Search: WFRF:(Mortimer James) >
The association of ...
-
Knox-Brown, BenImperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.
(author)
The association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life : results from the Burden of Obstructive Lung Disease (BOLD) study
- Article/chapterEnglish2023
Publisher, publication year, extent ...
-
BioMed Central (BMC),2023
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-512806
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512806URI
-
https://doi.org/10.1186/s12931-023-02450-1DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-506649URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
BackgroundSpirometric small airways obstruction (SAO) is common in the general population. Whether spirometric SAO is associated with respiratory symptoms, cardiometabolic diseases, and quality of life (QoL) is unknown.MethodsUsing data from the Burden of Obstructive Lung Disease study (N = 21,594), we defined spirometric SAO as the mean forced expiratory flow rate between 25 and 75% of the FVC (FEF25-75) less than the lower limit of normal (LLN) or the forced expiratory volume in 3 s to FVC ratio (FEV3/FVC) less than the LLN. We analysed data on respiratory symptoms, cardiometabolic diseases, and QoL collected using standardised questionnaires. We assessed the associations with spirometric SAO using multivariable regression models, and pooled site estimates using random effects meta-analysis. We conducted identical analyses for isolated spirometric SAO (i.e. with FEV1/FVC ≥ LLN).ResultsAlmost a fifth of the participants had spirometric SAO (19% for FEF25-75; 17% for FEV3/FVC). Using FEF25-75, spirometric SAO was associated with dyspnoea (OR = 2.16, 95% CI 1.77–2.70), chronic cough (OR = 2.56, 95% CI 2.08–3.15), chronic phlegm (OR = 2.29, 95% CI 1.77–4.05), wheeze (OR = 2.87, 95% CI 2.50–3.40) and cardiovascular disease (OR = 1.30, 95% CI 1.11–1.52), but not hypertension or diabetes. Spirometric SAO was associated with worse physical and mental QoL. These associations were similar for FEV3/FVC. Isolated spirometric SAO (10% for FEF25-75; 6% for FEV3/FVC), was also associated with respiratory symptoms and cardiovascular disease.ConclusionSpirometric SAO is associated with respiratory symptoms, cardiovascular disease, and QoL. Consideration should be given to the measurement of FEF25-75 and FEV3/FVC, in addition to traditional spirometry parameters.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Patel, JayminiImperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.
(author)
-
Potts, JamesImperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.
(author)
-
Ahmed, RanaEpidemiol Lab Epilab, Khartoum, Sudan.
(author)
-
Aquart-Stewart, AltheaUWI, Dept Med, Mona, Jamaica.
(author)
-
Barbara, CristinaUniv Lisbon, Fac Med, Inst Saude Ambiental, Lisbon, Portugal.;Ctr Hosp Univ Lisboa Norte, Serv Pneumol, Lisbon, Portugal.
(author)
-
Buist, A. SoniaOregon Hlth & Sci Univ, Portland, OR USA.
(author)
-
Cherkaski, Hamid HaceneUniv Badji Mokhtar Annaba, Fac Med Annaba, Dept Pneumol, Annaba, Algeria.
(author)
-
Denguezli, MeriamUniv Monastir, Fac Med Dent Monastir, Ave Avicenne, Monastir, Tunisia.
(author)
-
Elbiaze, MohammedMohammed Ben Abdellah Univ, Univ Hosp, Fac Med, Dept Resp Med, Fes, Morocco.,Maastricht Univ, Dept Resp Med, Med Ctr, Maastricht, Netherlands.;CIRO, Dept Res & Educ, Horn, Netherlands.
(author)
-
Erhabor, Gregory E.Obafemi Awolowo Univ, Ife, Osun, Nigeria.
(author)
-
Franssen, Frits M. E.Maastricht Univ, Dept Resp Med, Med Ctr, Maastricht, Netherlands.;CIRO, Dept Res & Educ, Horn, Netherlands.,Maastricht Univ, Dept Resp Med, Med Ctr, Maastricht, Netherlands.;Ludwig Boltzmann Inst Lung Hlth, Vienna, Austria.
(author)
-
Al Ghobain, MohammedKing Saud Bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, King Abdulaziz Med City, Minist Natl Guard Hlth Affairs, Riyadh, Saudi Arabia.
