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Distinct reproducti...
Distinct reproductive risk profiles for intrinsic-like breast cancer subtypes : pooled analysis of population-based studies
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- Jung, Audrey Y (författare)
- German Cancer Research Centre
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- Ahearn, Thomas U (författare)
- National Institutes of Health, United States
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- Behrens, Sabine (författare)
- German Cancer Research Centre
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visa fler...
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- Middha, Pooja (författare)
- German Cancer Research Centre
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- Bolla, Manjeet K (författare)
- University of Cambridge
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- Wang, Qin (författare)
- University of Cambridge
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- Arndt, Volker (författare)
- German Cancer Research Centre
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- Aronson, Kristan J (författare)
- Queen's University at Kingston
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- Augustinsson, Annelie (författare)
- Lund University,Lunds universitet,Karolinska Institutet,Vård i högteknologisk miljö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Cancerepidemiologi & strål,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Care in high technological environments,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Cancerepidemiology and radiation,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,University of North Carolina,Brigham and Women's Hospital / Harvard Medical School,University of Southern California,Cyprus Institute of Neurology and Genetics,University of British Columbia
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- Beane Freeman, Laura E (författare)
- National Institutes of Health, United States
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- Becher, Heiko (författare)
- University Medical Center Hamburg-Eppendorf
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- Brenner, Hermann (författare)
- German Cancer Research Centre,National Centre of Tumor Diseases
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- Canzian, Federico (författare)
- German Cancer Research Centre
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Carey, Lisa A (författare)
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- Czene, Kamila (författare)
- Karolinska Institutet,Karolinska University Hospital
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Eliassen, A Heather (författare)
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- Eriksson, Mikael (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Evans, D Gareth (författare)
- Manchester University NHS Foundation Trust
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- Figueroa, Jonine D (författare)
- National Institutes of Health, United States
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- Fritschi, Lin (författare)
- Curtin University
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- Gabrielson, Marike (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Giles, Graham G (författare)
- Cancer Council Victoria,University of Melbourne
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- Guénel, Pascal (författare)
- University of Paris-Saclay
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- Hadjisavvas, Andreas (författare)
- Cyprus Institute of Neurology and Genetics
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Haiman, Christopher A (författare)
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- Håkansson, Niclas (författare)
- Karolinska Institute,Karolinska Institutet
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- Hall, Per (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital,Stockholm South General Hospital
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- Hamann, Ute (författare)
- German Cancer Research Centre
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- Hoppe, Reiner (författare)
- University of Tübingen,Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
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- Hopper, John L (författare)
- University of Melbourne
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- Howell, Anthony (författare)
- University of Manchester
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- Hunter, David J (författare)
- Harvard T.H. Chan School of Public Health
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- Hüsing, Anika (författare)
- German Cancer Research Centre
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Kosma, Veli-Matti (författare)
- University of Eastern Finland
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- Koutros, Stella (författare)
- National Cancer Institute of Colombia
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- Kraft, Peter (författare)
- Harvard T.H. Chan School of Public Health
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- Lacey, James V (författare)
- City of Hope National Medical Center
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- Le Marchand, Loic (författare)
- University of Hawaii Cancer Center
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- Lissowska, Jolanta (författare)
- The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
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Loizidou, Maria A (författare)
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- Mannermaa, Arto (författare)
- University of Eastern Finland
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- Maurer, Tabea (författare)
- University Medical Center Hamburg-Eppendorf
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Murphy, Rachel A (författare)
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- Olshan, Andrew F (författare)
- University of North Carolina
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- Olsson, Håkan (författare)
- Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Lund Melanoma Study Group,Lund University Research Groups
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- Patel, Alpa V (författare)
- University of Pittsburgh Cancer Institute
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- Perou, Charles M (författare)
- University of North Carolina
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- Rennert, Gad (författare)
- Carmel Medical Center
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- Shibli, Rana (författare)
- Carmel Medical Center
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Shu, Xiao-Ou (författare)
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Southey, Melissa C (författare)
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Stone, Jennifer (författare)
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Tamimi, Rulla M (författare)
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Teras, Lauren R (författare)
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Troester, Melissa A (författare)
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Truong, Thérèse (författare)
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Vachon, Celine M (författare)
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Wang, Sophia S (författare)
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- Wolk, Alicja (författare)
- Uppsala universitet,Medicinsk epidemiologi,Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, 171 77, Stockholm, Sweden.
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Wu, Anna H (författare)
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Yang, Xiaohong R (författare)
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Zheng, Wei (författare)
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Dunning, Alison M (författare)
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Pharoah, Paul D P (författare)
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Easton, Douglas F (författare)
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Milne, Roger L (författare)
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Chatterjee, Nilanjan (författare)
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Schmidt, Marjanka K (författare)
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García-Closas, Montserrat (författare)
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Chang-Claude, Jenny (författare)
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(creator_code:org_t)
- 2022-06-20
- 2022
- Engelska.
