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Positive airway pre...
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Emilsson, Össur IngiUppsala universitet,Lung- allergi- och sömnforskning,Landspitali Natl Univ Hosp Iceland, Dept Sleep, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
(författare)
Positive airway pressure treatment affects respiratory symptoms and gastro-oesophageal reflux : the Icelandic Sleep Apnea Cohort Study
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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European Respiratory Society,2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-515591
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-515591URI
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https://doi.org/10.1183/23120541.00387-2023DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Aim: To study the effect of positive airway pressure (PAP) treatment on nocturnal gastro-oesophageal reflux (nGOR) and respiratory symptoms among clinical obstructive sleep apnoea (OSA) patients.Methods: 822 patients newly diagnosed with OSA referred for PAP treatment were recruited. 732 patients had a 2-year follow-up visit with continuous PAP compliance data (366 full PAP users, 366 partial/non-PAP users). They answered questionnaires, including reporting of nGOR, sleep and respiratory symptoms and general health. Patients with nGOR symptoms once a week or more were defined as "with nGOR". Those without nGOR symptoms and nGOR medication were defined as "no nGOR". Others were defined as "possible nGOR".Results: At 2-year follow-up, PAP treatment among full users resulted in decreased nGOR (adjusted OR 0.58, 95% CI 0.40-0.86) and wheezing (adjusted OR 0.56, 95% CI 0.35-0.88) compared with partial/non-PAP users. Decreased nGOR, among both full and partial/non-users of PAP treatment, was associated with a decrease in productive morning cough (adjusted OR 4.70, 95% CI 2.22-9.99) and a decrease in chronic bronchitis (adjusted OR 3.86, 95% CI 1.74-8.58), but not decreased wheezing (adjusted OR 0.90, 95% CI 0.39-2.08). A mediation analysis found that PAP treatment directly led to a decrease in wheezing, not mediated through nGOR. Conversely, PAP treatment decreased productive cough mediated through a decrease in nGOR.Conclusion: In an unselected group of OSA patients, PAP treatment for 2 years was associated with a decrease in nGOR and respiratory symptoms. The PAP treatment itself was associated with less wheezing. A decrease in nGOR through PAP treatment was associated with a decrease in productive cough.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Aspelund, ThorUniv Iceland, Ctr Publ Hlth Sci, Reykjavik, Iceland.
(författare)
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Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn
(författare)
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Benediktsdottir, BryndisLandspitali Natl Univ Hosp Iceland, Dept Sleep, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
(författare)
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Juliusson, SigurdurLandspitali Natl Univ Hosp Iceland, Dept Otolaryngol, Reykjavik, Iceland.;Univ Penn, Div Sleep Med, Dept Med, Philadelphia, PA 19104 USA.
(författare)
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Maislin, GregUniv Penn, Div Sleep Med, Dept Med, Philadelphia, PA 19104 USA.
(författare)
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Pack, Allan I.Univ Penn, Div Sleep Med, Dept Med, Philadelphia, PA 19104 USA.
(författare)
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Keenan, Brendan T.Univ Penn, Div Sleep Med, Dept Med, Philadelphia, PA 19104 USA.
(författare)
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Gislason, ThorarinnLandspitali Natl Univ Hosp Iceland, Dept Sleep, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
(författare)
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Uppsala universitetLung- allergi- och sömnforskning
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:ERJ Open Research: European Respiratory Society9:52312-0541
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