(author)
-
Gislason, ThorarinnLandspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
(author)
-
Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning,Arbets- och miljömedicin,Klinisk fysiologi,Uppsala Univ, Dept Med Sci Resp Allergy & Sleep Res, Uppsala, Sweden.(Swepub:uu)chrisjn
(author)
-
Kocabas, AliCukurova Univ, Dept Chest Dis, Sch Med, Adana, Turkiye.
(author)
-
Mannino, DavidUniv Kentucky, Lexington, KY USA.;COPD Fdn, Miami, FL USA.
(author)
-
Marks, GuyWoolcock Inst Med Res, Sydney, NSW, Australia.;Univ Sydney, Sydney, NSW, Australia.;Univ New South Wales, Sydney, NSW, Australia.
(author)
-
Mortimer, KevinUniv Cambridge, Cambridge, England.;Liverpool Univ Hosp NHS Fdn Trust, Liverpool, England.
(author)
-
Nafees, Asaad AhmedAga Khan Univ, Dept Community Hlth Sci, Karachi, Pakistan.
(author)
-
Obaseki, DanielObafemi Awolowo Univ, Ife, Osun, Nigeria.
(author)
-
Paraguas, Stefanni Nonna M.Philippine Coll Chest Phys, Quezon City, Philippines.;Philippine Heart Ctr, Quezon City, Philippines.
(author)
-
Loh, Li CherRCSI & UCD Malaysia Campus, George Town, Malaysia.
(author)
-
Rashid, AbdulRCSI & UCD Malaysia Campus, George Town, Malaysia.
(author)
-
Salvi, SundeepPulmocare Res & Educ PURE Fdn, Pune, India.;Symbiosis Int Deemed Univ, Pune, India.,Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.
(author)
-
Seemungal, TerenceUniv West Indies, Fac Med Sci, St Augustine, Trinidad Tobago.
(author)
-
Studnicka, MichaelParacelsus Med Univ Salzburg, Univ Clin Pneumol, Salzburg, Austria.
(author)
-
Tan, Wan C.Univ British Columbia, Ctr Heart Lung Innovat, Vancouver, BC, Canada.
(author)
-
Wouters, Emiel F. M.Maastricht Univ, Dept Resp Med, Med Ctr, Maastricht, Netherlands.;Ludwig Boltzmann Inst Lung Hlth, Vienna, Austria.
(author)
-
Abozid, HazimLudwig Boltzmann Inst Lung Hlth, Vienna, Austria.
(author)
-
Mueller, AlexanderLudwig Boltzmann Inst Lung Hlth, Vienna, Austria.
(author)
-
Burney, PeterImperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.
(author)
-
Amaral, Andre F. S.Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.
(author)
-
Imperial Coll London, Natl Heart & Lung Inst, 1B Manresa Rd, London SW3 6LR, England.Epidemiol Lab Epilab, Khartoum, Sudan.
(creator_code:org_t)
Related titles
-
In:Respiratory Research: BioMed Central (BMC)24:11465-99211465-993X
Internet link
Find in a library
To the university's database
- By the author/editor
-
Knox-Brown, Ben
-
Patel, Jaymini
-
Potts, James
-
Ahmed, Rana
-
Aquart-Stewart, ...
-
Barbara, Cristin ...
-
show more...
-
Buist, A. Sonia
-
Cherkaski, Hamid ...
-
Denguezli, Meria ...
-
Elbiaze, Mohamme ...
-
Erhabor, Gregory ...
-
Franssen, Frits ...
-
Al Ghobain, Moha ...
-
Gislason, Thorar ...
-
Janson, Christer
-
Kocabas, Ali
-
Mannino, David
-
Marks, Guy
-
Mortimer, Kevin
-
Nafees, Asaad Ah ...
-
Obaseki, Daniel
-
Paraguas, Stefan ...
-
Loh, Li Cher
-
Rashid, Abdul
-
Salvi, Sundeep
-
Seemungal, Teren ...
-
Studnicka, Micha ...
-
Tan, Wan C.
-
Wouters, Emiel F ...
-
Abozid, Hazim
-
Mueller, Alexand ...
-
Burney, Peter
-
Amaral, Andre F. ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nursing
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Respiratory Medi ...
- Articles in the publication
-
Respiratory Rese ...
- By the university
-
Uppsala University