Dronedarone versus sotalol in patients with atrial fibrillation: A systematic literature review and network meta-analysis

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Singh, Jagmeet P.Harvard Med Sch, Massachusetts Gen Hosp, Cardiol Div, Boston, MA USA. (author)

Dronedarone versus sotalol in patients with atrial fibrillation : A systematic literature review and network meta-analysis

Article/chapterEnglish2023

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John Wiley & Sons,2023
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LIBRIS-ID:oai:DiVA.org:uu-513050
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-513050URI
https://doi.org/10.1002/clc.24011DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:for swepub-publicationtype

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BackgroundThere are limited comparative data on safety and efficacy within commonly used Vaughan-Williams (VW) class III antiarrhythmic drugs (AADs) for maintenance of sinus rhythm in adults with atrial fibrillation (AF). HypothesisWe hypothesized that dronedarone and sotalol, two commonly prescribed VW class III AADs with class II properties, have different safety and efficacy effects in patients with nonpermanent AF. MethodsA systematic literature review was conducted searching MEDLINE (R), Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) up to June 15, 2021 (NCT05279833). Clinical trials and observational studies that evaluated safety and efficacy of dronedarone or sotalol in adults with AF were included. Bayesian random-effects network meta-analysis (NMA) was used to quantify comparative safety and efficacy. Where feasible, we performed sensitivity analyses by including only randomized controlled trials (RCTs). ResultsOf 3581 records identified through database searches, 37 unique studies (23 RCTs, 13 observational studies, and 1 nonrandomized trial) were included in the NMA. Dronedarone was associated with a statistically significantly lower risk of all-cause death versus sotalol (hazard ratio [HR] = 0.38 [95% credible interval, CrI: 0.19, 0.74]). The association was numerically similar in the sensitivity analysis (HR = 0.46 [95% CrI: 0.21, 1.02]). AF recurrence and cardiovascular death results were not significantly different between dronedarone and sotalol in all-studies and sensitivity analyses. ConclusionThe NMA findings indicate that, across all clinical trials and observational studies included, dronedarone compared with sotalol was associated with a lower risk of all-cause death, but with no difference in AF recurrence.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
antiarrhythmia agents
atrial fibrillation
dronedarone
network meta-analysis
sotalol
systematic review

Added entries (persons, corporate bodies, meetings, titles ...)

Blomström-Lundqvist, CarinaUppsala universitet,Kardiologi-arrytmi,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Dept Cardiol, Örebro, Sweden.(Swepub:uu)carinabl (author)
Turakhia, Mintu P.Stanford Univ, Ctr Digital Hlth, Dept Med Cardiovasc Med, Stanford, CA USA. (author)
Camm, A. JohnSt Georges Univ London, Cardiac Acad Grp, London, England. (author)
Fazeli, Mir SohailEvidinno Outcomes Res Inc, Vancouver, BC, Canada. (author)
Kreidieh, BahijLankenau Inst Med Res, Wynnewood, PA USA. (author)
Crotty, ChristopherEvidinno Outcomes Res Inc, Vancouver, BC, Canada. (author)
Kowey, Peter R.Lankenau Inst Med Res, Wynnewood, PA USA.;Thomas Jefferson Univ, Dept Med, Philadelphia, PA USA. (author)
Harvard Med Sch, Massachusetts Gen Hosp, Cardiol Div, Boston, MA USA.Kardiologi-arrytmi (creator_code:org_t)

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In:Clinical Cardiology: John Wiley & Sons46:6, s. 589-5970160-92891932-8737

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