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A prospective study...
A prospective study showing long-term infection with human papillomavirus 16 before the development of cervical carcinoma in situ
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Ylitalo, Nathalie (author)
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- Josefsson, Agnetha (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Melbye, Mads (author)
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Sörensen, Per (author)
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Frisch, Morten (author)
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Andersen, Per Kragh (author)
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- Sparén, Pär (author)
- Karolinska Institutet
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Gustafsson, Margit (author)
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- Magnusson, Patrik (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Pontén, Jan (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Gyllensten, Ulf (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Adami, Hans-Olov (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2000
- 2000
- English.
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In: Cancer Research. - 0008-5472 .- 1538-7445. ; 60:21, s. 6027-6032
- Related links:
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
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- Human papillomavirus 16 (HPV16) is a predominant cause of cervical neoplasia. However, no population-based study with long-term follow-up has clarified the temporal relationship between HPV16 infection and occurrence of carcinoma in situ, or the importance of recurrent or persistent infection. This nested case-control study was carried out in a population-based cohort of women participating in cytological screening whose initial smear, taken in 1969-1995, was normal. During up to 26 years of follow-up, carcinoma in situ was diagnosed in 484 eligible women. Archival smears from these women were compared with smears from 619 individually matched controls. After DNA extraction, a highly sensitive PCR system was used to detect HPV16. Among case women, the prevalence of HPV16 positivity was 56% at the time of diagnosis. The relative risk of cervical carcinoma in situ increased from 3.6 (95% confidence interval, 1.2-11.0) 13 years before diagnosis to 11.1 (95% confidence interval, 5.5-22.2) 1 year before diagnosis. Having a positive smear at entry to the cohort increased risk >5-fold, whereas having persistent infection with HPV in two subsequent smears increased risk 30-fold. We estimated that among HPV16-positive women, the median incubation period from infection to carcinoma in situ was 7-12 years. We conclude that evidence of persistent and/or recurrent infection is associated with a drastically higher risk of cervical carcinoma in situ than occasional infection with HPV16.
Keyword
- Adolescent
- Adult
- Aged
- Carcinoma in Situ/epidemiology/*virology
- Carcinoma; Squamous Cell/epidemiology/*virology
- Case-Control Studies
- Cervix Neoplasms/epidemiology/*virology
- Cohort Studies
- Female
- Follow-Up Studies
- Humans
- Mass Screening
- Middle Aged
- Papillomavirus; Human
- Papovaviridae Infections/*complications/epidemiology/virology
- Prevalence
- Prospective Studies
- Research Support; Non-U.S. Gov't
- Research Support; U.S. Gov't; P.H.S.
- Risk Factors
- Sweden/epidemiology
- Time Factors
- Tumor Virus Infections/*complications/epidemiology/virology
- Vaginal Smears
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Ylitalo, Nathali ...
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Josefsson, Agnet ...
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Melbye, Mads
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Sörensen, Per
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Frisch, Morten
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Andersen, Per Kr ...
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show more...
-
Sparén, Pär
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Gustafsson, Marg ...
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Magnusson, Patri ...
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Pontén, Jan
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Gyllensten, Ulf
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Adami, Hans-Olov
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show less...
- Articles in the publication
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Cancer Research
- By the university
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Uppsala University
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Karolinska Institutet