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CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours

Kruse, Bastian (författare)
Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
Buzzai, Anthony C. (författare)
Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
Shridhar, Naveen (författare)
Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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Braun, Andreas D. (författare)
Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
Gellert, Susan (författare)
Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
Knauth, Kristin (författare)
Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
Pozniak, Joanna (författare)
VIB, Ctr Canc Biol, Lab Mol Canc Biol, Leuven, Belgium.;Katholieke Univ Leuven, Dept Oncol, Lab Mol Canc Biol, Leuven, Belgium.
Peters, Johannes (författare)
Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
Dittmann, Paulina (författare)
Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
Mengoni, Miriam (författare)
Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
van der Sluis, Tetje Cornelia (författare)
Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
Höhn, Simon (författare)
Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
Antoranz, Asier (författare)
Katholieke Univ Leuven, Dept Imaging & Pathol, Translat Cell & Tissue Res, Leuven, Belgium.
Krone, Anna (författare)
Otto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
Fu, Yan (författare)
Otto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
Yu, Di, 1985- (författare)
Uppsala universitet,Cancerimmunterapi
Essand, Magnus (författare)
Uppsala universitet,Cancerimmunterapi
Geffers, Robert (författare)
Helmholtz Ctr Infect Res, Braunschweig, Germany.
Mougiakakos, Dimitrios (författare)
Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.;Otto von Guericke Univ, Dept Hematol, Univ Hosp, Magdeburg, Germany.
Kahlfuss, Sascha (författare)
Otto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
Kashkar, Hamid (författare)
Univ Cologne, Inst Mol Immunol, Ctr Mol Med Cologne, Cologne, Germany.;Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany.
Gaffal, Evelyn (författare)
Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
Bosisio, Francesca M. (författare)
UZ Leuven, Dept Pathol, Leuven, Belgium.
Bechter, Oliver (författare)
UZ Leuven, Dept Gen Med Oncol, Leuven, Belgium.
Rambow, Florian (författare)
Univ Hosp Essen, Inst Med IKIM, Dept Appl Computat Canc Res, Essen, Germany.;Univ Duisburg Essen, Essen, Germany.
Marine, Jean-Christophe (författare)
VIB, Ctr Canc Biol, Lab Mol Canc Biol, Leuven, Belgium.;Katholieke Univ Leuven, Dept Oncol, Lab Mol Canc Biol, Leuven, Belgium.
Kastenmüller, Wolfgang (författare)
Inst Syst Immunol, Wurzburg, Germany.
Müller, Andreas J. (författare)
Otto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
Tüting, Thomas (författare)
Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
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Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. VIB, Ctr Canc Biol, Lab Mol Canc Biol, Leuven, Belgium.;Katholieke Univ Leuven, Dept Oncol, Lab Mol Canc Biol, Leuven, Belgium. (creator_code:org_t)
Springer Nature, 2023
2023
Engelska.
Ingår i: Nature. - : Springer Nature. - 0028-0836 .- 1476-4687. ; 618:7967, s. 1033-1040
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Most clinically applied cancer immunotherapies rely on the ability of CD8+ cytolytic T cells to directly recognize and kill tumour cells1,2,3. These strategies are limited by the emergence of major histocompatibility complex (MHC)-deficient tumour cells and the formation of an immunosuppressive tumour microenvironment4,5,6. The ability of CD4+ effector cells to contribute to antitumour immunity independently of CD8+ T cells is increasingly recognized, but strategies to unleash their full potential remain to be identified7,8,9,10. Here, we describe a mechanism whereby a small number of CD4+ T cells is sufficient to eradicate MHC-deficient tumours that escape direct CD8+ T cell targeting. The CD4+ effector T cells preferentially cluster at tumour invasive margins where they interact with MHC-II+CD11c+ antigen-presenting cells. We show that T helper type 1 cell-directed CD4+ T cells and innate immune stimulation reprogramme the tumour-associated myeloid cell network towards interferon-activated antigen-presenting and iNOS-expressing tumouricidal effector phenotypes. Together, CD4+ T cells and tumouricidal myeloid cells orchestrate the induction of remote inflammatory cell death that indirectly eradicates interferon-unresponsive and MHC-deficient tumours. These results warrant the clinical exploitation of this ability of CD4+ T cells and innate immune stimulators in a strategy to complement the direct cytolytic activity of CD8+ T cells and natural killer cells and advance cancer immunotherapies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Immunologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Immunology (hsv//eng)

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