Importance of CD23 for collagen-induced arthritis: delayed onset and reduced severity in CD23-deficient mice

Kleinau, SandraUppsala universitet,Institutionen för genetik och patologi (författare)

Importance of CD23 for collagen-induced arthritis : delayed onset and reduced severity in CD23-deficient mice

Increased expression of the low affinity receptor for IgE, FcepsilonRII/CD23 has been observed in rheumatoid arthritis. In view of this, we have investigated the expression and influence of CD23 in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. CD23+ cells were analyzed in lymph nodes of DBA/1 mice immunized with bovine collagen type II (BCII) in CFA or with CFA only. The percentage of CD23+ lymph node cells was increased in both BCII/CFA- and CFA-immunized mice at 1, 3, and 7 wk after immunization compared with unimmunized mice, indicating a role for the adjuvant to trigger general inflammation and CD23 expression. To investigate the functional role of CD23 in CIA, CD23-deficient mice on the DBA/1 genetic background were studied. After immunization with BCII/CFA, these mice developed CIA with delayed onset and reduced severity compared with wild-type mice. These findings suggest that an increased number of CD23+ cells is part of an inflammatory response and that CD23 expression is of pathogenic importance in the arthritic process.

Martinsson, PernillaUppsala universitet,Hematologi och immunologi (författare)
Gustavsson, Susanne (författare)
Heyman, BirgittaUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)birgheym (författare)
Uppsala universitetInstitutionen för genetik och patologi (creator_code:org_t)

Av författaren/redakt...: Kleinau, Sandra; Martinsson, Pern ...; Gustavsson, Susa ...; Heyman, Birgitta

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