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Effects of Dapaglif...
Effects of Dapagliflozin in Heart Failure with Reduced Ejection Fraction and Chronic Obstructive Pulmonary Disease : An Analysis of DAPA-HF.
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Dewan, Pooja (författare)
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Docherty, Kieran F. (författare)
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Bengtsson, Olof (författare)
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de Boer, Rudolf A. (författare)
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Desai, Akshay S. (författare)
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Drozdz, Jaroslaw (författare)
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Hawkins, Nathaniel M. (författare)
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Inzucchi, Silvio E. (författare)
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Kitakaze, Masafumi (författare)
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Kober, Lars (författare)
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Kosiborod, Mikail N. (författare)
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Langkilde, Anna Maria (författare)
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Lindholm, Daniel (författare)
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Martinez, Felipe A. (författare)
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Merkely, Bela (författare)
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Petrie, Mark C. (författare)
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Ponikowski, Piotr (författare)
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Sabatine, Marc S. (författare)
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Schou, Morten (författare)
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Sjostrand, Mikaela (författare)
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Solomon, Scott D. (författare)
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Verma, Subodh (författare)
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Jhund, Pardeep S. (författare)
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McMurray, John J. V. (författare)
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- 2021-01-18
- 2021
- Engelska.
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Ingår i: European journal of heart failure. - : Wiley. - 1388-9842 .- 1879-0844. ; 23:4, s. 632-643
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- AIMS: Chronic obstructive pulmonary disease (COPD) is an important comorbidity in heart failure (HF) with reduced ejection fraction (HFrEF), associated with worse outcomes and often suboptimal treatment because of under-prescription of beta-blockers. Consequently, additional effective therapies are especially relevant in patients with COPD. The aim of this study was to examine outcomes related to COPD in a post hoc analysis of the Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure (DAPA-HF) trial. METHODS AND RESULTS: We examined whether the effects of dapagliflozin in DAPA-HF were modified by COPD status. The primary outcome was the composite of an episode of worsening HF or cardiovascular death. Overall, 585 (12.3%) of the 4744 patients randomized had a history of COPD. Patients with COPD were more likely to be older men with a history of smoking, worse renal function, and higher baseline N-terminal pro B-type natriuretic peptide, and less likely to be treated with a beta-blocker or mineralocorticoid receptor antagonist. The incidence of the primary outcome was higher in patients with COPD than in those without [18.9 (95% confidence interval 16.0-22.2) vs. 13.0 (12.1-14.0) per 100 person-years; hazard ratio (HR) for COPD vs. no COPD 1.44 (1.21-1.72); P $<$ 0.001]. The effect of dapagliflozin, compared with placebo, on the primary outcome, was consistent in patients with [HR 0.67 (95% confidence interval 0.48-0.93)] and without COPD [0.76 (0.65-0.87); interaction P-value 0.47]. CONCLUSIONS: In DAPA-HF, one in eight patients with HFrEF had concomitant COPD. Participants with COPD had a higher risk of the primary outcome. The benefit of dapagliflozin on all pre-specified outcomes was consistent in patients with and without COPD. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov ID NCT03036124.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- *Heart Failure/complications/drug therapy/epidemiology
- *Pulmonary Disease
- Chronic Obstructive/complications/drug therapy/epidemiology
- Aged
- Benzhydryl Compounds
- Chronic obstructive pulmonary disease
- Dapagliflozin
- Glucosides/therapeutic use
- Heart failure
- Humans
- Male
- Stroke Volume
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Dewan, Pooja
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Docherty, Kieran ...
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Bengtsson, Olof
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de Boer, Rudolf ...
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Desai, Akshay S.
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Drozdz, Jaroslaw
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visa fler...
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Hawkins, Nathani ...
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Inzucchi, Silvio ...
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Kitakaze, Masafu ...
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Kober, Lars
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Kosiborod, Mikai ...
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Langkilde, Anna ...
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Lindholm, Daniel
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Martinez, Felipe ...
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Merkely, Bela
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Petrie, Mark C.
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Ponikowski, Piot ...
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Sabatine, Marc S ...
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Schou, Morten
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Sjostrand, Mikae ...
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Solomon, Scott D ...
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Verma, Subodh
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Jhund, Pardeep S ...
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McMurray, John J ...
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