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Isolated small airw...
Isolated small airways obstruction predicts future chronic airflow obstruction : a multinational longitudinal study
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Knox-Brown, Ben (author)
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Potts, James (author)
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Santofimio, Valentina Quintero (author)
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Minelli, Cosetta (author)
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Patel, Jaymini (author)
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Abass, Najlaa Mohammed (author)
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Agarwal, Dhiraj (author)
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Ahmed, Rana (author)
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Mahesh, Padukudru Anand (author)
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Bs, Jayaraj (author)
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Denguezli, Meriam (author)
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Franssen, Frits (author)
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Gislason, Thorarinn (author)
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- Janson, Christer (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
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Juvekar, Sanjay K (author)
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Koul, Parvaiz (author)
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- Malinovschi, Andrei, 1978- (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
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Nafees, Asaad Ahmed (author)
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Nielsen, Rune (author)
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Paraguas, Stefanni Nonna M (author)
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Buist, Sonia (author)
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Burney, Peter Gj (author)
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Amaral, Andre F S (author)
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(creator_code:org_t)
- BMJ Publishing Group Ltd, 2023
- 2023
- English.
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In: BMJ open respiratory research. - : BMJ Publishing Group Ltd. - 2052-4439. ; 10:1
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Chronic airflow obstruction is a key characteristic of chronic obstructive pulmonary disease. We investigated whether isolated small airways obstruction is associated with chronic airflow obstruction later in life.METHODS: We used longitudinal data from 3957 participants of the multinational Burden of Obstructive Lung Disease study. We defined isolated small airways obstruction using the prebronchodilator mean forced expiratory flow rate between 25% and 75% of the forced vital capacity (FVC) (FEF25-75) if a result was less than the lower limit of normal (1/FVC). We also used the forced expiratory volume in 3 s to FVC ratio (FEV3/FVC) to define small airways obstruction. We defined chronic airflow obstruction as post-bronchodilator FEV1/FVCRESULTS: Median follow-up time was 8.3 years. Chronic airflow obstruction was more likely to develop in participants with isolated small airways obstruction at baseline (FEF25-75 less than the LLN, OR: 2.95, 95% CI 1.02 to 8.54; FEV3/FVC less than the LLN, OR: 1.94, 95% CI 1.05 to 3.62). FEF25-75 was better than the FEV3/FVC ratio to discriminate future chronic airflow obstruction (AUC: 0.764 vs 0.692). Results were similar among participants of the UK Biobank study.CONCLUSION: Measurements of small airways obstruction can be used as early markers of future obstructive lung disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- COPD epidemiology
- Lung Physiology
- Lungmedicin
- Lung Medicine
- Clinical Physiology
- Klinisk fysiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Knox-Brown, Ben
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Potts, James
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Santofimio, Vale ...
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Minelli, Cosetta
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Patel, Jaymini
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Abass, Najlaa Mo ...
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show more...
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Agarwal, Dhiraj
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Ahmed, Rana
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Mahesh, Padukudr ...
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Bs, Jayaraj
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Denguezli, Meria ...
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Franssen, Frits
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Gislason, Thorar ...
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Janson, Christer
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Juvekar, Sanjay ...
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Koul, Parvaiz
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Malinovschi, And ...
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Nafees, Asaad Ah ...
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Nielsen, Rune
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Paraguas, Stefan ...
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Buist, Sonia
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Burney, Peter Gj
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Amaral, Andre F ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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BMJ open respira ...
- By the university
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Uppsala University