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Understanding the e...
Understanding the evolution of immune genes in jawed vertebrates
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- Vinkler, Michal (författare)
- Charles Univ Prague, Fac Sci, Dept Zool, Prague, Czech Republic.,Charles University in Prague
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- Fiddaman, Steven R. (författare)
- Univ Oxford, Dept Biol, Oxford, England.,University of Oxford
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- Tesický, Martin (författare)
- Charles Univ Prague, Fac Sci, Dept Zool, Prague, Czech Republic.,Charles University in Prague
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- O'Connor, Emily A. (författare)
- Lund University,Lunds universitet,MEMEG,Biologiska institutionen,Naturvetenskapliga fakulteten,Molekylär ekologi och evolution,Forskargrupper vid Lunds universitet,CAnMove - Centrum för forskning om djurs spridning och flyttning,Department of Biology,Faculty of Science,Molecular Ecology and Evolution Lab,Lund University Research Groups,CAnMove - Centre for Animal Movement Research
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- Savage, Anna E. (författare)
- Univ Cent Florida, Dept Biol, Orlando, FL USA.,University of Central Florida
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- Lenz, Tobias L. (författare)
- Univ Hamburg, Dept Biol, Res Unit Evolutionary Immunogen, Hamburg, Germany.,University of Hamburg
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- Smith, Adrian L. (författare)
- Univ Oxford, Dept Biol, Oxford, England.,University of Oxford
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- Kaufman, Jim (författare)
- Univ Edinburgh, Inst Immunol & Infect Res, Edinburgh, Scotland.;Univ Cambridge, Dept Vet Med, Cambridge, England.,University of Edinburgh
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- Bolnick, Daniel I. (författare)
- Univ Connecticut, Dept Ecol & Evolutionary Biol, Storrs, CT USA.,University of Connecticut
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- Davies, Charli S. (författare)
- Univ East Anglia, Sch Biol Sci, Norwich, England.,University of East Anglia
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- Dedic, Neira (författare)
- Masaryk Univ, Dept Bot & Zool, Brno, Czech Republic.,Masaryk University
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- Flies, Andrew S. (författare)
- Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia.,Menzies Institute for Medical Research
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- Gomez Samblas, M. Mercedes (författare)
- Univ Granada, Dept Parasitol, Granada, Spain.,Charles University in Prague,University of Granada
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- Henschen, Amberleigh E. (författare)
- Univ Memphis, Dept Biol Sci, Memphis, TN USA.,University of Memphis
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- Novák, Karel (författare)
- Inst Anim Sci, Dept Genet & Breeding, Uhrinrves, Czech Republic.
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- Palomar, Gemma (författare)
- Jagiellonian Univ, Inst Environm Sci, Fac Biol, Krakow, Poland.,Jagiellonian University
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- Raven, Nynke (författare)
- Deakin Univ, Dept Sci Engn & Build Environm, Waurn Ponds, Vic, Australia.,Deakin University
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- Samaké, Kalifa (författare)
- Charles Univ Prague, Fac Sci, Dept Genet & Microbiol, Prague, Czech Republic.,Charles University in Prague
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- Slade, Joel (författare)
- Calif State Univ, Dept Biol, Fresno, CA USA.
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- Kuttiyarthu Veetil, Nithya (författare)
- Charles Univ Prague, Fac Sci, Dept Zool, Prague, Czech Republic.,Charles University in Prague
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- Voukali, Eleni (författare)
- Charles Univ Prague, Fac Sci, Dept Zool, Prague, Czech Republic.,Charles University in Prague
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- Höglund, Jacob (författare)
- Uppsala University,Uppsala universitet,Zooekologi
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- Richardson, David S. (författare)
- University of East Anglia
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- Westerdahl, Helena (författare)
- Lund University,Lunds universitet,MEMEG,Biologiska institutionen,Naturvetenskapliga fakulteten,Molekylär ekologi och evolution,Forskargrupper vid Lunds universitet,CAnMove - Centrum för forskning om djurs spridning och flyttning,Department of Biology,Faculty of Science,Molecular Ecology and Evolution Lab,Lund University Research Groups,CAnMove - Centre for Animal Movement Research
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Charles Univ Prague, Fac Sci, Dept Zool, Prague, Czech Republic Charles University in Prague (creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- Engelska.
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Ingår i: Journal of Evolutionary Biology. - : John Wiley & Sons. - 1010-061X .- 1420-9101. ; 36:6, s. 847-873
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Driven by co-evolution with pathogens, host immunity continuously adapts to optimize defence against pathogens within a given environment. Recent advances in genetics, genomics and transcriptomics have enabled a more detailed investigation into how immunogenetic variation shapes the diversity of immune responses seen across domestic and wild animal species. However, a deeper understanding of the diverse molecular mechanisms that shape immunity within and among species is still needed to gain insight into-and generate evolutionary hypotheses on-the ultimate drivers of immunological differences. Here, we discuss current advances in our understanding of molecular evolution underpinning jawed vertebrate immunity. First, we introduce the immunome concept, a framework for characterizing genes involved in immune defence from a comparative perspective, then we outline how immune genes of interest can be identified. Second, we focus on how different selection modes are observed acting across groups of immune genes and propose hypotheses to explain these differences. We then provide an overview of the approaches used so far to study the evolutionary heterogeneity of immune genes on macro and microevolutionary scales. Finally, we discuss some of the current evidence as to how specific pathogens affect the evolution of different groups of immune genes. This review results from the collective discussion on the current key challenges in evolutionary immunology conducted at the ESEB 2021 Online Satellite Symposium: Molecular evolution of the vertebrate immune system, from the lab to natural populations.
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- adaptation
- adaptive immunity
- evolutionary immunology
- genomics
- host-parasite interactions
- immunogenetics
- innate immunity
- MHC
- molecular evolution
- vertebrates
- adaptation
- adaptive immunity
- evolutionary immunology
- genomics
- host-parasite interactions
- immunogenetics
- innate immunity
- MHC
- molecular evolution
- vertebrates
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Vinkler, Michal
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Fiddaman, Steven ...
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Tesický, Martin
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O'Connor, Emily ...
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Savage, Anna E.
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Lenz, Tobias L.
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visa fler...
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Smith, Adrian L.
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Kaufman, Jim
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Bolnick, Daniel ...
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Davies, Charli S ...
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Dedic, Neira
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Flies, Andrew S.
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Gomez Samblas, M ...
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Henschen, Amberl ...
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Novák, Karel
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Palomar, Gemma
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Raven, Nynke
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Samaké, Kalifa
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Slade, Joel
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Kuttiyarthu Veet ...
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Voukali, Eleni
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Höglund, Jacob
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Richardson, Davi ...
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Westerdahl, Hele ...
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Evolutionsbiolog ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Immunologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Immunologi inom ...
- Artiklar i publikationen
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Journal of Evolu ...
- Av lärosätet
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Uppsala universitet
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Lunds universitet