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Effect of controlle...
Effect of controlled hypotensive hemorrhage on plasma sodium levels in anesthetized pigs : An exploratory study
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- Krmar, Rafael T. (författare)
- Karolinska Institutet
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- Franzén, Stephanie (författare)
- Uppsala University,Uppsala universitet,Anestesiologi och intensivvård
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- Karlsson, Leif (författare)
- Karolinska Univ Hosp, Karolinska Inst, Dept Womens & Childrens Hlth, Pediat Endocrinol Unit, Stockholm, Sweden.,Karolinska University Hospital
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- Strandberg, Helin (författare)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Törnroth-Horsefield, Susanna (författare)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Andresen, Jesper K. (författare)
- Univ Southern Denmark, Inst Mol Med, Dept Cardiovasc & Renal Res, Odense, Denmark.;Odense Univ Hosp, Dept Urol, Odense, Denmark.,University of Southern Denmark,Odense University Hospital
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- Jensen, Boye L. (författare)
- Univ Southern Denmark, Inst Mol Med, Dept Cardiovasc & Renal Res, Odense, Denmark.;Odense Univ Hosp, Dept Urol, Odense, Denmark.,Odense University Hospital,University of Southern Denmark
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- Carlstrom, Mattias (författare)
- Karolinska Institutet
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- Frithiof, Robert (författare)
- Uppsala University,Uppsala universitet,Anestesiologi och intensivvård
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(creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- Engelska.
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Ingår i: Physiological Reports. - : John Wiley & Sons. - 2051-817X. ; 11:22
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Perioperative hyponatremia, due to non-osmotic release of the antidiuretic hormone arginine vasopressin, is a serious electrolyte disorder observed in connection with many types of surgery. Since blood loss during surgery contributes to the pathogenesis of hyponatremia, we explored the effect of bleeding on plasma sodium using a controlled hypotensive hemorrhage pig model. After 30-min baseline period, hemorrhage was induced by aspiration of blood during 30 min at mean arterial pressure <50 mmHg. Thereafter, the animals were resuscitated with retransfused blood and a near-isotonic balanced crystalloid solution and monitored for 180 min. Electrolyte and water balances, cardiovascular response, renal hemodynamics, and markers of volume regulation and osmoregulation were investigated. All pigs (n = 10) developed hyponatremia. All animals retained hypotonic fluid, and none could excrete net-free water. Urinary excretion of aquaporin 2, a surrogate marker of collecting duct responsiveness to antidiuretic hormone, was significantly reduced at the end of the study, whereas lysine vasopressin, i.e., the pig antidiuretic hormone remained high. In this animal model, hyponatremia developed due to net positive fluid balance and generation of electrolyte-free water by the kidneys. A decreased urinary aquaporin 2 excretion may indicate an escape from antidiuresis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- aquaporin 2
- hemorrhage
- hyponatremia
- pig model
- renin-angiotensin aldosterone
- vasopressin-neurophysin 2-copeptin
- aquaporin 2
- hemorrhage
- hyponatremia
- pig model
- renin-angiotensin aldosterone
- vasopressin-neurophysin 2-copeptin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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