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  • Kruse, BastianOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)

CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Springer Nature,2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-512802
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512802URI
  • https://doi.org/10.1038/s41586-023-06199-xDOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Title in Web of Science: CD4(+) T cell-induced inflammatory cell death controls immune-evasive tumours
  • Most clinically applied cancer immunotherapies rely on the ability of CD8+ cytolytic T cells to directly recognize and kill tumour cells1,2,3. These strategies are limited by the emergence of major histocompatibility complex (MHC)-deficient tumour cells and the formation of an immunosuppressive tumour microenvironment4,5,6. The ability of CD4+ effector cells to contribute to antitumour immunity independently of CD8+ T cells is increasingly recognized, but strategies to unleash their full potential remain to be identified7,8,9,10. Here, we describe a mechanism whereby a small number of CD4+ T cells is sufficient to eradicate MHC-deficient tumours that escape direct CD8+ T cell targeting. The CD4+ effector T cells preferentially cluster at tumour invasive margins where they interact with MHC-II+CD11c+ antigen-presenting cells. We show that T helper type 1 cell-directed CD4+ T cells and innate immune stimulation reprogramme the tumour-associated myeloid cell network towards interferon-activated antigen-presenting and iNOS-expressing tumouricidal effector phenotypes. Together, CD4+ T cells and tumouricidal myeloid cells orchestrate the induction of remote inflammatory cell death that indirectly eradicates interferon-unresponsive and MHC-deficient tumours. These results warrant the clinical exploitation of this ability of CD4+ T cells and innate immune stimulators in a strategy to complement the direct cytolytic activity of CD8+ T cells and natural killer cells and advance cancer immunotherapies.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Buzzai, Anthony C.Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Shridhar, NaveenOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Braun, Andreas D.Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Gellert, SusanOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Knauth, KristinOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Pozniak, JoannaVIB, Ctr Canc Biol, Lab Mol Canc Biol, Leuven, Belgium.;Katholieke Univ Leuven, Dept Oncol, Lab Mol Canc Biol, Leuven, Belgium. (författare)
  • Peters, JohannesOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Dittmann, PaulinaOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Mengoni, MiriamOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • van der Sluis, Tetje CorneliaOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Höhn, SimonOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Antoranz, AsierKatholieke Univ Leuven, Dept Imaging & Pathol, Translat Cell & Tissue Res, Leuven, Belgium. (författare)
  • Krone, AnnaOtto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Fu, YanOtto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Yu, Di,1985-Uppsala universitet,Cancerimmunterapi(Swepub:uu)diayu422 (författare)
  • Essand, MagnusUppsala universitet,Cancerimmunterapi(Swepub:uu)magnessa (författare)
  • Geffers, RobertHelmholtz Ctr Infect Res, Braunschweig, Germany. (författare)
  • Mougiakakos, DimitriosOtto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.;Otto von Guericke Univ, Dept Hematol, Univ Hosp, Magdeburg, Germany. (författare)
  • Kahlfuss, SaschaOtto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Kashkar, HamidUniv Cologne, Inst Mol Immunol, Ctr Mol Med Cologne, Cologne, Germany.;Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany. (författare)
  • Gaffal, EvelynOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Bosisio, Francesca M.UZ Leuven, Dept Pathol, Leuven, Belgium. (författare)
  • Bechter, OliverUZ Leuven, Dept Gen Med Oncol, Leuven, Belgium. (författare)
  • Rambow, FlorianUniv Hosp Essen, Inst Med IKIM, Dept Appl Computat Canc Res, Essen, Germany.;Univ Duisburg Essen, Essen, Germany. (författare)
  • Marine, Jean-ChristopheVIB, Ctr Canc Biol, Lab Mol Canc Biol, Leuven, Belgium.;Katholieke Univ Leuven, Dept Oncol, Lab Mol Canc Biol, Leuven, Belgium. (författare)
  • Kastenmüller, WolfgangInst Syst Immunol, Wurzburg, Germany. (författare)
  • Müller, Andreas J.Otto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Tüting, ThomasOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. (författare)
  • Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.VIB, Ctr Canc Biol, Lab Mol Canc Biol, Leuven, Belgium.;Katholieke Univ Leuven, Dept Oncol, Lab Mol Canc Biol, Leuven, Belgium. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature: Springer Nature618:7967, s. 1033-10400028-08361476-4687

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