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The association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life : results from the Burden of Obstructive Lung Disease (BOLD) study
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- Knox-Brown, Ben (författare)
- Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.
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- Patel, Jaymini (författare)
- Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.
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- Potts, James (författare)
- Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.
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- Ahmed, Rana (författare)
- Epidemiol Lab Epilab, Khartoum, Sudan.
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- Aquart-Stewart, Althea (författare)
- UWI, Dept Med, Mona, Jamaica.
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- Barbara, Cristina (författare)
- Univ Lisbon, Fac Med, Inst Saude Ambiental, Lisbon, Portugal.;Ctr Hosp Univ Lisboa Norte, Serv Pneumol, Lisbon, Portugal.
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- Buist, A. Sonia (författare)
- Oregon Hlth & Sci Univ, Portland, OR USA.
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- Cherkaski, Hamid Hacene (författare)
- Univ Badji Mokhtar Annaba, Fac Med Annaba, Dept Pneumol, Annaba, Algeria.
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- Denguezli, Meriam (författare)
- Univ Monastir, Fac Med Dent Monastir, Ave Avicenne, Monastir, Tunisia.
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- Elbiaze, Mohammed (författare)
- Mohammed Ben Abdellah Univ, Univ Hosp, Fac Med, Dept Resp Med, Fes, Morocco.,Maastricht Univ, Dept Resp Med, Med Ctr, Maastricht, Netherlands.;CIRO, Dept Res & Educ, Horn, Netherlands.
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- Erhabor, Gregory E. (författare)
- Obafemi Awolowo Univ, Ife, Osun, Nigeria.
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- Franssen, Frits M. E. (författare)
- Maastricht Univ, Dept Resp Med, Med Ctr, Maastricht, Netherlands.;CIRO, Dept Res & Educ, Horn, Netherlands.,Maastricht Univ, Dept Resp Med, Med Ctr, Maastricht, Netherlands.;Ludwig Boltzmann Inst Lung Hlth, Vienna, Austria.
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- Al Ghobain, Mohammed (författare)
- King Saud Bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, King Abdulaziz Med City, Minist Natl Guard Hlth Affairs, Riyadh, Saudi Arabia.
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- Gislason, Thorarinn (författare)
- Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning,Arbets- och miljömedicin,Klinisk fysiologi,Uppsala Univ, Dept Med Sci Resp Allergy & Sleep Res, Uppsala, Sweden.
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- Kocabas, Ali (författare)
- Cukurova Univ, Dept Chest Dis, Sch Med, Adana, Turkiye.
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- Mannino, David (författare)
- Univ Kentucky, Lexington, KY USA.;COPD Fdn, Miami, FL USA.
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- Marks, Guy (författare)
- Woolcock Inst Med Res, Sydney, NSW, Australia.;Univ Sydney, Sydney, NSW, Australia.;Univ New South Wales, Sydney, NSW, Australia.
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- Mortimer, Kevin (författare)
- Univ Cambridge, Cambridge, England.;Liverpool Univ Hosp NHS Fdn Trust, Liverpool, England.
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- Nafees, Asaad Ahmed (författare)
- Aga Khan Univ, Dept Community Hlth Sci, Karachi, Pakistan.
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- Obaseki, Daniel (författare)
- Obafemi Awolowo Univ, Ife, Osun, Nigeria.
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- Paraguas, Stefanni Nonna M. (författare)
- Philippine Coll Chest Phys, Quezon City, Philippines.;Philippine Heart Ctr, Quezon City, Philippines.
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- Loh, Li Cher (författare)
- RCSI & UCD Malaysia Campus, George Town, Malaysia.
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- Rashid, Abdul (författare)
- RCSI & UCD Malaysia Campus, George Town, Malaysia.
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- Salvi, Sundeep (författare)
- Pulmocare Res & Educ PURE Fdn, Pune, India.;Symbiosis Int Deemed Univ, Pune, India.,Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.
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- Seemungal, Terence (författare)
- Univ West Indies, Fac Med Sci, St Augustine, Trinidad Tobago.
