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Antioxidants, miner...
Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis : A Mendelian randomization study
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- Chen, Jie (författare)
- Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China.;Zhejiang Univ, Sch Med, Ctr Global Hlth, Hangzhou, Peoples R China.;Zhejiang Univ, Sch Med, Sch Publ Hlth, Dept Big Data Hlth Sci, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China.
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- Ruan, Xixian (författare)
- Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China.
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- Yuan, Shuai (författare)
- Karolinska Institutet
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- Deng, Minzi (författare)
- Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China.
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- Zhang, Han (författare)
- Zhejiang Univ, Sch Med, Sch Publ Hlth, Dept Big Data Hlth Sci, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China.
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- Sun, Jing (författare)
- Zhejiang Univ, Sch Med, Sch Publ Hlth, Dept Big Data Hlth Sci, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China.
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- Yu, Lili (författare)
- Zhejiang Univ, Sch Med, Sch Publ Hlth, Dept Big Data Hlth Sci, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China.
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- Satsangi, Jack (författare)
- Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Expt Med Div,Translat Gastroenterol Unit, Oxford, England.
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- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden
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- Therdoratou, Evropi (författare)
- Univ Edinburgh, Usher Inst, Ctr Global Hlth, Edinburgh, Scotland.;Univ Edinburgh, Med Res Council Inst Genet & Canc, Canc Res UK Edinburgh Ctr, Edinburgh, Scotland.
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- Wang, Xiaoyan (författare)
- Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China.
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- Li, Xue (författare)
- Zhejiang Univ, Sch Med, Sch Publ Hlth, Dept Big Data Hlth Sci, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Sch Publ Hlth, Hangzhou, Peoples R China.
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Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China;Zhejiang Univ, Sch Med, Ctr Global Hlth, Hangzhou, Peoples R China.;Zhejiang Univ, Sch Med, Sch Publ Hlth, Dept Big Data Hlth Sci, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China. Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China. (creator_code:org_t)
- 2023-01-16
- 2023
- Engelska.
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Ingår i: Alimentary Pharmacology and Therapeutics. - : John Wiley & Sons. - 0269-2813 .- 1365-2036. ; 57:4, s. 399-408
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BackgroundEvidence for antioxidants, minerals and vitamins in relation to the risk of Crohn's disease (CD) and ulcerative colitis (UC) is limited and inconsistent. This mendelian randomization (MR) study aimed to examine the causal associations of circulating levels of antioxidants, minerals and vitamins with CD and UC.MethodsSingle-nucleotide polymorphisms associated with antioxidants (beta-carotene, lycopene and uric acid), minerals (copper, calcium, iron, magnesium, phosphorus, zinc and selenium), and vitamins (folate, vitamins A, B6, B12, C, D, E and K1) were employed as instrumental variables. Genetic associations with CD and UC were extracted from the UK Biobank, the FinnGen study and the International Inflammatory Bowel Disease Genetics Consortium. The inverse variance weighted method and sensitivity analyses were performed.ResultsGenetically predicted higher lycopene (OR = 0.94, 95% CI: 0.91–0.97), vitamins D (OR = 0.65, 95% CI: 0.54–0.79) and K1 (OR = 0.93, 95% CI: 0.90–0.97) levels were inversely associated with CD risk, whereas genetically predicted higher magnesium (OR = 1.53, 95% CI: 1.23–1.90) levels were positively associated with CD risk. Higher levels of genetically predicted lycopene (OR = 0.91, 95% CI: 0.88–0.95), phosphorus (OR = 0.69, 95% CI: 0.58–0.82), selenium (OR = 0.91, 95% CI: 0.85–0.97), zinc (OR = 0.91, 95% CI: 0.89–0.94), folate (OR = 0.71, 95% CI: 0.56–0.92) and vitamin E (OR = 0.78, 95% CI: 0.69–0.88) were associated with reduced UC risk, whereas genetically predicted high levels of calcium (OR = 1.46, 95% CI: 1.22–1.76) and magnesium (OR = 1.24, 95% CI: 1.03–1.49) were associated with increased risk of UC.ConclusionsOur study provided evidence that circulating levels of antioxidants, minerals and vitamins might be causally linked to the development of IBD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- antioxidants
- Crohn's disease
- Mendelian randomization analysis
- minerals
- ulcerative colitis
- vitamins
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Chen, Jie
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Ruan, Xixian
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Yuan, Shuai
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Deng, Minzi
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Zhang, Han
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Sun, Jing
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Yu, Lili
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Satsangi, Jack
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Larsson, Susanna ...
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Therdoratou, Evr ...
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Wang, Xiaoyan
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Li, Xue
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Alimentary Pharm ...
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Uppsala universitet
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Karolinska Institutet