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A genome-wide gene-...
A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry
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- Middha, Pooja K. (author)
- German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.,German Cancer Research Centre
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- Wang, Xiaoliang (author)
- Univ Washington, Dept Epidemiol, Sch Publ Hlth, Seattle, WA USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA USA.,University of Washington
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- Behrens, Sabine (author)
- German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.,German Cancer Research Centre
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show more...
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- Bolla, Manjeet K. (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.,University of Cambridge
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- Wang, Qin (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.,University of Cambridge
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- Dennis, Joe (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.,University of Cambridge
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- Michailidou, Kyriaki (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.;Cyprus Inst Neurol & Genet, Biostat Unit, Nicosia, Cyprus.,University of Cambridge
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- Ahearn, Thomas U. (author)
- NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD USA.,National Institutes of Health, United States
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- Andrulis, Irene L. (author)
- Lunenfeld Tanenbaum Res Inst Mt Sinai Hosp, Fred Litwin Ctr Canc Genet, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.,University of Toronto
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- Anton-Culver, Hoda (author)
- Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Med, Irvine, CA USA.
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- Arndt, Volker (author)
- German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
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- Aronson, Kristan J. (author)
- Queens Univ & Canc Res Inst, Dept Publ Hlth Sci, Kingston, ON, Canada.
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- Auer, Paul L. (author)
- Med Coll Wisconsin & Canc Ctr, Inst Hlth & Equity, Div Biostat, Milwaukee, WI USA.
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- Augustinsson, Annelie (author)
- Lund University,Lunds universitet,Vård i högteknologisk miljö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Care in high technological environments,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Baert, Thais (author)
- Univ Hosp Leuven, Leuven Canc Inst, Dept Oncol, Leuven Multidisciplinary Breast Ctr, Leuven, Belgium.
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- Freeman, Laura E. Beane (author)
- NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD USA.
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- Becher, Heiko (author)
- Univ Med Ctr Hamburg Eppendorf, Inst Med Biometry & Epidemiol, Hamburg, Germany.
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- Beckmann, Matthias W. (author)
- Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Gynecol & Obstet, Comprehens Canc Ctr Erlangen EMN, Erlangen, Germany.
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- Benitez, Javier (author)
- Spanish Natl Canc Res Ctr CNIO, Human Genet Grp, Madrid, Spain.;Inst Salud Carlos III, Ctr Biomed Network Res Rare Dis CIBERER, Madrid, Spain.
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- Bojesen, Stig E. (author)
- Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark.
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- Brauch, Hiltrud (author)
- Dr Margarete Fischer Bosch Inst Clin Pharmac, Stuttgart, Germany.;Univ Tubingen, IFIT Cluster Excellence, Tubingen, Germany.;Univ Tubingen, IFIT Cluster Excellence, Tubingen, Germany.
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- Brenner, Hermann (author)
- German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;German Canc Consortium DKTK, Partner Site Tubingen, Tubingen, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany.
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- Brooks-Wilson, Angela (author)
- Canadas Michael Smith Genome Sci Ctr, Vancouver, BC, Canada.
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- Campa, Daniele (author)
- German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Univ Pisa, Dept Biol, Pisa, Italy.
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- Canzian, Federico (author)
- German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany.
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- Carracedo, Angel (author)
- Complejo Hosp Univ Santiago, Inst Investig Sanitaria Santiago DeCompostela IDI, Genom Med Grp, Int Canc Genet & Epidemiol Grp, Santiago De Compostela, Spain.;Univ Santiago De Compostela, Ctr Investigac Red Enfermedades Raras CIBERER, Grp Med Xenom, Santiago De Compostela, Spain.
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- Castelao, Jose E. (author)
- Xerencia Xest Integrada Vigo SERGAS, Inst Invest Sanitaria Galicia IISGS, Oncol & Genet Unit, Vigo, Spain.
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- Chanock, Stephen J. (author)
- NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD USA.
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- Chenevix-Trench, Georgia (author)
- QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia.
-
- Cordina-Duverger, Emilie (author)
- Univ Paris Saclay, Team Exposome & Hered, CESP, Villejuif, France.
-
- Couch, Fergus J. (author)
- Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.
