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  • Barth, ClaudiaDiakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway. (författare)

In vivo white matter microstructure in adolescents with early-onset psychosis : a multi-site mega-analysis

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2022-12-12
  • Springer Nature,2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-515049
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-515049URI
  • https://doi.org/10.1038/s41380-022-01901-3DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:153908691URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 years). However, as neuroimaging methods vary and sample sizes are modest, results remain inconclusive. Using harmonized data processing protocols and a mega-analytic approach, we compared white matter microstructure in EOP and healthy controls using diffusion tensor imaging (DTI). Our sample included 321 adolescents with EOP (median age=16.6 years, interquartile range (IQR)=2.14, 46.4% females) and 265 adolescent healthy controls (median age=16.2 years, IQR=2.43, 57.7% females) pooled from nine sites. All sites extracted mean fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) for 25 white matter regions of interest per participant. ComBat harmonization was performed for all DTI measures to adjust for scanner differences. Multiple linear regression models were fitted to investigate case-control differences and associations with clinical variables in regional DTI measures. We found widespread lower FA in EOP compared to healthy controls, with the largest effect sizes in the superior longitudinal fasciculus (Cohen's d=0.37), posterior corona radiata (d=0.32), and superior fronto-occipital fasciculus (d=0.31). We also found widespread higher RD and more localized higher MD and AD. We detected significant effects of diagnostic subgroup, sex, and duration of illness, but not medication status. Using the largest EOP DTI sample to date, our findings suggest a profile of widespread white matter microstructure alterations in adolescents with EOP, most prominently in male individuals with early-onset schizophrenia and individuals with a shorter duration of illness.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Kelly, SineadKings Coll London, Dept Psychosis Studies, London, England. (författare)
  • Nerland, StenerDiakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway. (författare)
  • Jahanshad, NedaUniv Southern Calif, Mark Mary Stevens Neuroimaging Informat Inst, Keck Sch Med, Imaging Genet Ctr, Marina Del Rey, CA USA. (författare)
  • Alloza, ClaraHosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, IiSGM, Madrid, Spain. (författare)
  • Ambrogi, SoniaSanta Lucia Fdn IRCCS, Lab Neuropsychiat, Rome, Italy. (författare)
  • Andreassen, Ole A.Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.;Oslo Univ Hosp, Div Mental Hlth & Addict, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway. (författare)
  • Andreou, DimitriosKarolinska Institutet (författare)
  • Arango, CelsoHosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, IiSGM, Madrid, Spain.;Univ Complutense, Sch Med, Madrid, Spain. (författare)
  • Baeza, InmaculadaUniv Barcelona, August Pi Sunyer Biomed Res Inst IDIBAPS, Dept Child & Adolescent Psychiat & Psychol, Inst Neurosci, 2017SGR881, Barcelona, Spain. (författare)
  • Banaj, NerisaSanta Lucia Fdn IRCCS, Lab Neuropsychiat, Rome, Italy. (författare)
  • Bearden, Carrie E.UCLA, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA.;UCLA, Dept Psychol, Los Angeles, CA USA. (författare)
  • Berk, MichaelDeakin Univ, Inst Mental & Phys Hlth & Clin Translat, Sch Med, Barwon Hlth, Geelong, Vic, Australia. (författare)
  • Bohman, Hannes,1965-Uppsala universitet,Barn- och ungdomspsykiatri,Karolinska Inst, Dept Clin Sci & Educ Sodersjukhuset, Stockholm, Sweden.(Swepub:uu)hanbo757 (författare)
  • Castro-Fornieles, JosefinaUniv Barcelona, August Pi Sunyer Biomed Res Inst IDIBAPS, Dept Child & Adolescent Psychiat & Psychol, Inst Neurosci, 2017SGR881, Barcelona, Spain. (författare)