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 114:12, s. 1706-1719
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Reproductive factors have been shown to be differentially associated with risk of estrogen receptor (ER) positive and ER-negative breast cancer. However, their associations with intrinsic-like subtypes are less clear.METHODS: Analyses included up to 23,353 cases, and 71,072 controls pooled from 31 population-based case-control or cohort studies in the Breast Cancer Association Consortium across 16 countries on 4 continents. Polytomous logistic regression was used to estimate the association between reproductive factors and risk of breast cancer by intrinsic-like subtypes (luminal A-like, luminal B-like, luminal B-HER2-like, HER2-enriched-like, and triple-negative) and by invasiveness. All statistical tests were 2-sided.RESULTS: Compared to nulliparous women, parous women had a lower risk of luminal A-like, luminal B-like, luminal B-HER2-like and HER2-enriched-like disease. This association was apparent only after approximately 10 years since last birth and became stronger with increasing time (odds ratio [OR] = 0.59, 95% confidence interval [CI] = 0.49 to 0.71; and OR = 0.36, 95% CI = 0.28 to 0.46; for multiparous women with luminal A-like tumors 20-<25 years after last birth and 45-<50 years after last birth, respectively). In contrast, parous women had a higher risk of triple-negative breast cancer right after their last birth (for multiparous women: OR = 3.12, 95%CI = 2.02 to 4.83) that was attenuated with time but persisted for decades (OR = 1.03, 95%CI = 0.79 to 1.34, for multiparous women 25 to < 30 years after last birth). Older age at first birth (P-heterogeneity<.001 for triple-negative compared to luminal-A like) and breastfeeding (P-heterogeneity<.001 for triple-negative compared to luminal-A like) were associated with lower risk of triple-negative but not with other disease subtypes. Younger age at menarche was associated with higher risk of all subtypes; older age at menopause was associated with higher risk of luminal A-like but not triple-negative breast cancer. Associations for in situ tumors were similar to luminal A-like.CONCLUSION: This large and comprehensive study demonstrates a distinct reproductive risk factor profile for triple-negative breast cancer compared to other subtypes, with implications for the understanding of disease etiology and risk prediction.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- breast cancer
- intrinsic-like subtypes
- reproductive risk factors
- triple-negative
- Female
- Humans
- Breast Neoplasms/etiology
- Receptor, ErbB-2
- Receptors, Progesterone
- Receptors, Estrogen
- Triple Negative Breast Neoplasms/epidemiology
- Case-Control Studies
- Risk Factors
- Biomarkers, Tumor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Jung, Audrey Y
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Ahearn, Thomas U
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Behrens, Sabine
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Middha, Pooja
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Bolla, Manjeet K
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Wang, Qin
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visa fler...
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Arndt, Volker
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Aronson, Kristan ...
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Augustinsson, An ...
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Beane Freeman, L ...
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Becher, Heiko
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Brenner, Hermann
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Canzian, Federic ...
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Carey, Lisa A
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Czene, Kamila
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Eliassen, A Heat ...
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Eriksson, Mikael
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Evans, D Gareth
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Figueroa, Jonine ...
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Fritschi, Lin
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Gabrielson, Mari ...
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Giles, Graham G
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Guénel, Pascal
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Hadjisavvas, And ...
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Haiman, Christop ...
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Håkansson, Nicla ...
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Hall, Per
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Hamann, Ute
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Hoppe, Reiner
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Hopper, John L
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Howell, Anthony
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Hunter, David J
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Hüsing, Anika
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Kaaks, Rudolf
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Kosma, Veli-Matt ...
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Koutros, Stella
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Kraft, Peter
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Lacey, James V
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Le Marchand, Loi ...
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Lissowska, Jolan ...
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Loizidou, Maria ...
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Mannermaa, Arto
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Maurer, Tabea
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Murphy, Rachel A
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Olshan, Andrew F
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Olsson, Håkan
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Patel, Alpa V
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Perou, Charles M
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Rennert, Gad
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Shibli, Rana
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Shu, Xiao-Ou
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Southey, Melissa ...
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Stone, Jennifer
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Tamimi, Rulla M
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Teras, Lauren R
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Troester, Meliss ...
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Truong, Thérèse
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Vachon, Celine M
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Wang, Sophia S
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Wolk, Alicja
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Wu, Anna H
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Yang, Xiaohong R
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Zheng, Wei
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Dunning, Alison ...
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Pharoah, Paul D ...
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Easton, Douglas ...
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Milne, Roger L
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Chatterjee, Nila ...
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Schmidt, Marjank ...
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García-Closas, M ...
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Chang-Claude, Je ...
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Journal of the N ...
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Uppsala universitet
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Karolinska Institutet
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Lunds universitet