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- Cox, Angela (author)
- Univ Sheffield, Sheffield Inst Nucle Acids SInFoNiA, Dept Oncol & Metab, Sheffield, S Yorkshire, England.
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- Cross, Simon S. (author)
- Univ Sheffield, Acad Unit Pathol, Dept Neurosci, Sheffield, S Yorkshire, England.
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- Czene, Kamila (author)
- Karolinska Institutet
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- Dossus, Laure (author)
- Int Agcy Res Canc IARC WHO, Nutr & Metab Sect, Lyon, France.
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- Dugue, Pierre-Antoine (author)
- Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.;Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.
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- Eliassen, A. Heather (author)
- Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
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- Eriksson, Mikael (author)
- Karolinska Institutet
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- Evans, D. Gareth (author)
- Univ Manchester, Manchester Acad Hlth Sci Ctr, Sch Biol Sci, Div Evolut & Genom Sci, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, St Marys Hosp, Manchester Ctr Genom Med, Manchester, Lancs, England.
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- Fasching, Peter A. (author)
- Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Gynecol & Obstet, Comprehens Canc Ctr Erlangen EMN, Erlangen, Germany.
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- Figueroa, Jonine (author)
- NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD USA.;Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Canc Res UK Edinburgh Ctr, Edinburgh, Midlothian, Scotland.
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- Fletcher, Olivia (author)
- Breast Canc Now Toby Robins Res Ctr, Inst Canc Res, London, England.
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- Flyger, Henrik (author)
- Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Breast Surg, Herlev, Denmark.
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- Gabrielson, Marike (author)
- Karolinska Institutet
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- Gago-Dominguez, Manuela (author)
- Complejo Hosp Univ Santiago, Inst Investig Sanitaria Santiago DeCompostela IDI, Genom Med Grp, Int Canc Genet & Epidemiol Grp, Santiago De Compostela, Spain.
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- Giles, Graham G. (author)
- Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.;Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.
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- Gonzalez-Neira, Anna (author)
- Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Madrid, Spain.
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- Grassmann, Felix (author)
- Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Hlth & Med Univ, Inst Clin Res & Syst Med, Potsdam, Germany.
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- Grundy, Anne (author)
- Queens Univ, Dept Publ Hlth Sci, Kingston, ON, Canada.
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- Guenel, Pascal (author)
- Univ Paris Saclay, Team Exposome & Hered, CESP, Villejuif, France.
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- Haiman, Christopher A. (author)
- Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA.
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- Hakansson, Niclas (author)
- Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
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- Hall, Per (author)
- Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Soder Sjukhuset, Dept Oncol, Stockholm, Sweden.
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- Hamann, Ute (author)
- German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany.
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- Hankinson, Susan E. (author)
- Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA.;Univ Massachusetts, Dept Biostat & Epidemiol, Amherst, MA USA.
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- Harkness, Elaine F. (author)
- Univ Manchester, Manchester Acad Hlth Sci Ctr, Div Informat Imaging & Data Sci, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Wythenshawe Hosp, Nightingale & Genesis Prevent Ctr, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, NIHR Manchester Biomed Res Unit, Manchester, Lancs, England.
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- Holleczek, Bernd (author)
- Saarland Canc Registry, Saarbrucken, Germany.
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- Hoppe, Reiner (author)
- Dr Margarete Fischer Bosch Inst Clin Pharmac, Stuttgart, Germany.;Inst Canc Res, Div Genet & Epidemiol, London, England.
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- Hopper, John L. (author)
- Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.
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- Houlston, Richard S. (author)
- Univ Manchester, Div Canc Sci, Manchester, Lancs, England.
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- Howell, Anthony (author)
- Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.
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- Hunter, David J. (author)
- Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Lund Univ, Clin Sci Lund, Surg, Lund, Sweden.
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- Ingvar, Christian (author)
- Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund Melanoma Study Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Isaksson, Karolin (author)
- Stanford Univ, Dept Epidemiol & Populat Hlth, Sch Med, Stanford, CA USA.,Central Hospital Kristianstad
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- Jernström, Helena (author)
- Lund University,Lunds universitet,Epidemiologi och farmakogenetik,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Epidemiology and pharmacogenetics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- John, Esther M. (author)
- Stanford Univ, Stanford Canc Inst, Div Oncol, Dept Med,Sch Med, Stanford, CA USA.;Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands.
