Search: WFRF:(Bohman Hannes)
> (2020-2023) >
In vivo white matte...
In vivo white matter microstructure in adolescents with early-onset psychosis : a multi-site mega-analysis
-
- Barth, Claudia (author)
- Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.
-
- Kelly, Sinead (author)
- Kings Coll London, Dept Psychosis Studies, London, England.
-
- Nerland, Stener (author)
- Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.
-
show more...
-
- Jahanshad, Neda (author)
- Univ Southern Calif, Mark Mary Stevens Neuroimaging Informat Inst, Keck Sch Med, Imaging Genet Ctr, Marina Del Rey, CA USA.
-
- Alloza, Clara (author)
- Hosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, IiSGM, Madrid, Spain.
-
- Ambrogi, Sonia (author)
- Santa Lucia Fdn IRCCS, Lab Neuropsychiat, Rome, Italy.
-
- Andreassen, Ole A. (author)
- Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.;Oslo Univ Hosp, Div Mental Hlth & Addict, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.
-
- Andreou, Dimitrios (author)
- Karolinska Institutet
-
- Arango, Celso (author)
- Hosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, IiSGM, Madrid, Spain.;Univ Complutense, Sch Med, Madrid, Spain.
-
- Baeza, Inmaculada (author)
- Univ Barcelona, August Pi Sunyer Biomed Res Inst IDIBAPS, Dept Child & Adolescent Psychiat & Psychol, Inst Neurosci, 2017SGR881, Barcelona, Spain.
-
- Banaj, Nerisa (author)
- Santa Lucia Fdn IRCCS, Lab Neuropsychiat, Rome, Italy.
-
- Bearden, Carrie E. (author)
- UCLA, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA.;UCLA, Dept Psychol, Los Angeles, CA USA.
-
- Berk, Michael (author)
- Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Sch Med, Barwon Hlth, Geelong, Vic, Australia.
-
- Bohman, Hannes, 1965- (author)
- Uppsala universitet,Barn- och ungdomspsykiatri,Karolinska Inst, Dept Clin Sci & Educ Sodersjukhuset, Stockholm, Sweden.
-
- Castro-Fornieles, Josefina (author)
- Univ Barcelona, August Pi Sunyer Biomed Res Inst IDIBAPS, Dept Child & Adolescent Psychiat & Psychol, Inst Neurosci, 2017SGR881, Barcelona, Spain.
-
- Chye, Yann (author)
- Monash Univ, Turner Inst Brain & Mental Hlth & Sch Psychol Sci, Melbourne, Vic, Australia.
-
- Crespo-Facorro, Benedicto (author)
- Univ Seville, Hosp Univ Virgen Rocio, Dept Psychiat, CIBERSAM, Seville, Spain.
-
- de la Serna, Elena (author)
- Univ Barcelona, August Pi Sunyer Biomed Res Inst IDIBAPS, Dept Child & Adolescent Psychiat & Psychol, Inst Neurosci, 2017SGR881, Barcelona, Spain.
-
- Diaz-Caneja, Covadonga M. (author)
- Hosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, IiSGM, Madrid, Spain.;Univ Complutense, Sch Med, Madrid, Spain.
-
- Gurholt, Tiril P. (author)
- Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.;Oslo Univ Hosp, Div Mental Hlth & Addict, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.
-
- Hegarty, Catherine E. (author)
- UCLA, Dept Psychol, Los Angeles, CA USA.
-
- James, Anthony (author)
- Warneford Hosp, Highfield Unit, Oxford, England.;Warneford Hosp, Highfield Unit, Oxford, England.
-
- Janssen, Joost (author)
- Hosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, IiSGM, Madrid, Spain.
-
- Johannessen, Cecilie (author)
- Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.
-
- Jönsson, Erik G. (author)
- Karolinska Institutet
-
- Karlsgodt, Katherine H. (author)
- UCLA, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA.;UCLA, Dept Psychol, Los Angeles, CA USA.
-
- Kochunov, Peter (author)
- Univ Oxford, Dept Psychiat, Oxford, England.
-
- Lois, Noemi G. (author)
- Univ Maryland, Dept Psychiat, Maryland Psychiat Res Ctr, Sch Med, Baltimore, MA USA.
-
- Lundberg, Mathias (author)
- Uppsala universitet,Barn- och ungdomspsykiatri,Karolinska Inst, Dept Clin Sci & Educ Sodersjukhuset, Stockholm, Sweden.
-
- Myhre, Anne M. (author)
- Oslo Univ Hosp, Div Mental Hlth & Addict, Sect Child & Adolescent Mental Hlth Res, Oslo, Norway.
-
- Pascual-Diaz, Sauel (author)
- Univ Barcelona, August Pi Sunyer Biomed Res Inst IDIBAPS, Magnet Resonance Imaging Core Facil, Barcelona, Spain.
-
- Piras, Fabrizio (author)
- Santa Lucia Fdn IRCCS, Lab Neuropsychiat, Rome, Italy.
-
- Smelror, Runar E. (author)
- Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.