  • Chye, YannMonash Univ, Turner Inst Brain & Mental Hlth & Sch Psychol Sci, Melbourne, Vic, Australia. (författare)
  • Crespo-Facorro, BenedictoUniv Seville, Hosp Univ Virgen Rocio, Dept Psychiat, CIBERSAM, Seville, Spain. (författare)
  • de la Serna, ElenaUniv Barcelona, August Pi Sunyer Biomed Res Inst IDIBAPS, Dept Child & Adolescent Psychiat & Psychol, Inst Neurosci, 2017SGR881, Barcelona, Spain. (författare)
  • Diaz-Caneja, Covadonga M.Hosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, IiSGM, Madrid, Spain.;Univ Complutense, Sch Med, Madrid, Spain. (författare)
  • Gurholt, Tiril P.Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.;Oslo Univ Hosp, Div Mental Hlth & Addict, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway. (författare)
  • Hegarty, Catherine E.UCLA, Dept Psychol, Los Angeles, CA USA. (författare)
  • James, AnthonyWarneford Hosp, Highfield Unit, Oxford, England.;Warneford Hosp, Highfield Unit, Oxford, England. (författare)
  • Janssen, JoostHosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, IiSGM, Madrid, Spain. (författare)
  • Johannessen, CecilieUniv Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway. (författare)
  • Jönsson, Erik G.Karolinska Institutet (författare)
  • Karlsgodt, Katherine H.UCLA, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA.;UCLA, Dept Psychol, Los Angeles, CA USA. (författare)
  • Kochunov, PeterUniv Oxford, Dept Psychiat, Oxford, England. (författare)
  • Lois, Noemi G.Univ Maryland, Dept Psychiat, Maryland Psychiat Res Ctr, Sch Med, Baltimore, MA USA. (författare)
  • Lundberg, MathiasUppsala universitet,Barn- och ungdomspsykiatri,Karolinska Inst, Dept Clin Sci & Educ Sodersjukhuset, Stockholm, Sweden.(Swepub:uu)matlu897 (författare)
  • Myhre, Anne M.Oslo Univ Hosp, Div Mental Hlth & Addict, Sect Child & Adolescent Mental Hlth Res, Oslo, Norway. (författare)
  • Pascual-Diaz, SauelUniv Barcelona, August Pi Sunyer Biomed Res Inst IDIBAPS, Magnet Resonance Imaging Core Facil, Barcelona, Spain. (författare)
  • Piras, FabrizioSanta Lucia Fdn IRCCS, Lab Neuropsychiat, Rome, Italy. (författare)
  • Smelror, Runar E.Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway. (författare)
  • Spalletta, GianfrancoSanta Lucia Fdn IRCCS, Lab Neuropsychiat, Rome, Italy.;Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX USA. (författare)
  • Stokkan, Therese S.Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway. (författare)
  • Sugranyes, GiselaUniv Barcelona, August Pi Sunyer Biomed Res Inst IDIBAPS, Dept Child & Adolescent Psychiat & Psychol, Inst Neurosci, 2017SGR881, Barcelona, Spain. (författare)
  • Suo, ChaoMonash Univ, Turner Inst Brain & Mental Hlth & Sch Psychol Sci, Melbourne, Vic, Australia. (författare)
  • Thomopoulos, Sophia I.Univ Southern Calif, Mark Mary Stevens Neuroimaging Informat Inst, Keck Sch Med, Imaging Genet Ctr, Marina Del Rey, CA USA. (författare)
  • Tordesillas-Gutierrez, DianaMarques Valdecilla Univ Hosp, Valdecilla Biomed Res Inst IDIVAL, Dept Radiol, Santander, Spain.;Inst Fis Cantabria UC CSIC, Advanced Comp & Sci, Santander, Spain. (författare)
  • Vecchio, DanielaSanta Lucia Fdn IRCCS, Lab Neuropsychiat, Rome, Italy. (författare)
  • Wedervang-Resell, KirstenOslo Univ Hosp, Div Mental Hlth & Addict, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway. (författare)
  • Wortinger, Laura A.Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway. (författare)
  • Thompson, Paul M.Univ Southern Calif, Mark Mary Stevens Neuroimaging Informat Inst, Keck Sch Med, Imaging Genet Ctr, Marina Del Rey, CA USA. (författare)
  • Agartz, IngridDiakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.;Karolinska Inst Stockholm Hlth Care Serv, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden. (författare)
  • Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.Kings Coll London, Dept Psychosis Studies, London, England. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Molecular Psychiatry: Springer Nature28, s. 1159-11691359-41841476-5578

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