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Higher fresh fruit ...
Higher fresh fruit intake relates to larger grey matter volumes in areas involved in dementia and depression : A UK Biobank study
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- Gaudio, Santino (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap,Via Pietro Tacchini 24, I-00197 Rome, Italy.
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- Rukh, Gull (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Di Ciommo, Vincenzo (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Berkins, Samuel (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Wiemerslage, Lyle (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Schiöth, Helgi B. (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap,Sechenov First Moscow State Med Univ, Inst Translat Med & Biotechnol, Moscow, Russia.
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: NeuroImage. - : Elsevier. - 1053-8119 .- 1095-9572. ; 283
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The benefits of consuming fruits and vegetables are widely accepted. While previous studies suggest a protective role of fruits and vegetables against a variety of diseases such as dementia and depression, the biological mechanisms/effects remain unclear. Here we investigated the effect of fruit and vegetable consumption on brain structure. Particularly on grey matter (GM) and white matter (WM) volumes, regional GM volumes and subcortical volumes. Cross-sectional imaging data from UK Biobank cohort was used. A total of 9925 participants (Mean age 62.4 +/- 7.5 years, 51.1 % men) were included in the present analysis. Measures included fruit and vegetable intake, other dietary patterns and a number of selected lifestyle factors and clinical data. Brain volumes were derived from structural brain magnetic resonance imaging. General linear model was used to study the associations between brain volumes and fruit/vegetable intakes. After adjusting for selected confounding factors, salad/raw vegetable intake showed a positive association with total white matter volume, fresh fruit intake showed a negative association with total grey matter (GM) volume. Regional GM analyses showed that higher fresh fruit intake was associated with larger GM volume in the left hippocampus, right temporal occipital fusiform cortex, left postcentral gyrus, right precentral gyrus, and right juxtapositional lobule cortex. We conclude that fruit and vegetable consumption seems to specifically modulate brain volumes. In particular, fresh fruit intake may have a protective role in specific cortical areas such as the hippocampus, areas robustly involved in the pathophysiology of dementia and depression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Fruit
- Vegetable
- Gray matter
- White matter
- Dementia
- Depression
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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