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Metabolomic pattern associated with physical sequelae in patients presenting with respiratory symptoms validates the aestivation concept in dehydrated patients

Barrueta Tenhunen, Annelie (författare)
Uppsala universitet,Anestesiologi och intensivvård
Butler-Laporte, Guillaume (författare)
McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.;McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ, Canada.
Yoshiji, Satoshi (författare)
McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Program Genom Med, Kyoto, Japan.;Japan Soc Promot Sci, Tokyo, Japan.
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Morrison, Dave R. (författare)
Uppsala universitet,Hedenstiernalaboratoriet,McGill Univ, Dept Human Genet, Montreal, PQ, Canada.
Nakanishi, Tomoko (författare)
McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Program Genom Med, Kyoto, Japan.;Japan Soc Promot Sci, Tokyo, Japan.
Chen, Yiheng (författare)
McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.
Forgetta, Vincenzo (författare)
McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;5 Prime Sci, Montreal, PQ, Canada.
Farjoun, Yossi (författare)
McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ, Canada.;5 Prime Sci, Montreal, PQ, Canada.;Broad Inst Harvard & MIT, Cambridge, MA USA.;Fulcrum Genom, Boulder, CO USA.
Marton, Adriana (författare)
Duke NUS Med Sch, Program Cardiovasc & Metab Disorders, Singapore, Singapore.
Titze, Jens Marc (författare)
Duke NUS Med Sch, Program Cardiovasc & Metab Disorders, Singapore, Singapore.;Duke Univ, Med Ctr, Div Nephrol, Durham, NC USA.
Nihlén, Sandra (författare)
Uppsala universitet,Anestesiologi och intensivvård
Frithiof, Robert (författare)
Uppsala universitet,Anestesiologi och intensivvård
Lipcsey, Miklós (författare)
Uppsala universitet,Hedenstiernalaboratoriet
Richards, J. Brent (författare)
McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.;McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Kings Coll London, Dept Twin Res, London, England.;5 Prime Sci, Montreal, PQ, Canada.
Hultström, Michael, 1978- (författare)
Uppsala universitet,Anestesiologi och intensivvård,McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.;McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ, Canada.;Uppsala Univ, Dept Med Cell Biol, Integrat Physiol, Uppsala, Sweden.
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 (creator_code:org_t)
American Physiological Society, 2024
2024
Engelska.
Ingår i: Physiological Genomics. - : American Physiological Society. - 1094-8341 .- 1531-2267. ; 56:7, s. 483-491
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Hypertonic dehydration is associated with muscle wasting and synthesis of organic osmolytes. We recently showed a metabolic shift to amino acid production and urea cycle activation in coronavirus-2019 (COVID-19), consistent with the aestivation response. The aim of the present investigation was to validate the metabolic shift and development of long-term physical outcomes in the non-COVID cohort of the Biobanque Qu & eacute;b & eacute;coise de la COVID-19 (BQC19). We included 824 patients from BQC19, where 571 patients had data of dehydration in the form of estimated osmolality (eOSM = 2Na + 2K + glucose + urea), and 284 patients had metabolome data and long-term follow-up. We correlated the degree of dehydration to mortality, invasive mechanical ventilation, acute kidney injury, and long-term symptoms. As found in the COVID cohort, higher eOSM correlated with a higher proportion of urea and glucose of total eOSM, and an enrichment of amino acids compared with other metabolites. Sex-stratified analysis indicated that women may show a weaker aestivation response. More severe dehydration was associated with mortality, invasive mechanical ventilation, and acute kidney injury during the acute illness. Importantly, more severe dehydration was associated with physical long-term symptoms but not mental long-term symptoms after adjustment for age, sex, and disease severity. Patients with water deficit in the form of increased eOSM tend to have more severe disease and experience more physical symptoms after an acute episode of care. This is associated with amino acid and urea production, indicating dehydration-induced muscle wasting.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)

Nyckelord

aestivation
long-term symptoms
muscle wasting
sex differences
urea synthesis

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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