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Regulatory B cells ...
Regulatory B cells producing IL-10 are increased in human tumor draining lymph nodes
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- Piersiala, Krzysztof (författare)
- Karolinska Institutet
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- Hjalmarsson, Eric (författare)
- Karolinska Institutet
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- da Silva, Pedro Farrajota Neves (författare)
- Karolinska Institutet
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- Lagebro, Vilma (författare)
- Karolinska Institutet
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- Kolev, Aeneas (författare)
- Karolinska Institutet
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- Starkhammar, Magnus (författare)
- Karolinska Inst, Dept Clin Sci Intervent & Technol, Div ENT Dis, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Otorhinolaryngol, Stockholm, Sweden.
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- Elliot, Alexandra (författare)
- Karolinska Institutet
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- Marklund, Linda (författare)
- Karolinska Institutet,Uppsala universitet,Öron-, näs- och halssjukdomar,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div ENT Dis, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Otorhinolaryngol, Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Head Neck Lung & Skin Canc, Stockholm, Sweden.
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- Munck-Wikland, Eva (författare)
- Karolinska Inst, Dept Clin Sci Intervent & Technol, Div ENT Dis, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Otorhinolaryngol, Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Head Neck Lung & Skin Canc, Stockholm, Sweden.
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- Margolin, Gregori (författare)
- Karolinska Inst, Dept Clin Sci Intervent & Technol, Div ENT Dis, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Otorhinolaryngol, Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Head Neck Lung & Skin Canc, Stockholm, Sweden.
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- Georen, Susanna Kumlien (författare)
- Karolinska Institutet
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- Cardell, Lars-Olaf (författare)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Dept Clin Sci Intervent & Technol, Div ENT Dis, Stockholm, Sweden;Karolinska Univ Hosp, Dept Otorhinolaryngol, Stockholm, Sweden. (creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- Engelska.
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 153:4, s. 854-866
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The contribution of different immune cell subsets, especially T cells, in anti-tumor immune response is well established. In contrast to T cells, the anti-tumor contribution of B cells has been scarcely investigated. B-cells are often overlooked, even though they are important players in a fully integrated immune response and constitute a substantial fraction of tumor draining lymph nodes (TDLNs) known also as Sentinel Nodes. In this project, samples including TDLNs, non-TDLNs (nTDLNs) and metastatic lymph nodes from 21 patients with oral squamous cell carcinoma were analyzed by flow cytometry. TDLNs were characterized by a significantly higher proportion of B cells compared with nTDLNs (P = .0127). TDLNs-associated B cells contained high percentages of naive B cells, in contrary to nTDLNs which contained significantly higher percentages of memory B cells. Patients having metastases in TDLNs showed a significantly higher presence of immunosuppressive B regulatory cells compared with metastasis-free patients (P = .0008). Elevated levels of regulatory B cells in TDLNs were associated with the advancement of the disease. B cells in TDLNs were characterized by significantly higher expression of an immunosuppressive cytokine-IL-10 compared with nTDLNs (P = .0077). Our data indicate that B cells in human TDLNs differ from B cells in nTDLNs and exhibit more naive and immunosuppressive phenotypes. We identified a high accumulation of regulatory B cells within TDLNs which may be a potential obstacle in achieving response to novel cancer immunotherapies (ICIs) in head and neck cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- B regulatory cells
- oral cancer
- tumor-draining lymph nodes
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Piersiala, Krzys ...
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Hjalmarsson, Eri ...
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da Silva, Pedro ...
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Lagebro, Vilma
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Kolev, Aeneas
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Starkhammar, Mag ...
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Elliot, Alexandr ...
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Marklund, Linda
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Munck-Wikland, E ...
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Margolin, Gregor ...
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Georen, Susanna ...
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Cardell, Lars-Ol ...
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