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- Xin, YiweiShandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China. (author)
Fusobacterium nucleatum- induced exosomal HOTTIP promotes gastric cancer progression through the microRNA-885-3p/EphB2 axis
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- 2023-03-10
- John Wiley & Sons,2023
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-511733
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-511733URI
- https://doi.org/10.1111/cas.15781DOI
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- Language:English
- Summary in:English
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- Recent studies have reported that Fusobacterium nucleatum (Fn) is associated with gastric cancer (GC). Cancer-derived exosomes contain key regulatory noncoding RNAs and are a crucial medium of intercellular communication. However, the function and regulatory mechanism of exosomes (Fn-GCEx) secreted from Fn-infected GC cells remains unclear. In this study, Fn-GCEx enhanced the proliferation, migration, and invasion capacity of GC cells in vitro, as well as tumor growth and metastasis in vivo. HOTTIP was also upregulated in GC cells treated with Fn-GCEx. Moreover, knockdown of HOTTIP weakened the effects of Fn-GCEx in recipient GC cells. Mechanistically, HOTTIP promoted EphB2 expression by sponging microRNA (miR)-885-3p, thus activating the PI3K/AKT pathway in Fn-GCEx treated GC cells. Overall, Fn infection induced the upregulation of exosomal HOTTIP from GC cells that subsequently promoted GC progression through the miR-885-3p/EphB2/PI3K/AKT axis. Herein, we identify a potential molecular pathway and therapeutic target for GC.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Exosome
- Fusobacterium nucleatum
- Gastric cancer
- HOTTIP
- lncRNA
Added entries (persons, corporate bodies, meetings, titles ...)
- Li, XinyangShandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China. (author)
- Zhang, MengjiaoShandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China. (author)
- Shang, ZiqiShandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China. (author)
- Luo, ZhengdongShandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China. (author)
- Wang, YifengShandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China. (author)
- Gui, XinruShandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China. (author)
- Liu, QiShandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China. (author)
- Li, TingtingShandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China. (author)
- Zeng, ShunjieShandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China. (author)
- Schiöth, Helgi B.Uppsala universitet,Funktionell farmakologi och neurovetenskap(Swepub:uu)helgschi (author)
- Zhang, XinShandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China. (author)
- Zhang, YiShandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China. (author)
- Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.Funktionell farmakologi och neurovetenskap (creator_code:org_t)
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- In:Cancer Science: John Wiley & Sons114:6, s. 2360-23741347-90321349-7006
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