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The association bet...
The association between autoantibodies and risk for venous thromboembolic events among patients with rheumatoid arthritis
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- Westerlind, Helga (författare)
- Karolinska Institutet
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- Kastbom, Alf, 1978- (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Rönnelid, Johan (författare)
- Uppsala universitet,Vaskulärbiologi,Uppsala Univ, Sweden
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- Hansson, Monika (författare)
- Karolinska Institutet
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- Alfredsson, Lars (författare)
- Karolinska Institutet
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- Mathsson Alm, Linda (författare)
- Uppsala universitet,Vaskulärbiologi,Uppsala Univ, Sweden; Thermo Fisher Sci, Sweden
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- Serre, Guy (författare)
- Univ Toulouse 3, Inst Toulousain Malad Infect & Inflammatoires INF, UMR 1291, Inserm, Toulouse, France.
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- Cornillet, Martin (författare)
- Univ Toulouse 3, Inst Toulousain Malad Infect & Inflammatoires INF, UMR 1291, Inserm, Toulouse, France.
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- Holmdahl, Rikard (författare)
- Karolinska Institutet
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- Skriner, Karl (författare)
- Charite Univ Med Berlin, Dept Rheumatol & Clin Immunol, Rheumatol Forschungslab AG Skriner, Charite Campus Mitte, Berlin, Germany.;Leibniz Inst, German Rheumatism Res Ctr, D-10117 Berlin, Germany.
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- Bang, Holger (författare)
- ORGENTEC Diagnostika GmbH, Mainz, Germany.
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- Klareskog, Lars (författare)
- Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden.
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- Saevarsdottir, Saedis (författare)
- Karolinska Institutet
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- Lundberg, Karin (författare)
- Karolinska Institutet
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- Gronwall, Caroline (författare)
- Karolinska Institutet
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- Askling, Johan (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-10-18
- 2023
- Engelska.
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Ingår i: Rheumatology. - : Oxford University Press. - 1462-0324 .- 1462-0332. ; 62:6, s. 2106-2112
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives To assess the association between venous thromboembolic (VTE) events and autoantibodies, following patients from RA diagnosis, measuring occurrence, levels and collective load of different autoantibodies against post-translational protein modifications, in particular recognizing citrullination (e.g. citrullinated fibrinogen) and RF by isotype. Methods A cohort of 2814 patients with newly diagnosed RA were followed for incident VTE through register linkages. Sera from RA diagnosis were centrally analysed for antibodies to second generation cyclic citrullinated peptides (anti-CCP2), 20 anti-citrullinated protein antibody (ACPA) fine-specificities, antibodies to additional protein modifications (carbamylation and acetylation) and RF by isotype. Association between baseline serology status and future VTE was analysed using Cox regression adjusted for age, sex and calendar period of RA diagnosis, overall and stratified by anti-CCP2 and RF positivity. Results During a median 16 years of follow-up, 213 first-ever VTE events were registered (5.0/1000 person-years). IgG anti-CCP2 (present in 65% of cohort) associated with VTE (hazard ratio [HR] = 1.33, 95% CI: 1.00, 1.78), in a dose-response manner. The risk of VTE increased with number of ACPA fine-specificities. IgM RF, but no other RF isotypes, associated with VTE (HR = 1.38, 95% CI: 1.04, 1.82). The associations were independent from smoking and HLA-DRB1 shared epitope alleles. None of the carbamylated or acetylated antibody reactivities associated with VTE. Conclusion Anti-CCP2, load of ACPA fine-specificities and IgM RF at RA diagnosis are associated with an increased risk of future VTE in RA. Antibodies to citrullinated fibrinogen did not differ substantially from other ACPA fine-specificities. Autoreactivity to other post-translational modifications was not associated with VTE risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- RA
- antibody
- fibrinogen
- venous thromboembolism
- risk
- cohort
- Sweden
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Westerlind, Helg ...
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Kastbom, Alf, 19 ...
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Rönnelid, Johan
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Hansson, Monika
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Alfredsson, Lars
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Mathsson Alm, Li ...
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Serre, Guy
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Cornillet, Marti ...
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Holmdahl, Rikard
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Skriner, Karl
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Bang, Holger
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Klareskog, Lars
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Saevarsdottir, S ...
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Lundberg, Karin
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Gronwall, Caroli ...
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Askling, Johan
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
- Artiklar i publikationen
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Rheumatology
- Av lärosätet
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Uppsala universitet
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Linköpings universitet
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Karolinska Institutet