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Sex differences in ...
Sex differences in childhood cancer risk among children with major birth defects : a Nordic population-based nested case-control study
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- Daltveit, Dagrun Slettebo (författare)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Pb 7804, N-5020 Bergen, Norway.;Haukeland Hosp, Surg Clin, Norwegian Qual Registry Cleft Lip & Palate, Bergen, Norway.
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- Klungsoyr, Kari (författare)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Pb 7804, N-5020 Bergen, Norway.;Norwegian Inst Publ Hlth, Div Mental & Phys Hlth, Bergen, Norway.
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- Engeland, Anders (författare)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Pb 7804, N-5020 Bergen, Norway.;Norwegian Inst Publ Hlth, Div Mental & Phys Hlth, Bergen, Norway.
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- Ekbom, Anders (författare)
- Karolinska Institutet
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- Gissler, Mika (författare)
- Karolinska Institutet
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- Glimelius, Ingrid, 1975- (författare)
- Karolinska Institutet,Uppsala universitet,Cancerprecisionsmedicin,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.
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- Grotmol, Tom (författare)
- Canc Registry Norway, Oslo, Norway.
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- Madanat-Harjuoja, Laura (författare)
- Finnish Canc Registry, Canc Soc Finland, Helsinki, Finland.;Dana Farber Canc Inst, Boston Childrens Canc & Blood Disorders Ctr, Boston, MA 02115 USA.
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- Ording, Anne Gulbech (författare)
- Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark.;Aarhus Univ, Aarhus, Denmark.
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- Sorensen, Henrik Toft (författare)
- Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark.;Aarhus Univ, Aarhus, Denmark.
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- Troisi, Rebecca (författare)
- NCI, Transdiv Res Program, Div Canc Epidemiol & Genet, Rockville, MD USA.
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- Bjorge, Tone (författare)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Pb 7804, N-5020 Bergen, Norway.;Canc Registry Norway, Oslo, Norway.
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Univ Bergen, Dept Global Publ Hlth & Primary Care, Pb 7804, N-5020 Bergen, Norway;Haukeland Hosp, Surg Clin, Norwegian Qual Registry Cleft Lip & Palate, Bergen, Norway. Univ Bergen, Dept Global Publ Hlth & Primary Care, Pb 7804, N-5020 Bergen, Norway.;Norwegian Inst Publ Hlth, Div Mental & Phys Hlth, Bergen, Norway. (creator_code:org_t)
- 2022-09-30
- 2023
- Engelska.
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Ingår i: International Journal of Epidemiology. - : Oxford University Press. - 0300-5771 .- 1464-3685. ; 52:2, s. 450-465
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Childhood cancer is more common among children with birth defects, suggesting a common aetiology. Whether this association differs by sex is unclear. Methods We performed a population-based nested case-control study using nationwide health registries in four Nordic countries. We included 21 898 cancer cases (0-19 years) and 218 980 matched population controls, born 1967-2014. Associations between childhood cancer and major birth defects were calculated as odds ratios (ORs) with 95% confidence intervals (CIs) using logistic regression models. Effect modification was evaluated using a counterfactual framework to estimate confidence intervals and P-values for the natural indirect effects. Results Birth defects were present for 5.1% (1117/21 898) of childhood cancer cases and 2.2% (4873/218 980) of controls; OR of cancer was higher for chromosomal (OR = 10, 95% CI = 8.6-12) than for non-chromosomal defects (OR = 1.9, 95% CI = 1.8-2.1), strongest between genetic syndromes/microdeletion and renal tumours, Down syndrome and leukaemia, and nervous system defects and central nervous system tumours. The association between birth defects and cancer was stronger among females (OR = 2.8, 95% CI = 2.6-3.1) than males (OR = 2.1, 95% CI = 1.9-2.2, P-interaction <0.001). Male sex was an independent risk factor for childhood cancer, but very little of the overall association between sex and childhood cancer was mediated through birth defects (4.8%, P-NIE <0.001), although more at younger ages (10% below years and 28% below 1 year). Conclusions The birth defect-cancer associations were generally stronger among females than males. Birth defects did not act as a strong mediator for the modest differences in childhood cancer risk by sex, suggesting that other biological pathways are involved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Childhood cancer
- birth defects
- congenital anomalies
- sex differences
- cancer risk
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Daltveit, Dagrun ...
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Klungsoyr, Kari
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Engeland, Anders
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Ekbom, Anders
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Gissler, Mika
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Glimelius, Ingri ...
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Grotmol, Tom
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Madanat-Harjuoja ...
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Ording, Anne Gul ...
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Sorensen, Henrik ...
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Troisi, Rebecca
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Bjorge, Tone
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