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Clinically relevant...
Clinically relevant increases in serum neurofilament light chain and glial fibrillary acidic protein in patients with Susac syndrome
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- Plantone, Domenico (författare)
- Univ Siena, Dept Med Surg & Neurosci, Siena, Italy.;Univ Siena, Dept Med Surg & Neurosci, Viale Bracci 2, I-53100 Siena, Italy.
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- Sabatelli, Eleonora (författare)
- Fdn Policlin Univ A Gemelli IRCCS, Neurol Unit, Rome, Italy.
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- Locci, Sara (författare)
- Univ Siena, Dept Med Surg & Neurosci, Siena, Italy.
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- Marrodan, Mariano (författare)
- Fleni, Neurol Dept, Buenos Aires, Argentina.
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- Laakso, Sini M. (författare)
- Univ Helsinki, Clin Neurosci Neurol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Univ Helsinki, Fac Med, Translat Immunol Res Program, Helsinki, Finland.
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- Mateen, Farrah J. (författare)
- Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA.
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- Feresiadou, Amalia (författare)
- Uppsala universitet,Neurologi,Uppsala Univ Hosp, Dept Neurol, Uppsala, Sweden.
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- Buelens, Tom (författare)
- CHU St Pierre & Brugmann, Dept Ophthalmol, Brussels, Belgium.
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- Bianco, Assunta (författare)
- Fdn Policlin Univ A Gemelli IRCCS, Neurol Unit, Rome, Italy.
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- Fiol, Marcela P. (författare)
- Fleni, Neurol Dept, Buenos Aires, Argentina.
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- Correale, Jorge (författare)
- Fleni, Neurol Dept, Buenos Aires, Argentina.;Univ Buenos Aires, Inst Biol Chem & Biophys IQUIFIB CONICET, Buenos Aires, Argentina.
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- Tienari, Pentti (författare)
- Helsinki Univ Hosp, Dept Neurol, Neuroctr, Helsinki, Finland.;Univ Helsinki, Fac Med, Res Program Translat Immunol, Helsinki, Finland.
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- Calabresi, Paolo (författare)
- Fdn Policlin Univ A Gemelli IRCCS, Neurol Unit, Rome, Italy.;Univ Cattolica Sacro Cuore, Dept Neurosci, Rome, Italy.
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- De Stefano, Nicola (författare)
- Univ Siena, Dept Med Surg & Neurosci, Siena, Italy.
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- Iorio, Raffaele (författare)
- Fdn Policlin Univ A Gemelli IRCCS, Neurol Unit, Rome, Italy.;Univ Cattolica Sacro Cuore, Dept Neurosci, Rome, Italy.;Univ Cattolica Sacro Cuore, Dept Neurosci, L go Gemelli 1, I-00135 Rome, Italy.
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Univ Siena, Dept Med Surg & Neurosci, Siena, Italy;Univ Siena, Dept Med Surg & Neurosci, Viale Bracci 2, I-53100 Siena, Italy. Fdn Policlin Univ A Gemelli IRCCS, Neurol Unit, Rome, Italy. (creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- Engelska.
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Ingår i: European Journal of Neurology. - : John Wiley & Sons. - 1351-5101 .- 1468-1331. ; 30:10, s. 3256-3264
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and purpose: Serum levels of neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are promising neuro-axonal damage and astrocytic activation biomarkers. Susac syndrome (SS) is an increasingly recognized neurological condition and biomarkers that can help assess and monitor disease evolution are highly needed for the adequate management of these patients. sNfL and sGFAP levels were evaluated in patients with SS and their clinical relevance in the relapse and remission phase of the disease was assessed. Methods: As part of a multicentre study that enrolled patients diagnosed with SS from six international centres, sNfL and sGFAP levels were assessed in 22 SS patients (nine during a relapse and 13 in remission) and 59 age-and sex-matched healthy controls using SimoaTM assay Neurology 2-Plex B Kit. Results: Serum NfL levels were higher than those of healthy controls (p < 0.001) in SS patients and in both subgroups of patients in relapse and in remission (p < 0.001 for both), with significantly higher levels in relapse than in remission (p = 0.008). sNfL levels showed a negative correlation with time from the last relapse (r = -0.663; p = 0.001). sGFAP levels were slightly higher in the whole group of patients than in healthy controls (p = 0.046) and were more pronounced in relapse than in remission (p = 0.013). Conclusion: In SS patients, both sNFL and sGFAP levels increased compared with healthy controls. Both biomarkers had higher levels during clinical relapse and much lower levels in remission. sNFL was shown to be time sensitive to clinical changes and can be useful to monitor neuro-axonal damage in SS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- biomarkers
- inflammation
- neuro-ophthalmology
- neuro-otology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Plantone, Domeni ...
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Sabatelli, Eleon ...
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Locci, Sara
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Marrodan, Marian ...
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Laakso, Sini M.
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Mateen, Farrah J ...
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visa fler...
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Feresiadou, Amal ...
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Buelens, Tom
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Bianco, Assunta
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Fiol, Marcela P.
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Correale, Jorge
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Tienari, Pentti
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Calabresi, Paolo
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De Stefano, Nico ...
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Iorio, Raffaele
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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European Journal ...
- Av lärosätet
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Uppsala universitet