-
- Spalletta, Gianfranco (author)
- Santa Lucia Fdn IRCCS, Lab Neuropsychiat, Rome, Italy.;Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX USA.
-
- Stokkan, Therese S. (author)
- Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.
-
- Sugranyes, Gisela (author)
- Univ Barcelona, August Pi Sunyer Biomed Res Inst IDIBAPS, Dept Child & Adolescent Psychiat & Psychol, Inst Neurosci, 2017SGR881, Barcelona, Spain.
-
- Suo, Chao (author)
- Monash Univ, Turner Inst Brain & Mental Hlth & Sch Psychol Sci, Melbourne, Vic, Australia.
-
- Thomopoulos, Sophia I. (author)
- Univ Southern Calif, Mark Mary Stevens Neuroimaging Informat Inst, Keck Sch Med, Imaging Genet Ctr, Marina Del Rey, CA USA.
-
- Tordesillas-Gutierrez, Diana (author)
- Marques Valdecilla Univ Hosp, Valdecilla Biomed Res Inst IDIVAL, Dept Radiol, Santander, Spain.;Inst Fis Cantabria UC CSIC, Advanced Comp & Sci, Santander, Spain.
-
- Vecchio, Daniela (author)
- Santa Lucia Fdn IRCCS, Lab Neuropsychiat, Rome, Italy.
-
- Wedervang-Resell, Kirsten (author)
- Oslo Univ Hosp, Div Mental Hlth & Addict, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.
-
- Wortinger, Laura A. (author)
- Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.
-
- Thompson, Paul M. (author)
- Univ Southern Calif, Mark Mary Stevens Neuroimaging Informat Inst, Keck Sch Med, Imaging Genet Ctr, Marina Del Rey, CA USA.
-
- Agartz, Ingrid (author)
- Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway.;Karolinska Inst Stockholm Hlth Care Serv, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.
-
show less...
-
Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway;Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway. Kings Coll London, Dept Psychosis Studies, London, England. (creator_code:org_t)
- 2022-12-12
- 2023
- English.
-
In: Molecular Psychiatry. - : Springer Nature. - 1359-4184 .- 1476-5578. ; 28, s. 1159-1169
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 years). However, as neuroimaging methods vary and sample sizes are modest, results remain inconclusive. Using harmonized data processing protocols and a mega-analytic approach, we compared white matter microstructure in EOP and healthy controls using diffusion tensor imaging (DTI). Our sample included 321 adolescents with EOP (median age=16.6 years, interquartile range (IQR)=2.14, 46.4% females) and 265 adolescent healthy controls (median age=16.2 years, IQR=2.43, 57.7% females) pooled from nine sites. All sites extracted mean fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) for 25 white matter regions of interest per participant. ComBat harmonization was performed for all DTI measures to adjust for scanner differences. Multiple linear regression models were fitted to investigate case-control differences and associations with clinical variables in regional DTI measures. We found widespread lower FA in EOP compared to healthy controls, with the largest effect sizes in the superior longitudinal fasciculus (Cohen's d=0.37), posterior corona radiata (d=0.32), and superior fronto-occipital fasciculus (d=0.31). We also found widespread higher RD and more localized higher MD and AD. We detected significant effects of diagnostic subgroup, sex, and duration of illness, but not medication status. Using the largest EOP DTI sample to date, our findings suggest a profile of widespread white matter microstructure alterations in adolescents with EOP, most prominently in male individuals with early-onset schizophrenia and individuals with a shorter duration of illness.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Barth, Claudia
-
Kelly, Sinead
-
Nerland, Stener
-
Jahanshad, Neda
-
Alloza, Clara
-
Ambrogi, Sonia
-
show more...
-
Andreassen, Ole ...
-
Andreou, Dimitri ...
-
Arango, Celso
-
Baeza, Inmaculad ...
-
Banaj, Nerisa
-
Bearden, Carrie ...
-
Berk, Michael
-
Bohman, Hannes, ...
-
Castro-Fornieles ...
-
Chye, Yann
-
Crespo-Facorro, ...
-
de la Serna, Ele ...
-
Diaz-Caneja, Cov ...
-
Gurholt, Tiril P ...
-
Hegarty, Catheri ...
-
James, Anthony
-
Janssen, Joost
-
Johannessen, Cec ...
-
Jönsson, Erik G.
-
Karlsgodt, Kathe ...
-
Kochunov, Peter
-
Lois, Noemi G.
-
Lundberg, Mathia ...
-
Myhre, Anne M.
-
Pascual-Diaz, Sa ...
-
Piras, Fabrizio
-
Smelror, Runar E ...
-
Spalletta, Gianf ...
-
Stokkan, Therese ...
-
Sugranyes, Gisel ...
-
Suo, Chao
-
Thomopoulos, Sop ...
-
Tordesillas-Guti ...
-
Vecchio, Daniela
-
Wedervang-Resell ...
-
Wortinger, Laura ...
-
Thompson, Paul M ...
-
Agartz, Ingrid
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Psychiatry
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Radiology Nuclea ...
- Articles in the publication
-
Molecular Psychi ...
- By the university
-
Uppsala University
-
Karolinska Institutet