, Barbara; Nacmias, Benedet ...; Sorbi, Sandro; Caffarra, Paolo; Seripa, Davide; Rainero, Innocen ...; Daniele, Antonio; Masullo, Carlo; Spalletta, Gianf ...; Williams, Julie; Amouyel, Philipp ...; Jessen, Frank; Kehoe, Patrick; Magda, Tsolaki; Rossi, Giacomina; Sanchez-Juan, Pa ...; Sleegers, Kriste ...; Ingelsson, Marti ...; Andreassen, Ole ...; Hiltunen, Mikko; Van Duijn, Corne ...; Sims, Rebecca; van der Flier, W ...; Ruiz, Agustin; Ramirez, Alfredo; Lambert, Jean-Ch ...; Frikke-Schmidt, ...; visa färre...

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