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- Jones, Michael E. (author)
- Univ Manchester, Div Canc Sci, Manchester, Lancs, England.
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- Kaaks, Rudolf (author)
- German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
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- Keeman, Renske (author)
- NCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD USA.
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- Kitahara, Cari M. (author)
- Johanniter GmbH Bonn, Dept Internal Med, Johanniter Krankenhaus, Bonn, Germany.
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- Ko, Yon-Dschun (author)
- Katholieke Univ Leuven, Dept Human Genet, Lab Translat Genet, Leuven, Belgium.
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Koutros, Stella (author)
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- Kurian, Allison W. (author)
- Stanford Univ, Stanford Canc Inst, Div Oncol, Dept Med,Sch Med, Stanford, CA USA.;Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands.
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- Lacey, James V. (author)
- City Hope Natl Med Ctr, Dept Computat & Quantitat Med, Duarte, CA USA.;City Hope Natl Med Ctr, City Hope Comprehens Canc Ctr, Duarte, CA USA.
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- Lambrechts, Diether (author)
- VIB, VIB Ctr Canc Biol, Leuven, Belgium.;Mayo Clin, Div Epidemiol, Dept Quantitat Hlth Sci, Rochester, MN USA.
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- Larson, Nicole L. (author)
- Uppsala Univ, Dept Surg Sci, Uppsala, Sweden.
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- Larsson, Susanna C. (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för kirurgiska vetenskaper,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Univ Hawaii Canc Ctr, Program Epidemiol, Honolulu, HI USA.
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- Le Marchand, Loic (author)
- Clalit Natl Canc Control Ctr, Carmel Med Ctr & Techn Fac Med, Haifa, Israel.
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- Lejbkowicz, Flavio (author)
- M Sklodowska Curie Natl Res Oncol Inst, Dept Canc Epidemiol & Prevent, Warsaw, Poland.
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- Li, Shuai (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.
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- Linet, Martha (author)
- Johanniter GmbH Bonn, Dept Internal Med, Johanniter Krankenhaus, Bonn, Germany.
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- Lissowska, Jolanta (author)
- Univ Calif San Diego, Moores Canc Ctr, Herbert Wertheim Sch Publ Hlth, San Diego, CA USA.
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- Martinez, Maria Elena (author)
- Univ Canc Ctr Hamburg UCCH, Univ Med Ctr Hamburg Eppendorf, Canc Epidemiol Grp, Hamburg, Germany.
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- Maurer, Tabea (author)
- Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
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- Mulligan, Anna Marie (author)
- Univ Hlth Network, Lab Med Program, Toronto, ON, Canada.;Univ Paris Cite, INSERM UMR S1138, CRB EPIGENETEC, Paris, France.
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- Mulot, Claire (author)
- Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada.;Canc Control Res, Vancouver, BC, Canada.
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- Murphy, Rachel A. (author)
- Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Res Triangle Pk, NC USA.;Amer Canc Soc, Dept Populat Sci, Atlanta, GA USA.
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- Newman, William G. (author)
- Univ Manchester, Manchester Acad Hlth Sci Ctr, Sch Biol Sci, Div Evolut & Genom Sci, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, St Marys Hosp, Manchester Ctr Genom Med, Manchester, Lancs, England.
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- Nielsen, Sune F. (author)
- Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark.
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- Nordestgaard, Borge G. (author)
- Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark.
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- Norman, Aaron (author)
- Uppsala Univ, Dept Surg Sci, Uppsala, Sweden.
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- O'Brien, Katie M. (author)
- Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA USA.
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Olson, Janet E. (author)
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- Patel, Alpa V. (author)
- Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England.
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- Prentice, Ross (author)
- Mayo Clin, Dept Oncol, Rochester, MN USA.
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- Rees-Punia, Erika (author)
- Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England.
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- Rennert, Gad (author)
- M Sklodowska Curie Natl Res Oncol Inst, Dept Canc Epidemiol & Prevent, Warsaw, Poland.
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- Rhenius, Valerie (author)
- Mayo Clin, Div Clin Trials & Biostat, Dept Quantitat Hlth Sci, Rochester, MN USA.
