WFRF:(Zhang Xin)
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Fusobacterium nucleatum- induced exosomal HOTTIP promotes gastric cancer progression through the microRNA-885-3p/EphB2 axis
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- Xin, Yiwei (author)
- Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.
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- Li, Xinyang (author)
- Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.
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- Zhang, Mengjiao (author)
- Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.
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- Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China. Funktionell farmakologi och neurovetenskap (creator_code:org_t)
- 2023-03-10
- 2023
- English.
- In: Cancer Science. - : John Wiley & Sons. - 1347-9032 .- 1349-7006. ; 114:6, s. 2360-2374
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Recent studies have reported that Fusobacterium nucleatum (Fn) is associated with gastric cancer (GC). Cancer-derived exosomes contain key regulatory noncoding RNAs and are a crucial medium of intercellular communication. However, the function and regulatory mechanism of exosomes (Fn-GCEx) secreted from Fn-infected GC cells remains unclear. In this study, Fn-GCEx enhanced the proliferation, migration, and invasion capacity of GC cells in vitro, as well as tumor growth and metastasis in vivo. HOTTIP was also upregulated in GC cells treated with Fn-GCEx. Moreover, knockdown of HOTTIP weakened the effects of Fn-GCEx in recipient GC cells. Mechanistically, HOTTIP promoted EphB2 expression by sponging microRNA (miR)-885-3p, thus activating the PI3K/AKT pathway in Fn-GCEx treated GC cells. Overall, Fn infection induced the upregulation of exosomal HOTTIP from GC cells that subsequently promoted GC progression through the miR-885-3p/EphB2/PI3K/AKT axis. Herein, we identify a potential molecular pathway and therapeutic target for GC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Exosome
- Fusobacterium nucleatum
- Gastric cancer
- HOTTIP
- lncRNA
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Xin, Yiwei
- Li, Xinyang
- Zhang, Mengjiao
- Shang, Ziqi
- Luo, Zhengdong
- Wang, Yifeng
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- Gui, Xinru
- Liu, Qi
- Li, Tingting
- Zeng, Shunjie
- Schiöth, Helgi B ...
- Zhang, Xin
- Zhang, Yi
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- Cancer Science
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- Uppsala University
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