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Anaeramoebae are a ...
Anaeramoebae are a divergent lineage of eukaryotes that shed light on the transition from anaerobic mitochondria to hydrogenosomes
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- Stairs, Courtney W (författare)
- Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Mikrobiologigruppen,Forskargrupper vid Lunds universitet,Molecular Cell Biology,Department of Biology,Faculty of Science,Microbiology Group,Lund University Research Groups
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- Táborský, Petr (författare)
- Charles University in Prague
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- Salomaki, Eric D. (författare)
- Institute of Parasitology, Czech Academy of Sciences
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- Kolisko, Martin (författare)
- Institute of Parasitology, Czech Academy of Sciences
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- Pánek, Tomáš (författare)
- Charles University in Prague
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- Eme, Laura (författare)
- University of Paris-Saclay
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- Hradilová, Miluše (författare)
- Academy of Sciences of the Czech Republic
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- Vlček, Čestmír (författare)
- Academy of Sciences of the Czech Republic
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- Jerlström-Hultqvist, Jon, 1982- (författare)
- Department of Biochemistry and Molecular Biology, Dalhousie University, 5850 College St. Halifax, NS B3H 4R2, Canada
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- Roger, Andrew J. (författare)
- Dalhousie University
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- Čepička, Ivan (författare)
- Charles University in Prague
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Current Biology. - : Elsevier. - 0960-9822 .- 1879-0445. ; 31:24, s. 5605-5612.e5
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Abstract
Ämnesord
Stäng
- Discoveries of diverse microbial eukaryotes and their inclusion in comprehensive phylogenomic analyses have crucially re-shaped the eukaryotic tree of life in the 21st century.(1) At the deepest level, eukaryotic diversity comprises 9-10 "supergroups." One of these supergroups, the Metamonada, is particularly important to our understanding of the evolutionary dynamics of eukaryotic cells, including the remodeling of mitochondrial function. All metamonads thrive in low-oxygen environments and lack classical aerobic mitochondria, instead possessing mitochondrion-related organelles (MROs) with metabolisms that are adapted to low-oxygen conditions. These MROs lack an organellar genome, do not participate in the Krebs cycle and oxidative phosphorylation,(2) and often synthesize ATP by substrate-level phosphorylation coupled to hydrogen production.(3,4) The events that occurred during the transition from an oxygen-respiring mitochondrion to a functionally streamlined MRO early in metamonad evolution remain largely unknown. Here, we report transcriptomes of two recently described, enigmatic, anaerobic protists from the genus Anaeramoeba.(5) Using phylogenomic analysis, we show that these species represent a divergent, phylum-level lineage in the tree of metamonads, emerging as a sister group of the Parabasalia and reordering the deep branching order of the metamonad tree. Metabolic reconstructions of the Anaeramoeba MROs reveal many "classical" mitochondrial features previously not seen in metamonads, including a disulfide relay import system, propionate production, and amino acid metabolism. Our findings suggest that the cenancestor of Metamonada likely had MROs with more classical mitochondrial features than previously anticipated and demonstrate how discoveries of novel lineages of high taxonomic rank continue to transform our understanding of early eukaryote evolution.
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- mitochondria; protist; Parabasalia; phylogenomic; anaerobic metabolism; Metamonada; evolution; hydrogenosome; mitochondrial evolution
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Stairs, Courtney ...
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Táborský, Petr
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Salomaki, Eric D ...
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Kolisko, Martin
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Pánek, Tomáš
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Eme, Laura
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visa fler...
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Hradilová, Miluš ...
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Vlček, Čestmír
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Jerlström-Hultqv ...
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Roger, Andrew J.
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Čepička, Ivan
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visa färre...
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- NATURVETENSKAP
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NATURVETENSKAP
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NATURVETENSKAP
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Current Biology
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