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Importance of CD23 ...
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Kleinau, SandraUppsala universitet,Institutionen för genetik och patologi
(författare)
Importance of CD23 for collagen-induced arthritis : delayed onset and reduced severity in CD23-deficient mice
- Artikel/kapitelEngelska1999
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-51365
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-51365URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Increased expression of the low affinity receptor for IgE, FcepsilonRII/CD23 has been observed in rheumatoid arthritis. In view of this, we have investigated the expression and influence of CD23 in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. CD23+ cells were analyzed in lymph nodes of DBA/1 mice immunized with bovine collagen type II (BCII) in CFA or with CFA only. The percentage of CD23+ lymph node cells was increased in both BCII/CFA- and CFA-immunized mice at 1, 3, and 7 wk after immunization compared with unimmunized mice, indicating a role for the adjuvant to trigger general inflammation and CD23 expression. To investigate the functional role of CD23 in CIA, CD23-deficient mice on the DBA/1 genetic background were studied. After immunization with BCII/CFA, these mice developed CIA with delayed onset and reduced severity compared with wild-type mice. These findings suggest that an increased number of CD23+ cells is part of an inflammatory response and that CD23 expression is of pathogenic importance in the arthritic process.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Martinsson, PernillaUppsala universitet,Hematologi och immunologi
(författare)
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Gustavsson, Susanne
(författare)
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Heyman, BirgittaUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)birgheym
(författare)
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Uppsala universitetInstitutionen för genetik och patologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Immunology162:7, s. 4266-42700022-17671550-6606
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