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- Studnicka, Michael (författare)
- Paracelsus Med Univ Salzburg, Univ Clin Pneumol, Salzburg, Austria.
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- Tan, Wan C. (författare)
- Univ British Columbia, Ctr Heart Lung Innovat, Vancouver, BC, Canada.
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- Wouters, Emiel F. M. (författare)
- Maastricht Univ, Dept Resp Med, Med Ctr, Maastricht, Netherlands.;Ludwig Boltzmann Inst Lung Hlth, Vienna, Austria.
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- Abozid, Hazim (författare)
- Ludwig Boltzmann Inst Lung Hlth, Vienna, Austria.
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- Mueller, Alexander (författare)
- Ludwig Boltzmann Inst Lung Hlth, Vienna, Austria.
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- Burney, Peter (författare)
- Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.
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- Amaral, Andre F. S. (författare)
- Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.
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Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England Epidemiol Lab Epilab, Khartoum, Sudan. (creator_code:org_t)
- BioMed Central (BMC), 2023
- 2023
- Engelska.
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Ingår i: Respiratory Research. - : BioMed Central (BMC). - 1465-9921 .- 1465-993X. ; 24:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BackgroundSpirometric small airways obstruction (SAO) is common in the general population. Whether spirometric SAO is associated with respiratory symptoms, cardiometabolic diseases, and quality of life (QoL) is unknown.MethodsUsing data from the Burden of Obstructive Lung Disease study (N = 21,594), we defined spirometric SAO as the mean forced expiratory flow rate between 25 and 75% of the FVC (FEF25-75) less than the lower limit of normal (LLN) or the forced expiratory volume in 3 s to FVC ratio (FEV3/FVC) less than the LLN. We analysed data on respiratory symptoms, cardiometabolic diseases, and QoL collected using standardised questionnaires. We assessed the associations with spirometric SAO using multivariable regression models, and pooled site estimates using random effects meta-analysis. We conducted identical analyses for isolated spirometric SAO (i.e. with FEV1/FVC ≥ LLN).ResultsAlmost a fifth of the participants had spirometric SAO (19% for FEF25-75; 17% for FEV3/FVC). Using FEF25-75, spirometric SAO was associated with dyspnoea (OR = 2.16, 95% CI 1.77–2.70), chronic cough (OR = 2.56, 95% CI 2.08–3.15), chronic phlegm (OR = 2.29, 95% CI 1.77–4.05), wheeze (OR = 2.87, 95% CI 2.50–3.40) and cardiovascular disease (OR = 1.30, 95% CI 1.11–1.52), but not hypertension or diabetes. Spirometric SAO was associated with worse physical and mental QoL. These associations were similar for FEV3/FVC. Isolated spirometric SAO (10% for FEF25-75; 6% for FEV3/FVC), was also associated with respiratory symptoms and cardiovascular disease.ConclusionSpirometric SAO is associated with respiratory symptoms, cardiovascular disease, and QoL. Consideration should be given to the measurement of FEF25-75 and FEV3/FVC, in addition to traditional spirometry parameters.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Spirometry
- Small airways obstruction
- Symptoms
- Cardiovascular disease
- Quality of life
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Knox-Brown, Ben
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Patel, Jaymini
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Potts, James
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Ahmed, Rana
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Aquart-Stewart, ...
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Barbara, Cristin ...
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Buist, A. Sonia
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Cherkaski, Hamid ...
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Denguezli, Meria ...
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Elbiaze, Mohamme ...
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Erhabor, Gregory ...
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Franssen, Frits ...
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Al Ghobain, Moha ...
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Gislason, Thorar ...
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Janson, Christer
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Kocabas, Ali
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Mannino, David
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Marks, Guy
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Mortimer, Kevin
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Nafees, Asaad Ah ...
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Obaseki, Daniel
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Paraguas, Stefan ...
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Loh, Li Cher
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Rashid, Abdul
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Salvi, Sundeep
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Seemungal, Teren ...
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Studnicka, Micha ...
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Tan, Wan C.
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Wouters, Emiel F ...
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Abozid, Hazim
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Mueller, Alexand ...
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Burney, Peter
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Amaral, Andre F. ...
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