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Cytotoxicity of dig...
Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells
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- Johansson, Senia (författare)
- Uppsala universitet,Avdelningen för farmakognosi
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- Lindholm, Petra (författare)
- Uppsala universitet,Avdelningen för farmakognosi
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- Gullbo, Joachim (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Cancer Pharmacology and Informatics
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visa fler...
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- Larsson, Rolf (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Cancer Pharmacology and Informatics
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- Bohlin, Lars (författare)
- Uppsala universitet,Avdelningen för farmakognosi
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- Claeson, Per (författare)
- Uppsala universitet,Avdelningen för farmakognosi
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visa färre...
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(creator_code:org_t)
- 2001
- 2001
- Engelska.
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Ingår i: Anti-Cancer Drugs. - 0959-4973 .- 1473-5741. ; 12:5, s. 475-83
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The saponin digitonin, the aglycone digitoxigenin and five cardiac glycosides were evaluated for cytotoxicity using primary cultures of tumor cells from patients and a human cell line panel (representing different cytotoxic drug-resistance patterns). Of these seven compounds, proscillaridin A was the most potent (IC(50): 6.4--76 nM), followed by digitoxin, and then ouabain, digoxin, lanatoside C, digitoxigenin and digitonin. Correlation analysis of the log IC(50) values for the cell lines in the panel showed that compound cytotoxicity was only slightly influenced by resistance mechanisms that involved P-glycoprotein, topoisomerase II, multidrug resistance-associated protein and glutathione-mediated drug resistance. Digitoxin and digoxin expressed selective toxicity against solid tumor cells from patients, while proscillaridin A expressed no selective toxicity against either solid or hematological tumor cells. The results revealed marked differences in cytotoxicity between the cardiac glycosides, both in potency and selectivity, and modes of action for cytotoxicity that differ from that of commonly used anticancer drugs.
Nyckelord
- Cytotoxicity drug screening
- digitalis glycosides
- digitonin
- digitoxigenin
- digitoxin
- digoxin
- lanatoside C
- ouabain
- proscillaridin A
- tumor cell lines
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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