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Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways : Challenges and Opportunities

Audouze, Karine (author)
Univ Paris, T3S, Inserm U1124, Paris, France.,Université de Paris, T3S, Inserm U1124, Paris, France
Zgheib, Elias (author)
Univ Paris, T3S, Inserm U1124, Paris, France.,Université de Paris, T3S, Inserm U1124, Paris, France
Abass, Khaled (author)
Univ Oulu, Univ Arctic, Thule Inst, Oulu, Finland.;Menoufia Univ, Dept Pesticides, Menoufia, Egypt.,Thule Institute, University of Arctic, University of Oulu, Oulu, Finland; Department of Pesticides, Menoufia University, Menoufia, Egypt
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Baig, Asma H. (author)
Brunel Univ London, Ctr Pollut Res & Policy, Uxbridge, England.,Centre for Pollution Research and Policy, Brunel University London, Uxbridge, United Kingdom,Department of Biology, University of Southern Denmark, Odense, Denmark,Univ Southern Denmark, Dept Biol, Odense, Denmark.
Forner-Piquer, Isabel (author)
Brunel Univ London, Ctr Pollut Res & Policy, Uxbridge, England.,Centre for Pollution Research and Policy, Brunel University London, Uxbridge, United Kingdom
Holbech, Henrik (author)
Univ Southern Denmark, Dept Biol, Odense, Denmark.
Knapen, Dries (author)
Univ Antwerp, Dept Vet Sci, Zebrafishlab, Antwerp, Belgium.,Zebrafishlab, Department of Veterinary Sciences, University of Antwerp, Wilrijk, Belgium
Leonards, Pim E. G. (author)
Vrije Univ Amsterdam, Dept Environm & Hlth, Amsterdam, Netherlands.,Department of Environment and Health, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
Lupu, Diana I. (author)
Uppsala universitet,Fysiologi och miljötoxikologi,Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
Palaniswamy, Saranya (author)
Univ Oulu, Fac Med, Ctr Life Course Hlth Res, Oulu, Finland.,Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
Rautio, Arja (author)
Univ Oulu, Univ Arctic, Thule Inst, Oulu, Finland.,Thule Institute, University of Arctic, University of Oulu, Oulu, Finland
Sapounidou, Maria (author)
Umeå universitet,Kemiska institutionen,Umeå Univ, Fac Sci & Technol, Dept Chem, Umeå, Sweden.
Martin, Olwenn V. (author)
Brunel Univ London, Ctr Pollut Res & Policy, Uxbridge, England.,Centre for Pollution Research and Policy, Brunel University London, Uxbridge, United Kingdom
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Univ Paris, T3S, Inserm U1124, Paris, France Université de Paris, T3S, Inserm U1124, Paris, France (creator_code:org_t)
2021-12-21
2021
English.
In: Frontiers in Toxicology. - : Frontiers Media S.A.. - 2673-3080. ; 3
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • A transformation of regulatory toxicology is underway to meet the demands of testing increasing numbers of chemicals whilst reducing reliance on in vivo models. This transformation requires a shift from chemical safety assessment largely based on direct empirical observation of apical toxicity outcomes in whole organisms to predictive approaches in which outcomes and risks are inferred from accumulated mechanistic understanding. 

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Keyword

adverse outcome pathways
endocrine disruption
systematic (literature) review
machine learning
evidence-based methods

Publication and Content Type

ref (subject category)
art (subject category)

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