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Inflammatory relate...
Inflammatory related plasma proteins involved in acute preschool wheeze
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- Holmdahl, Idun (författare)
- Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgrens Childrens Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Womens & Childrens Hlth, KPE Barnallergiforskningen, QB 84, Karolinskavagen 37, SE-17176 Solna, Sweden.
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- Chakraborty, Sandip (författare)
- Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgrens Childrens Hosp, Stockholm, Sweden.
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- Hoyer, Angela (författare)
- Karolinska Institutet
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- Filiou, Anastasia (författare)
- Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgrens Childrens Hosp, Stockholm, Sweden.
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- Asarnoj, Anna (författare)
- Karolinska Institutet
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- Sjölander, Anders (författare)
- Thermo Fisher Sci, Uppsala, Sweden.
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- Borres, Magnus P., 1956- (författare)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Thermo Fisher Sci, Uppsala, Sweden
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- van Hage, Marianne (författare)
- Karolinska Institutet
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- Hedlin, Gunilla (författare)
- Karolinska Institutet
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- Konradsen, Jon R. (författare)
- Karolinska Institutet
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- Söderhäll, Cilla (författare)
- Karolinska Institutet
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Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden;Karolinska Univ Hosp, Astrid Lindgrens Childrens Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Womens & Childrens Hlth, KPE Barnallergiforskningen, QB 84, Karolinskavagen 37, SE-17176 Solna, Sweden. Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgrens Childrens Hosp, Stockholm, Sweden. (creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- Engelska.
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Ingår i: Clinical and Translational Allergy. - : John Wiley & Sons. - 2045-7022. ; 13:11
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BackgroundPreschool wheeze is a risk factor for asthma development. However, the molecular mechanism behind a wheezing episode is not well understood.ObjectiveOur aims were to assess the association of plasma proteins with acute preschool wheeze and to study the proteins with differential expression at the acute phase at revisit after 3 months. Additionally, to investigate the relationship between protein expression and clinical parameters.MethodWe measured 92 inflammatory proteins in plasma and clinical parameters from 145 children during an episode of preschool wheeze (PW) and at the revisit after 3 months (PW-R, n = 113/145) and 101 healthy controls (HC) aged 6–48 months in the GEWAC cohort using the antibody-mediated proximity extension-based assay (Olink Proteomics, Uppsala).ResultsOf the 74 analysed proteins, 52 were differentially expressed between PW and HC. The expression profiles of the top 10 proteins, Oncostatin M (OSM), IL-10, IL-6, Fibroblast growth factor 21 (FGF21), AXIN1, CXCL10, SIRT2, TNFSF11, Tumour necrosis factor β (TNF-β) and CASP8, could almost entirely separate PW from HC. Five out of 10 proteins were associated with intake of oral corticosteroids (OCS) 24 h preceding blood sampling (OSM, CASP8, IL-10, TNF-β and CXCL10). No differences in protein expression were seen between PWs with or without OCS in comparison to HC. At the revisit after 3 months, differential protein expressions were still seen between PW-R and HC for three (IL-10, SIRT2 and FGF21) of the 10 proteins.ConclusionOur results contribute to unravelling potential immunopathological pathways shared between preschool wheeze and asthma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- asthma
- inflammation
- olink
- plasma proteins
- preschool wheeze
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Holmdahl, Idun
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Chakraborty, San ...
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Hoyer, Angela
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Filiou, Anastasi ...
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Asarnoj, Anna
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Sjölander, Ander ...
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Borres, Magnus P ...
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van Hage, Marian ...
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Hedlin, Gunilla
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Konradsen, Jon R ...
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Söderhäll, Cilla
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Uppsala universitet
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