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- Ruddy, Kathryn J. (author)
- Vanderbilt Univ, Div Epidemiol, Dept Med, Vanderbilt Epidemiol Ctr,Sch Med, Nashville, TN USA.
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- Sandler, Dale P. (author)
- Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA USA.
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- Scott, Christopher G. (author)
- Univ Hosp Leuven, Dept Surg Oncol, Leuven, Belgium.
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- Shah, Mitul T. (author)
- Mayo Clin, Div Clin Trials & Biostat, Dept Quantitat Hlth Sci, Rochester, MN USA.
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- Shu, Xiao-Ou (author)
- Univ Melbourne, Dept Clin Pathol, Melbourne, Vic, Australia.
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- Smeets, Ann (author)
- Univ Western Australia, Sch Populat & Global Hlth, Genet Epidemiol Grp, Perth, WA, Australia.
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- Southey, Melissa C. (author)
- Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.;Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Weill Cornell Med, Dept Populat Hlth Sci, New York, NY USA.
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- Stone, Jennifer (author)
- Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.;Natl Inst Environm Hlth Sci, Epigenet & Stem Cell Biol Lab, NIH, Res Triangle Pk, NC USA.
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- Tamimi, Rulla M. (author)
- Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA.
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- Taylor, Jack A. (author)
- Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA USA.;Univ N Carolina, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA.
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- Teras, Lauren R. (author)
- Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England.
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- Tomczyk, Katarzyna (author)
- Breast Canc Now Toby Robins Res Ctr, Inst Canc Res, London, England.
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- Troester, Melissa A. (author)
- Natl Inst Environm Hlth Sci, Biostat & Computat Biol Branch, NIH, Res Triangle Pk, NC USA.
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- Truong, Therese (author)
- Univ Paris Saclay, Team Exposome & Hered, CESP, Villejuif, France.
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- Vachon, Celine M. (author)
- Uppsala Univ, Dept Surg Sci, Uppsala, Sweden.
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- Wang, Sophia S. (author)
- City Hope Natl Med Ctr, Dept Computat & Quantitat Med, Duarte, CA USA.;City Hope Natl Med Ctr, City Hope Comprehens Canc Ctr, Duarte, CA USA.
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- Weinberg, Clarice R. (author)
- Mayo Clin, Div Computat Biol, Dept Quantitat Hlth Sci, Rochester, MN USA.
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- Wildiers, Hans (author)
- Univ Hosp Leuven, Leuven Canc Inst, Dept Oncol, Leuven Multidisciplinary Breast Ctr, Leuven, Belgium.
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- Willett, Walter (author)
- Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
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- Winham, Stacey J. (author)
- Hosp Univ La Paz, Serv Oncol Med, Madrid, Spain.
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- Wolk, Alicja (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Univ Hawaii Canc Ctr, Program Epidemiol, Honolulu, HI USA.
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Yang, Xiaohong (author)
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- Zamora, M. Pilar (author)
- Netherlands Canc Inst Antoni Leeuwenhoek Hosp, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands.
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- Zheng, Wei (author)
- Univ Melbourne, Dept Clin Pathol, Melbourne, Vic, Australia.
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- Ziogas, Argyrios (author)
- Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Med, Irvine, CA USA.
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- Dunning, Alison M. (author)
- Mayo Clin, Div Clin Trials & Biostat, Dept Quantitat Hlth Sci, Rochester, MN USA.
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- Pharoah, Paul D. P. (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.;Mayo Clin, Div Clin Trials & Biostat, Dept Quantitat Hlth Sci, Rochester, MN USA.
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- Garcia-Closas, Montserrat (author)
- NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD USA.
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- Schmidt, Marjanka K. (author)
- NCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD USA.;Harvard TH Chan Publ Hlth, Program Genet Epidemiol & Stat Genet, Sch Publ Hlth, Boston, MA USA.
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- Kraft, Peter (author)
- Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
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- Milne, Roger L. (author)
- Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.;Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.
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- Lindstroem, Sara (author)
- Univ Washington, Dept Epidemiol, Sch Publ Hlth, Seattle, WA USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA USA.
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- Easton, Douglas F. (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.;Mayo Clin, Div Clin Trials & Biostat, Dept Quantitat Hlth Sci, Rochester, MN USA.
