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Plasma proteins and...
Plasma proteins and onset of type 2 diabetes and diabetic complications : Proteome-wide Mendelian randomization and colocalization analyses
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- Yuan, Shuai (författare)
- Karolinska Institutet
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- Xu, Fengzhe (författare)
- Westlake Univ, Sch Life Sci, Key Lab Growth Regulat & Translat Res Zhejiang Pro, Hangzhou, Peoples R China.
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- Li, Xue (författare)
- Zhejiang Univ, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci,Sch Publ Hlth,Sch Med, Hangzhou, Peoples R China.
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- Chen, Jie (författare)
- Zhejiang Univ, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci,Sch Publ Hlth,Sch Med, Hangzhou, Peoples R China.;Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Endocrine & Metab Dis, Ruijin Hosp,Dept Endocrine & Metab Dis, Shanghai, Peoples R China.
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- Zheng, Jie (författare)
- Shanghai Jiao Tong Univ, Shanghai Natl Ctr Translat Med, Key Lab Endocrine & Metab Dis, Shanghai Natl Clin Res Ctr Metab Dis,Shanghai Key, Shanghai 200025, Peoples R China.
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- Mantzoros, Christos S. (författare)
- Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA USA.;Harvard Med Sch, Sect Endocrinol, VA Boston Healthcare Syst, Boston, MA 02115 USA.
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- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
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Karolinska Institutet Westlake Univ, Sch Life Sci, Key Lab Growth Regulat & Translat Res Zhejiang Pro, Hangzhou, Peoples R China (creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska.
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Ingår i: CELL REPORTS MEDICINE. - : Elsevier BV. - 2666-3791. ; 4:9
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- We conduct proteome-wide Mendelian randomization and colocalization analyses to decipher the associa-tions of blood proteins with the risk of type 2 diabetes and diabetic complications. Genetic data on plasma proteome are obtained from 54,306 UK Biobank participants and 35,559 Icelanders. Summary-level data on type 2 diabetes are obtained from the DIAGRAM (DIAbetes Genetics Replication And Meta-analysis con-sortium) consortium (74,124 cases) and FinnGen study (33,043 cases). Data on 10 diabetic complications are obtained from FinnGen and corresponding studies. Among 1,886 proteins, genetically predicted levels of 47 plasma proteins are associated with type 2 diabetes. Eleven of these proteins have strong support of colocalization. Seventeen proteins are associated with at least one diabetic complication, although a few have colocalization support. HLA-DRA, AGER, HSPA1A, and HSPA1B are associated with most microvas-cular complications. This study reveals causal proteins for the onset of type 2 diabetes and diabetic compli-cations, which enhances the understanding of molecular etiology and development of therapeutics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- colocalization
- diabetic complication
- Mendelian randomization
- plasma protein
- type 2 diabetes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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