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Reference standards...
Reference standards for follicular density in ovarian cortex from birth to sexual maturity
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- Hassan, Jasmin (författare)
- Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Obstet & Gynaecol, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Gynaecol & Reprod Med, Stockholm, Sweden.
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- Knuus, Katri (författare)
- Karolinska Institutet
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- Lahtinen, Atte (författare)
- Univ Helsinki, Fac Med, Appl Tumor Genom Res Program, Helsinki, Finland.;Univ Helsinki, Fac Med, Dept Med & Clin Genet Medicum, Helsinki, Finland.
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- Rooda, Ilmatar (författare)
- Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Obstet & Gynaecol, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Gynaecol & Reprod Med, Stockholm, Sweden.
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- Otala, Marjut (författare)
- Univ Helsinki, Dept Ophthalmol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
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- Tuuri, Timo (författare)
- Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynaecol, Helsinki, Finland.
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- Gidlöf, Sebastian (författare)
- Karolinska Institutet
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- Edlund, Erik (författare)
- Karolinska Univ Hosp, Dept Gynaecol & Reprod Med, Stockholm, Sweden.
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- Menezes, Judith (författare)
- Karolinska Univ Hosp, Dept Gynaecol & Reprod Med, Stockholm, Sweden.
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- Malmros, Johan (författare)
- Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden.
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- Byström, Petra (författare)
- Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Paediat, Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Sect Haematol Immunol & HCT, Stockholm, Sweden.
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- Sundin, Mikael (författare)
- Karolinska Institutet
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- Langenskiöld, Cecilia (författare)
- Sahlgrens Univ Hosp, Queen Silvia Childrens Hosp, Dept Paediat Oncol, Gothenburg, Sweden.;Karolinska Inst, Dept Womens & Childrens Hlth, NORDFERTIL Res Lab Stockholm, Stockholm, Sweden.
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- Vogt, Hartmut (författare)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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- Frisk, Per, 1966- (författare)
- Uppsala universitet,Barnonkologisk forskning - särskilt fokus på komplikationer,Uppsala Univ, Sweden
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- Petersen, Cecilia (författare)
- Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Paediat Oncol, Stockholm, Sweden.
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- Damdimopoulou, Pauliina (författare)
- Karolinska Institutet
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- Jahnukainen, Kirsi (författare)
- Karolinska Inst, Dept Womens & Childrens Hlth, NORDFERTIL Res Lab Stockholm, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.;Univ Helsinki, Childrens Hosp, Paediat Res Ctr, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
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Karolinska Institutet Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Obstet & Gynaecol, Stockholm, Sweden;Karolinska Univ Hosp, Dept Gynaecol & Reprod Med, Stockholm, Sweden. (creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Reproductive BioMedicine Online. - : Elsevier. - 1472-6483 .- 1472-6491. ; 47:4
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Research question: Are age-normalized reference values for human ovarian cortical follicular density adequate for tissue quality control in fertility preservation?Design: Published quantitative data on the number of follicles in samples without known ovarian pathology were converted into cortical densities to create reference values. Next, a sample cohort of 126 girls (age 1-24 years, mean +/- SD 11 +/- 6) with cancer, severe haematological disease or Turner syndrome were used to calculate Z-scores for cortical follicular density based on the reference values.Results: No difference was observed between Z-scores in samples from untreated patients (0.3 +/- 3.5, n = 30) and patients treated with (0.5 +/- 2.9, n = 48) and without (0.1 +/- 1.3, n = 6) alkylating chemotherapy. Z-scores were not correlated with increasing cumulative exposure to cytostatics. Nevertheless, Z-scores in young treated patients (0-2 years -2.1 +/- 3.1, n = 10, P = 0.04) were significantly lower than Z-scores in older treated patients (11-19 years, 2 +/- 1.9, n = 15). Samples from patients with Turner syndrome differed significantly from samples from untreated patients (-5.2 +/- 5.1, n = 24, P = 0.003), and a Z-score of -1.7 was identified as a cut-off showing good diagnostic value for identification of patients with Turner syndrome with reduced ovarian reserve. When this cut-off was applied to other patients, analysis showed that those with indications for reduced ovarian reserve (n = 15) were significantly younger (5.9 +/- 4.2 versus 10.7 +/- 5.9 years, P = 0.004) and, when untreated, more often had non-malignant haematologic diseases compared with those with normal ovarian reserve (n = 24, 100% versus 19%, P = 0.009).Conclusion: Z-scores allow the estimation of genetic- and treatment-related effects on follicular density in cortical tissue from young patients stored for fertility preservation. Understanding the quality of cryopreserved tissue facilitates its use during patient counselling. More research is needed regarding the cytostatic effects found in this study.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Child
- Follicular density
- Female fertility preservation
- Ovarian tissue cryopreservation
- Young adult
- Z-score
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hassan, Jasmin
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Knuus, Katri
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Lahtinen, Atte
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Rooda, Ilmatar
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Otala, Marjut
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Tuuri, Timo
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visa fler...
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Gidlöf, Sebastia ...
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Edlund, Erik
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Menezes, Judith
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Malmros, Johan
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Byström, Petra
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Sundin, Mikael
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Langenskiöld, Ce ...
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Vogt, Hartmut
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Frisk, Per, 1966 ...
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Petersen, Cecili ...
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Damdimopoulou, P ...
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Jahnukainen, Kir ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Reproduktionsmed ...
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Reproductive Bio ...
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Uppsala universitet
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Linköpings universitet
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Karolinska Institutet