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Prevalence of SARS-...
Prevalence of SARS-CoV-2 Omicron Sublineages and Spike Protein Mutations Conferring Resistance against Monoclonal Antibodies in a Swedish Cohort during 2022–2023
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- Haars, Jonathan (författare)
- Uppsala universitet,Klinisk mikrobiologi,Department of Medical Sciences, Section for Clinical Microbiology and Hospital Hygiene Uppsala University, Akademiska Sjukhuset Entrance 40 Floor 5, 751 85 Uppsala, Sweden
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- Palanisamy, Navaneethan (författare)
- Chester Medical School, University of Chester, Chester CH2 1BR, UK
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- Wallin, Frans (författare)
- Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Södra Grev Rosengatan, 701 85 Örebro, Sweden
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- Mölling, Paula, 1971- (författare)
- Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, 701 82 Örebro, Sweden
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- Lindh, Johan (författare)
- Uppsala universitet,Klinisk mikrobiologi,Department of Medical Sciences, Section for Clinical Microbiology and Hospital Hygiene Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden
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- Sundqvist, Martin, 1974- (författare)
- Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, 701 82 Örebro, Sweden
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- Ellström, Patrik (författare)
- Uppsala universitet,Klinisk mikrobiologi,Department of Medical Sciences, Section for Clinical Microbiology and Hospital Hygiene Uppsala University, Akademiska Sjukhuset Entrance 40 Floor 5, 751 85 Uppsala, Sweden
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- Kaden, René, 1975- (författare)
- Uppsala universitet,Klinisk mikrobiologi,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Section for Clinical Microbiology and Hospital Hygiene Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden; SciLifeLab, Clinical Genomics Uppsala, Uppsala, Sweden
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- Lennerstrand, Johan (författare)
- Uppsala universitet,Klinisk mikrobiologi,Department of Medical Sciences, Section for Clinical Microbiology and Hospital Hygiene Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden
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(creator_code:org_t)
- MDPI, 2023
- 2023
- Engelska.
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Ingår i: Microorganisms. - : MDPI. - 2076-2607. ; 11:10
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Monoclonal antibodies (mAbs) are an important treatment option for COVID-19 caused by SARS-CoV-2, especially in immunosuppressed patients. However, this treatment option can become ineffective due to mutations in the SARS-CoV-2 genome, mainly in the receptor binding domain (RBD) of the spike (S) protein. In the present study, 7950 SARS-CoV-2 positive samples from the Uppsala and Örebro regions of central Sweden, collected between March 2022 and May 2023, were whole-genome sequenced using amplicon-based sequencing methods on Oxford Nanopore GridION, Illumina MiSeq, Illumina HiSeq, or MGI DNBSEQ-G400 instruments. Pango lineages were determined and all single nucleotide polymorphism (SNP) mutations that occurred in these samples were identified. We found that the dominant sublineages changed over time, and mutations conferring resistance to currently available mAbs became common. Notable ones are R346T and K444T mutations in the RBD that confer significant resistance against tixagevimab and cilgavimab mAbs. Further, mutations conferring a high-fold resistance to bebtelovimab, such as the K444T and V445P mutations, were also observed in the samples. This study highlights that resistance mutations have over time rendered currently available mAbs ineffective against SARS-CoV-2 in most patients. Therefore, there is a need for continued surveillance of resistance mutations and the development of new mAbs that target more conserved regions of the RBD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- SARS-CoV-2
- coronavirus
- monoclonal antibodies
- resistance
- nanopore
- Sweden
- whole-genome sequencing
- receptor binding domain
- Medical Virology
- Medicinsk virologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Haars, Jonathan
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Palanisamy, Nava ...
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Wallin, Frans
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Mölling, Paula, ...
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Lindh, Johan
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Sundqvist, Marti ...
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Ellström, Patrik
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Kaden, René, 197 ...
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Lennerstrand, Jo ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Mikrobiologi ino ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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Microorganisms
- Av lärosätet
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Uppsala universitet
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Örebro universitet