SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Giorgakis E)
 

Sökning: WFRF:(Giorgakis E) > (2023) > Outcomes after live...

Outcomes after liver transplantation using deceased after circulatory death donors : A comparison of outcomes in the UK and the US

Ivanics, Tommy (författare)
Uppsala universitet,Gastrointestinalkirurgi,Univ Toronto, Univ Hlth Network, Multiorgan Transplant Program, Toronto, ON, Canada.;Henry Ford Hosp, Dept Surg, Detroit, MI USA.
Claasen, Marco P. A. W. (författare)
Univ Toronto, Univ Hlth Network, Multiorgan Transplant Program, Toronto, ON, Canada.;Univ Med Ctr Rotterdam, Erasmus MC Transplant Inst, Dept Surg, Div HPB & Transplant Surg, Rotterdam, Netherlands.
Patel, Madhukar S. S. (författare)
Univ Texas Southwestern Med Ctr, Div Surg Transplantat, Dept Surg, Dallas, TX USA.
visa fler...
Giorgakis, Emmanouil (författare)
Univ Arkansas Med Sci, Dept Surg, Div Transplantat, Little Rock, AR USA.;Univ Arkansas Med Sci, Rockefeller Canc Ctr Inst, Dept Surg Oncol, Hepatopancreatobiliary Surg, Little Rock, AR USA.;Kings Coll Hosp NHS Fdn Trust, Inst Liver Studies, London, England.
Khorsandi, Shirin E. E. (författare)
Kings Coll Hosp NHS Fdn Trust, Inst Liver Studies, London, England.;Fdn Liver Res, Roger Williams Inst Hepatol, London, England.;Kings Coll London, Fac Life Sci & Med, London, England.
Srinivasan, Parthi (författare)
Kings Coll Hosp NHS Fdn Trust, Inst Liver Studies, London, England.
Prachalias, Andreas (författare)
Kings Coll Hosp NHS Fdn Trust, Inst Liver Studies, London, England.
Menon, Krishna (författare)
Kings Coll Hosp NHS Fdn Trust, Inst Liver Studies, London, England.
Jassem, Wayel (författare)
Kings Coll Hosp NHS Fdn Trust, Inst Liver Studies, London, England.
Cortes, Miriam (författare)
Kings Coll Hosp NHS Fdn Trust, Inst Liver Studies, London, England.
Sayed, Blayne A. A. (författare)
Mathur, Amit K. K. (författare)
Mayo Clin, Dept Surg, Div Transplantat, Phoenix, AZ USA.
Walker, Kate (författare)
London Sch Hyg & Trop Med, Dept Hlth Serv Res & Policy, London, England.
Taylor, Rhiannon (författare)
London Sch Hyg & Trop Med, Dept Hlth Serv Res & Policy, London, England.;Natl Hlth Serv Blood & Transplant, Dept Stat, Bristol, England.
Heaton, Nigel (författare)
Kings Coll Hosp NHS Fdn Trust, Inst Liver Studies, London, England.
Mehta, Neil (författare)
Univ Calif San Francisco, Dept Med, Div Gastroenterol, San Francisco, CA USA.
Segev, Dorry L. L. (författare)
Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.;Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD USA.;NYU Grossman Sch Med, Dept Surg, New York, NY USA.;NYU Langone Hlth, New York, NY USA.
Massie, Allan B. B. (författare)
Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.;Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD USA.;NYU Grossman Sch Med, Dept Surg, New York, NY USA.;NYU Langone Hlth, New York, NY USA.
van Der Meulen, Jan H. P. (författare)
London Sch Hyg & Trop Med, Dept Hlth Serv Res & Policy, London, England.
Sapisochin, Gonzalo (författare)
Univ Toronto, Univ Hlth Network, Multiorgan Transplant Program, Toronto, ON, Canada.
Wallace, David (författare)
Kings Coll Hosp NHS Fdn Trust, Inst Liver Studies, London, England.;London Sch Hyg & Trop Med, Dept Hlth Serv Res & Policy, London, England.
visa färre...
 (creator_code:org_t)
2023-02-16
2023
Engelska.
Ingår i: Liver international. - : Wiley-Blackwell. - 1478-3223 .- 1478-3231. ; 43:5, s. 1107-1119
Relaterad länk:
https://urn.kb.se/re...
visa fler...
https://doi.org/10.1...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background and Aims: Identifying international differences in utilization and outcomes of liver transplantation (LT) after donation after circulatory death (DCD) donation provides a unique opportunity for benchmarking and population-level insight.Methods: Adult (>= 18 years) LT data between 2008 and 2018 from the UK and US were used to assess mortality and graft failure after DCD LT. We used time-dependent Cox-regression methods to estimate hazard ratios (HR) for risk-adjusted short-term (0-90 days) and longer-term (90 days-5 years) outcomes.Results: One-thousand five-hundred-and-sixty LT receipts from the UK and 3426 from the US were included. Over the study period, the use of DCD livers increased from 15.7% to 23.9% in the UK compared to 5.1% to 7.6% in the US. In the UK, DCD donors were older (UK:51 vs. US:33 years) with longer cold ischaemia time (UK: 437 vs. US: 333 min). Recipients in the US had higher Model for End-stage Liver Disease (MELD) scores, higher body mass index, higher proportions of ascites, encephalopathy, diabetes and previous abdominal surgeries. No difference in the risk-adjusted short-term mortality or graft failure was observed between the countries. In the longer-term (90 days-5 years), the UK had lower mortality and graft failure (adj.mortality HR:UK: 0.63 (95% CI: 0.49-0.80); graft failure HR: UK: 0.72, 95% CI: 0.58-0.91). The cumulative incidence of retransplantation was higher in the UK (5 years: UK: 11.9% vs. 4.6%; p < .001).Conclusions: For those receiving a DCD LT, longer-term post-transplant outcomes in the UK are superior to the US, however, significant differences in recipient illness, graft quality and access to retransplantation were seen between the two countries.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

Nyckelord

liver transplant
NHSBT
outcomes
UNOS

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy