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Plasma phospholipid...
Plasma phospholipid arachidonic acid in relation to non-alcoholic fatty liver disease : Mendelian randomization study
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- Chen, Jie (författare)
- Zhejiang Univ, Ctr Global Hlth, Sch Med, Hangzhou, Peoples R China.;Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China.
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- Ruan, Xixian (författare)
- Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China.
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- Sun, Yuhao (författare)
- Zhejiang Univ, Ctr Global Hlth, Sch Med, Hangzhou, Peoples R China.
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- Li, Xue (författare)
- Zhejiang Univ, Sch Publ Hlth, Sch Med, Hangzhou, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Peoples R China.;Univ Edinburgh, Usher Inst, Ctr Global Hlth, Edinburgh, Midlothian, Scotland.
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- Yuan, Shuai (författare)
- Karolinska Institutet
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- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
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Zhejiang Univ, Ctr Global Hlth, Sch Med, Hangzhou, Peoples R China;Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China. Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China. (creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Nutrition (Burbank, Los Angeles County, Calif.). - : Elsevier. - 0899-9007 .- 1873-1244. ; 106
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives: The role of plasma phospholipid arachidonic acid (AA) in the development of non-alcoholic fatty liver disease (NALFD), cirrhosis, and liver cancer remains unclear. This study aimed to determine the causality of the associations of plasma phospholipid AA with NALFD, cirrhosis, and liver cancer using Mendelian ran-domization analysis.Methods: Nine independent single-nucleotide polymorphisms associated with plasma phospholipid AA at the genome-wide significance were used as instrumental variables. Summary-level data for three outcomes were obtained from 1) a genome-wide association study for NAFLD, 2) the UK Biobank study, and 3) the Finn -Gen study. The sensitivity analysis excluding the pleiotropic variant rs174547 in the FADS1 gene was per-formed. Estimates from different sources were combined using the fixed-effects meta-analysis method.Results: Per standard deviation increase in AA levels, the combined odds ratio was 1.06 (95% confidence inter-val, 1.02-1.11; P = 0.008) for NAFLD, 1.05 (95% confidence interval, 1.01-1.09; P = 0.009) for cirrhosis, and 0.99 (95% confidence interval, 0.94-1.05; P = 0.765) for liver cancer. The associations remained stable in the sensitivity analysis excluding rs174547.Conclusions: This study suggests potential causal associations of high levels of plasma phospholipid AA with the risk of NAFLD and cirrhosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Arachidonic acid
- Cirrhosis
- Non-alcoholic fatty liver disease
- Mendelian randomization analysis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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