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- Chang-Claude, Jenny (author)
- German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
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German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany German Cancer Research Centre (creator_code:org_t)
- BioMed Central (BMC), 2023
- 2023
- English.
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In: Breast Cancer Research. - : BioMed Central (BMC). - 1465-5411 .- 1465-542X. ; 25:1
- Related links:
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Abstract
Subject headings
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- Background Genome-wide studies of gene-environment interactions (GxE) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide GxE analysis of similar to 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer. Methods Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs. Results Assuming a 1 x 10(-5) prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability < 15%, we identified two independent SNP-risk factor pairs: rs80018847(9p13)-LINGO2 and adult height in association with overall breast cancer risk (ORint = 0.94, 95% CI 0.92-0.96), and rs4770552(13q12)-SPATA13 and age at menarche for ER + breast cancer risk (ORint = 0.91, 95% CI 0.88-0.94). Conclusions Overall, the contribution of GxE interactions to the heritability of breast cancer is very small. At the population level, multiplicative GxE interactions do not make an important contribution to risk prediction in breast cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Breast cancer
- Gene-environment interactions
- Genetic epidemiology
- European ancestry
- Adult
- Female
- Humans
- Gene-Environment Interaction
- Genetic Predisposition to Disease
- Breast Neoplasms/etiology
- Bayes Theorem
- Genome-Wide Association Study
- Risk Factors
- Polymorphism, Single Nucleotide
- Case-Control Studies
Publication and Content Type
- ref (subject category)
- art (subject category)
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Middha, Pooja K.
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Wang, Xiaoliang
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Grundy, Anne
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Guenel, Pascal
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Haiman, Christop ...
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Hakansson, Nicla ...
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Hall, Per
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Hamann, Ute
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Hankinson, Susan ...
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Harkness, Elaine ...
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Holleczek, Bernd
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Hoppe, Reiner
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Hopper, John L.
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Houlston, Richar ...
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Howell, Anthony
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Hunter, David J.
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Ingvar, Christia ...
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Isaksson, Karoli ...
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Jernström, Helen ...
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John, Esther M.
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Jones, Michael E ...
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Kaaks, Rudolf
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Keeman, Renske
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Kitahara, Cari M ...
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Ko, Yon-Dschun
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Koutros, Stella
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Kurian, Allison ...
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Lacey, James V.
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Lambrechts, Diet ...
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Larson, Nicole L ...
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Larsson, Susanna ...
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Le Marchand, Loi ...
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Lejbkowicz, Flav ...
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Li, Shuai
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Linet, Martha
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Lissowska, Jolan ...
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Martinez, Maria ...
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Maurer, Tabea
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Mulligan, Anna M ...
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Mulot, Claire
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Murphy, Rachel A ...
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Newman, William ...
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Nielsen, Sune F.
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Nordestgaard, Bo ...
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Norman, Aaron
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O'Brien, Katie M ...
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Olson, Janet E.
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Patel, Alpa V.
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Prentice, Ross
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Rees-Punia, Erik ...
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Rennert, Gad
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Rhenius, Valerie
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Ruddy, Kathryn J ...
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Sandler, Dale P.
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Scott, Christoph ...
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Shah, Mitul T.
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Shu, Xiao-Ou
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Smeets, Ann
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Southey, Melissa ...
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Stone, Jennifer
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Tamimi, Rulla M.
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Taylor, Jack A.
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Teras, Lauren R.
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Tomczyk, Katarzy ...
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Troester, Meliss ...
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Truong, Therese
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Vachon, Celine M ...
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Wang, Sophia S.
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Weinberg, Claric ...
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Wildiers, Hans
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Willett, Walter
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Winham, Stacey J ...
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Wolk, Alicja
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Yang, Xiaohong
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Zamora, M. Pilar
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Zheng, Wei
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Dunning, Alison ...
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Pharoah, Paul D. ...
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Garcia-Closas, M ...
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Schmidt, Marjank ...
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Kraft, Peter
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Milne, Roger L.
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Easton, Douglas ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Breast Cancer Re ...
- By the university
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Uppsala University
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Karolinska Institutet
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Lund University