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  • Odell, Luke R.Uppsala universitet,Institutionen för läkemedelskemi (author)

Synthesis of Substituted Indazole Acetic Acids by N-N Bond Forming Reactions

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Wiley-Blackwell,2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-519647
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-519647URI
  • https://doi.org/10.1002/ejoc.202300291DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:152626107URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Herein, we report on the discovery and development of novel cascade N-N bond forming reactions for the synthesis of rare indazole acetic acid scaffolds. This approach allows for convenient synthesis of three distinct indazole acetic acid derivatives (unsubstituted, hydroxy, and alkoxy) by heating 3-amino-3-(2-nitroaryl)propanoic acids with an appropriate nucleophile/solvent under basic conditions. The reaction tolerates a range of functional groups and electronic effects and, in total, 23 novel indazole acetic acids were synthesized and characterized. This work offers a valuable strategy for the synthesis of useful scaffolds for drug discovery programs.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Skillinghaug, BoboUppsala universitet,Institutionen för läkemedelskemi(Swepub:uu)bobsk501 (author)
  • Matt, ChristofUppsala universitet,Preparativ läkemedelskemi(Swepub:uu)chrma538 (author)
  • Wu, PengUppsala universitet,Institutionen för läkemedelskemi (author)
  • Koolmeister, TobiasKarolinska Inst, Sci Life Lab, Dept Oncol Pathol, S-17176 Stockholm, Sweden. (author)
  • Desroses, MatthieuKarolinska Inst, Sci Life Lab, Dept Oncol Pathol, S-17176 Stockholm, Sweden. (author)
  • Llona-Minguez, SabinKarolinska Inst, Sci Life Lab, Dept Oncol Pathol, S-17176 Stockholm, Sweden. (author)
  • Wallner, OlovKarolinska Institutet,Karolinska Inst, Sci Life Lab, Dept Oncol Pathol, S-17176 Stockholm, Sweden. (author)
  • Helleday, ThomasKarolinska Inst, Sci Life Lab, Dept Oncol Pathol, S-17176 Stockholm, Sweden. (author)
  • Scobie, MartinKarolinska Inst, Sci Life Lab, Dept Oncol Pathol, S-17176 Stockholm, Sweden. (author)
  • Uppsala universitetInstitutionen för läkemedelskemi (creator_code:org_t)

Related titles

  • In:European Journal of Organic Chemistry: Wiley-Blackwell26:291434-193X1099-0690

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