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Diagnostic Values o...
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Liu, YuSun Yat sen Univ, Affiliated Hosp 7, Ctr Kidney & Urol, Dept Nephrol, Shenzhen 518107, Peoples R China.
(författare)
Diagnostic Values of METTL1-Related Genes and Immune Characteristics in Systemic Lupus Erythematosus
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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Dove Medical Press,2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-517510
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-517510URI
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https://doi.org/10.2147/JIR.S431628DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Purpose: Methyltransferase like 1 (METTL1) regulates epitranscriptomes via the m7G modification in mammalian mRNA and microRNA. Systemic lupus erythematosus (SLE) is caused by abnormal immune reactivity and has diverse clinical manifestations. RNA methylation as a mechanism to regulate gene expression is widely implicated in immune regulation. However, the role of m7G in immune response of SLE has not been extensively studied.Patients and Methods: Expression of METTL1 was identified in the public dataset GSE122459 and validated in an independent cohort of SLE patients. We investigated the association between METTL1-expression and clinical manifestations of SLE. Subsequently, differentially expressed genes (DEG) that were correlated with METTL1-expression in GSE122459 were used for functional enrichment analysis. The correlation between infiltrating immune cells and METTL1, as well as candidate biomarkers identified to be correlated with either METTL1 or immune cell infiltration were assessed by single-sample GSEA. Potential mechanisms were explored with Gene ontology and KEGG pathway enrichment. Diagnostic performances of candidate biomarkers in SLE were analyzed.Results: The mRNA and protein expression of METTL1 in SLE patients were significantly decreased in both datasets. METTL1-coexpressed DEGs were enriched in several key immune-related pathways. Activated CD8 T cells, activated CD4 T cells, memory B cells and type 2 helper T cells were different between patients with high and low METTL1 expression. Further, activated CD8 T-cells, activated CD4 T-cells, memory B-cells were correlated with METTL1. The genes of LAMP3, CD83, PDCD1LG2, IGKVD3D-20, IGKV5-2, IGKV2D-30, IGLV3-19 and IGLV4-60 were identified as candidate targets that were correlated with immune cell proportion. Moreover, LAMP3, CD83, and PDCD1LG2 expression were of diagnostic value in SLE as indicated by ROC analysis.Conclusion: Our findings suggested that METTL1 and its candidate targets LAMP3, CD83, PDCD1LG2 may be used for diagnosing SLE and could be explored for developing targeted molecular therapy for SLE.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Zhu, EnyiSun Yat sen Univ, Affiliated Hosp 7, Ctr Kidney & Urol, Dept Nephrol, Shenzhen 518107, Peoples R China.
(författare)
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Lei, YanSun Yat sen Univ, Affiliated Hosp 7, Ctr Kidney & Urol, Dept Nephrol, Shenzhen 518107, Peoples R China.
(författare)
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Luo, AilingGuangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangdong Prov Clin Res Ctr Child Hlth, Dept Hematol, Guangzhou 510623, Peoples R China.
(författare)
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Yan, YapingGuangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangdong Prov Clin Res Ctr Child Hlth, Dept Hematol, Guangzhou 510623, Peoples R China.
(författare)
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Cai, MansiGuangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangdong Prov Clin Res Ctr Child Hlth, Dept Hematol, Guangzhou 510623, Peoples R China.
(författare)
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Liu, ShanshanGuangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangdong Prov Clin Res Ctr Child Hlth, Dept Hematol, Guangzhou 510623, Peoples R China.
(författare)
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Huang, YanUniv South China, Affiliated Hosp 1, Hengyang Med Sch, Hengyang 421001, Peoples R China.
(författare)
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Guan, HuiSun Yat sen Univ, Affiliated Hosp 7, Ctr Kidney & Urol, Dept Nephrol, Shenzhen 518107, Peoples R China.
(författare)
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Zhong, MingSun Yat sen Univ, Affiliated Hosp 7, Ctr Kidney & Urol, Dept Nephrol, Shenzhen 518107, Peoples R China.
(författare)
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Li, WeinianSouth China Univ Technol, Guangzhou Peoples Hosp 1, Dept Rheumatol, Guangzhou 510623, Peoples R China.
(författare)
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Lin, LianSun Yat sen Univ, Affiliated Hosp 7, Ctr Kidney & Urol, Dept Nephrol, Shenzhen 518107, Peoples R China.
(författare)
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Hultström, Michael,1978-Uppsala universitet,Integrativ Fysiologi,Anestesiologi och intensivvård(Swepub:uu)mihul498
(författare)
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Lai, EnyinZhejiang Univ, Sch Basic Med Sci, Dept Physiol, Sch Med, Hangzhou 310058, Peoples R China.
(författare)
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Zheng, ZhihuaSun Yat sen Univ, Affiliated Hosp 7, Ctr Kidney & Urol, Dept Nephrol, Shenzhen 518107, Peoples R China.
(författare)
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Liu, XiaopingGuangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangdong Prov Clin Res Ctr Child Hlth, Dept Hematol, Guangzhou 510623, Peoples R China.
(författare)
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Tang, ChunSun Yat sen Univ, Affiliated Hosp 7, Ctr Kidney & Urol, Dept Nephrol, Shenzhen 518107, Peoples R China.
(författare)
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Sun Yat sen Univ, Affiliated Hosp 7, Ctr Kidney & Urol, Dept Nephrol, Shenzhen 518107, Peoples R China.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangdong Prov Clin Res Ctr Child Hlth, Dept Hematol, Guangzhou 510623, Peoples R China.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Inflammation Research: Dove Medical Press16, s. 5367-53831178-7031
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Liu, Yu
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Zhu, Enyi
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Lei, Yan
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Luo, Ailing
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Yan, Yaping
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Cai, Mansi
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visa fler...
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Liu, Shanshan
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Huang, Yan
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Guan, Hui
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Zhong, Ming
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Li, Weinian
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Lin, Lian
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Hultström, Micha ...
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Lai, Enyin
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Zheng, Zhihua
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Liu, Xiaoping
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Tang, Chun
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