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Immunogenicity and ...
Immunogenicity and Cross-Protective Efficacy Induced by an Inactivated Recombinant Avian Influenza A/H5N1 (Clade 2.3.4.4b) Vaccine against Co-Circulating Influenza A/H5Nx Viruses
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- Mahmoud, Sara H. (author)
- Natl Res Ctr, Ctr Sci Excellence Influenza Viruses, Giza 12622, Egypt.
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- Khalil, Ahmed A. (author)
- Agr Res Ctr ARC, Vet Serum & Vaccine Res Inst, Cairo 11381, Egypt.
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- Abo Shama, Noura M. (author)
- Natl Res Ctr, Ctr Sci Excellence Influenza Viruses, Giza 12622, Egypt.
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- El Sayed, Marwa F. (author)
- Agr Res Ctr ARC, Cent Lab Evaluat Vet Biol, Cairo 11517, Egypt.
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- Soliman, Reem A. (author)
- Agr Res Ctr ARC, Cent Lab Evaluat Vet Biol, Cairo 11517, Egypt.
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- Hagag, Naglaa M. (author)
- Agr Res Ctr, Anim Hlth Res Inst, Reference Lab Vet Qual Control Poultry Prod, Giza 12618, Egypt.
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- Yehia, Nahed (author)
- Agr Res Ctr, Anim Hlth Res Inst, Reference Lab Vet Qual Control Poultry Prod, Giza 12618, Egypt.
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- Naguib, Mahmoud (author)
- Uppsala universitet,Infektionsmedicin,Institutionen för medicinsk biokemi och mikrobiologi,Agr Res Ctr, Anim Hlth Res Inst, Reference Lab Vet Qual Control Poultry Prod, Giza 12618, Egypt.
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- Arafa, Abdel-Sattar (author)
- Agr Res Ctr, Anim Hlth Res Inst, Reference Lab Vet Qual Control Poultry Prod, Giza 12618, Egypt.
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- Ali, Mohamed A. (author)
- Natl Res Ctr, Ctr Sci Excellence Influenza Viruses, Giza 12622, Egypt.
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- El-Safty, Mounir M. (author)
- Agr Res Ctr ARC, Cent Lab Evaluat Vet Biol, Cairo 11517, Egypt.
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- Mostafa, Ahmed (author)
- Natl Res Ctr, Ctr Sci Excellence Influenza Viruses, Giza 12622, Egypt.;Texas Biomed Res Inst, San Antonio, TX 78227 USA.
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Natl Res Ctr, Ctr Sci Excellence Influenza Viruses, Giza 12622, Egypt Agr Res Ctr ARC, Vet Serum & Vaccine Res Inst, Cairo 11381, Egypt. (creator_code:org_t)
- MDPI, 2023
- 2023
- English.
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In: Vaccines. - : MDPI. - 2076-393X. ; 11:9
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https://uu.diva-port... (primary) (Raw object)
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Abstract
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- Controlling avian influenza viruses (AIVs) is mainly based on culling of the infected bird flocks or via the implementation of inactivated vaccines in countries where AIVs are considered to be endemic. Over the last decade, several avian influenza virus subtypes, including highly pathogenic avian influenza (HPAI) H5N1 clade 2.2.1.2, H5N8 clade 2.3.4.4b and the recent H5N1 clade 2.3.4.4b, have been reported among poultry populations in Egypt. This demanded the utilization of a nationwide routine vaccination program in the poultry sector. Antigenic differences between available avian influenza vaccines and the currently circulating H5Nx strains were reported, calling for an updated vaccine for homogenous strains. In this study, three H5Nx vaccines were generated by utilizing the reverse genetic system: rgH5N1_2.3.4.4, rgH5N8_2.3.4.4 and rgH5N1_2.2.1.2. Further, the immunogenicity and the cross-reactivity of the generated inactivated vaccines were assessed in the chicken model against a panel of homologous and heterologous H5Nx HPAIVs. Interestingly, the rgH5N1_2.3.4.4 induced high immunogenicity in specific-pathogen-free (SPF) chicken and could efficiently protect immunized chickens against challenge infection with HPAIV H5N1_2.3.4.4, H5N8_2.3.4.4 and H5N1_2.2.1.2. In parallel, the rgH5N1_2.2.1.2 could partially protect SPF chickens against infection with HPAIV H5N1_2.3.4.4 and H5N8_2.3.4.4. Conversely, the raised antibodies to rgH5N1_2.3.4.4 could provide full protection against HPAIV H5N1_2.3.4.4 and HPAIV H5N8_2.3.4.4, and partial protection (60%) against HPAIV H5N1_2.2.1.2. Compared to rgH5N8_2.3.4.4 and rgH5N1_2.2.1.2 vaccines, chickens vaccinated with rgH5N1_2.3.4.4 showed lower viral shedding following challenge infection with the predefined HPAIVs. These data emphasize the superior immunogenicity and cross-protective efficacy of the rgH5N1_2.3.4.4 in comparison to rgH5N8_2.3.4.4 and rgH5N1_2.2.1.2.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- highly pathogenic avian influenza
- immunogenicity
- vaccine
- clade 2.3.4.4b
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mahmoud, Sara H.
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Khalil, Ahmed A.
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Abo Shama, Noura ...
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El Sayed, Marwa ...
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Soliman, Reem A.
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Hagag, Naglaa M.
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Yehia, Nahed
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Naguib, Mahmoud
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Arafa, Abdel-Sat ...
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Ali, Mohamed A.
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El-Safty, Mounir ...
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Mostafa, Ahmed
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
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Vaccines
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Uppsala University