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  • Afrakhte, MozhganUppsala universitet,Institutionen för genetik och patologi (author)

Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

  • Article/chapterEnglish1998

Publisher, publication year, extent ...

  • Elsevier BV,1998
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-51811
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-51811URI
  • https://doi.org/10.1006/bbrc.1998.9170DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Smad6 and Smad7 function as intracellular antagonists in transforming growth factor-beta (TGF-beta) signaling. Here we report the isolation of human Smad6, which is closely related to Smad7. Smad6 and Smad7 mRNAs were differentially expressed in lung cancer cell lines and were rapidly and directly induced by TGF-beta1, activin and bone morphogenetic protein-7. Cross-talk between TGF-beta and other signaling pathways was demonstrated by the finding that epidermal growth factor (EGF) induced the expression of inhibitory SMAD mRNA. Moreover, whereas the phorbol ester PMA alone had no effect, it potentiated the TGF-beta1-induced expression of Smad7 mRNA. Ectopic expression of anti-sense Smad7 RNA was found to increase the effect of TGF-beta1, supporting its role as a negative regulator in TGF-beta signaling. Thus, expression of inhibitory Smads is induced by multiple stimuli, including the various TGF-beta family members, whose action they antagonize.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Morén, AnitaUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)anitmore (author)
  • Jossan, SurinderUppsala universitet,Institutionen för genetik och patologi (author)
  • Itoh, SusumuUppsala universitet,Ludwiginstitutet för cancerforskning (author)
  • Sampath, Kuber (author)
  • Westermark, BengtUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)bengtwm (author)
  • Heldin, Carl-HenrikUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)carlheld (author)
  • Heldin, Nils-ErikUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)neheldin (author)
  • ten Dijke, PeterUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)pedij839 (author)
  • Uppsala universitetInstitutionen för genetik och patologi (creator_code:org_t)

Related titles

  • In:Biochemical and Biophysical Research Communications - BBRC: Elsevier BV249:2, s. 505-110006-291X1090-2104

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