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Intravenous S-ketam...
Intravenous S-ketamine's analgesic efficacy in third molar surgery : A randomized placebo-controlled double-blind clinical trial
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- Eriksson, Lars B. (author)
- Uppsala universitet,Odontologi & Maxillofacial kirurgi,Centrum för klinisk forskning Dalarna,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden;Centre for Clinical Research, Uppsala University, Falun, Sweden
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- Gordh, Torsten (author)
- Uppsala universitet,Klinisk smärtforskning,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden;Multidisciplinary Pain Centre, Uppsala University, Uppsala, Sweden
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- Karlsten, Rolf (author)
- Uppsala universitet,Klinisk smärtforskning,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden;Multidisciplinary Pain Centre, Uppsala University, Uppsala, Sweden
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- LoMartire, Riccardo (author)
- Uppsala universitet,Centrum för klinisk forskning Dalarna,Centre for Clinical Research, Uppsala University, Falun, Sweden
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- Thor, Andreas (author)
- Uppsala universitet,Odontologi & Maxillofacial kirurgi,Plastikkirurgi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden;Plastic & Oral and Maxillofacial Surgery, Uppsala University, Uppsala, Sweden
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- Tegelberg, Åke (author)
- Malmö universitet,Uppsala universitet,Centrum för klinisk forskning, Västerås,Department of Orofacial pain and jaw function, Faculty of Odontology, Malmö University, Malmö, Sweden,Odontologiska fakulteten (OD),Centre for Clinical Research, Uppsala University, Västerås, Sweden
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: British Journal of Pain. - : Sage Publications. - 2049-4637 .- 2049-4645.
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Abstract
Subject headings
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- BackgroundIn most cases, a combination of paracetamol and ibuprofen are the optimal treatment for postoperative pain in third molar surgery. If stronger analgesia is required, opioids are traditionally administered. In day-case, surgery; however, opioids should be avoided. Thus, the anaesthetic agent S-ketamine in analgesic doses might be preferred.MethodsThe study was designed as a randomized placebo-controlled double-blind clinical trial. The study enrolled healthy subjects according to the American Society of Anaesthesiologists classification; I or II (ASA), aged 18 to 44 years, with a body weight between 50 and 100 kg. The patients were randomized into three groups where two doses of S-ketamine were compared (high: 0.25 mg/kg or low: 0.125 mg/kg) with placebo (saline).ResultsA primary outcome of the study was that VAS at 4 h postoperatively, showed no significant difference between the placebo and high-dose S-ketamine group or in the low-dose group. We found a significant difference between the groups for the first 24 h, with a lower VAS-score in the high-dose S-ketamine group. The time to when 50% had taken their first rescue medication was 12 min later in the high-dose ketamine group.ConclusionsPre-emptive S-ketamine 0.25 mg/kg gave a global significant reduction of pain by VAS during the first 24 h postoperatively. The time from end of surgery to first rescue medication were longer in the high-dose ketamine group compared to both low-dose ketamine and placebo groups.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- S-Ketamine pain
- pain
- postoperative pain
- pain management
- intravenous
- sedation
- oral surgery
Publication and Content Type
- ref (subject category)
- art (subject category)
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