Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer

Vaccaro, AlessandraUppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi (author)

Of mice and lymphoid aggregates : modeling tertiary lymphoid structures in cancer

Tertiary lymphoid structures (TLS) are lymph node-like aggregates that can form in association with chronic inflammation or cancer. Mature TLS are organized into B and T cell zones, and are not encapsulated but include all cell types necessary for eliciting an adaptive immune response. TLS have been observed in various cancer types and are generally associated with a positive prognosis as well as increased sensitivity to cancer immunotherapy. However, a comprehensive understanding of the roles of TLS in eliciting anti-tumor immunity as well as the mechanisms involved in their formation and function is still lacking. Further studies in orthotopic, immunocompetent cancer models are necessary to evaluate the influence of TLS on cancer therapies, and to develop new treatments that promote their formation in cancer. Here, we review key insights obtained from functional murine studies, discuss appropriate models that can be used to study cancer-associated TLS, and suggest guidelines on how to identify TLS and distinguish them from other antigen-presenting niches.

van de Walle, TiarneUppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi,Cancerimmunterapi(Swepub:uu)tiava378 (author)
Ramachandran, Mohanraj,1988-Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,Cancerimmunterapi(Swepub:uu)mohra272 (author)
Essand, MagnusUppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerimmunterapi(Swepub:uu)magnessa (author)
Dimberg, AnnaUppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi(Swepub:uu)annadimb (author)
Uppsala universitetScience for Life Laboratory, SciLifeLab (creator_code:org_t)

By the author/editor: Vaccaro, Alessan ...; van de Walle, Ti ...; Ramachandran, Mo ...; Essand, Magnus; Dimberg, Anna

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

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