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Comparison of four ...
Comparison of four clinical risk scores in comatose patients after out-of-hospital cardiac arrest
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- Schmidbauer, Simon (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital
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- Rylander, Christian (author)
- Uppsala University,Uppsala universitet,Anestesiologi och intensivvård
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- Cariou, Alain (author)
- Cochin Univ Hosp, APHP, Dept Hormonol, Paris, France.;Paris Cite Univ, Med Sch, Paris, France.,Cochin Hospital,Université Paris Cité
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- Wise, Matt P. (author)
- Univ Hosp Wales, Adult Crit Care, Cardiff, Wales.,University Hospital of Wales
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- Thomas, Matthew (author)
- Univ Hosp Bristol & Weston, Dept Intens Care, Bristol, Gloucestershire, England.,University Hospitals Bristol NHS Foundation Trust
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- Keeble, Thomas R. (author)
- MSE, Essex Cardiothorac Ctr, Basildon, Essex, England.;Anglia Ruskin Sch Med, MTRC, Chelmsford, Essex, England.,Anglia Ruskin University,The Essex Cardiothoracic Centre
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- Erlinge, David (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital
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- Haenggi, Matthias (author)
- Univ Bern, Bern Univ Hosp, Dept Intens Care Med, Bern, Switzerland.,Bern University Hospital
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- Wendel-Garcia, Pedro D. (author)
- Univ Hosp Zurich, Inst Intens Care Med, Zurich, Switzerland.,University Hospital of Zurich
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- Belohlavek, Jan (author)
- Charles Univ Prague, Fac Med 1, Dept Med 2, Prague, Czech Republic.;Gen Univ Hosp Prague, Prague, Czech Republic.,General University Hospital in Prague
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- Grejs, Anders Morten (author)
- Aarhus Univ, Dept Intens Care Med, Aarhus, Denmark.;Aarhus Univ Hosp, Dept Clin Med, Aarhus, Denmark.;Aarhus Univ, Aarhus, Denmark.,Aarhus University Hospital
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- Nielsen, Niklas (author)
- Lund University,Lunds universitet
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- Friberg, Hans (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SWECRIT,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups,Helsingborg Hospital
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- Dankiewicz, Josef (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
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In: Resuscitation. - : Elsevier. - 0300-9572 .- 1873-1570. ; 191
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https://doi.org/10.1...
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Abstract
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- Background and aims: Several different scoring systems for early risk stratification after out-of-hospital cardiac arrest have been developed, but few have been validated in large datasets. The aim of the present study was to compare the well-validated Out-of-hospital Cardiac Arrest (OHCA) and Cardiac Arrest Hospital Prognosis (CAHP)-scores to the less complex MIRACLE2- and Target Temperature Management (TTM)-scores.Methods: This was a post-hoc analysis of the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial. Missing data were handled by multiple imputation. The primary outcome was discriminatory performance assessed as the area under the receiver operating characteristics-curve (AUROC), with the outcome of interest being poor functional outcome or death (modified Rankin Scale 4-6) at 6 months after OHCA.Results: Data on functional outcome at 6 months were available for 1829 cases, which constituted the study population. The pooled AUROC for the MIRACLE2-score was 0.810 (95% CI 0.790-0.828), 0.835 (95% CI 0.816-0.852) for the TTM-score, 0.820 (95% CI 0.800-0.839) for the CAHPscore and 0.770 (95% CI 0.748-0.791) for the OHCA-score. At the cut-offs needed to achieve specificities >95%, sensitivities were <40% for all four scoring systems.Conclusions: The TTM-, MIRACLE2- and CAHP-scores are all capable of providing objective risk estimates accurate enough to be used as part of a holistic patient assessment after OHCA of a suspected cardiac origin. Due to its simplicity, the MIRACLE2-score could be a practical solution for both clinical application and risk stratification within trials.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- Risk prediction
- Risk score
- Outcome prediction
- Out -of -hospital cardiac arrest
- Outcome
- Out-of-hospital cardiac arrest
- Outcome
- Outcome prediction
- Risk prediction
- Risk score
Publication and Content Type
- ref (subject category)
- art (subject category)
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Schmidbauer, Sim ...
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Rylander, Christ ...
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Cariou, Alain
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Wise, Matt P.
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Thomas, Matthew
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Keeble, Thomas R ...
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Erlinge, David
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Haenggi, Matthia ...
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Wendel-Garcia, P ...
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Belohlavek, Jan
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Grejs, Anders Mo ...
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Nielsen, Niklas
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Friberg, Hans
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Dankiewicz, Jose ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
- Articles in the publication
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Resuscitation
- By the university
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Uppsala University
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Lund University