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Local and Systemic ...
Local and Systemic Immunity During Five Vaccinations Against SARS-CoV-2 in Zanubrutinib-Treated Patients With Chronic Lymphocytic Leukemia
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- Andersson, Maria (författare)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp Solna, Dept Hematol, Stockholm, Sweden.
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- Wu, Jinghua (författare)
- Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden.
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- Wullimann, David (författare)
- Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden.
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- Gao, Yu (författare)
- Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden.
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- Åberg, Mikael (författare)
- Uppsala universitet,Klinisk kemi,Science for Life Laboratory, SciLifeLab
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- Muschiol, Sandra (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden.;Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
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- Healy, Katie (författare)
- Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden.
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- Naud, Sabrina (författare)
- Karolinska Inst, Dept Dent Med, Huddinge, Sweden.
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- Bogdanovic, Gordana (författare)
- Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden.;Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
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- Palma, Marzia (författare)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp Solna, Dept Hematol, Stockholm, Sweden.
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- Mellstedt, Hakan (författare)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
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- Chen, Puran (författare)
- Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden.
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- Ljunggren, Hans-Gustaf (författare)
- Karolinska Institutet,Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden.
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- Hansson, Lotta (författare)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp Solna, Dept Hematol, Stockholm, Sweden.
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- Sallberg Chen, Margaret (författare)
- Karolinska Institutet,Karolinska Inst, Dept Dent Med, Huddinge, Sweden.
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- Buggert, Marcus (författare)
- Karolinska Institutet,Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden.
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- Ingelman-Sundberg, Hanna M. (författare)
- Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp Solna, Dept Oncol, Stockholm, Sweden.;Karolinska Univ, Hosp Solna, Dept Oncol, SE-17176 Stockholm, Sweden.
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- Osterborg, Anders (författare)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp Solna, Dept Hematol, Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden;Karolinska Univ Hosp Solna, Dept Hematol, Stockholm, Sweden. (creator_code:org_t)
- Elmer Press, Inc. 2023
- 2023
- Engelska.
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Ingår i: Journal of Hematology. - : Elmer Press, Inc.. - 1927-1212 .- 1927-1220. ; 12:4, s. 170-175
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Patients with chronic lymphocytic leukemia (CLL) are vulnerable to coronavirus disease 2019 (COVID-19) and are at risk of inferior response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, especially if treated with the first-generation Bruton’s tyrosine kinase inhibitor (BTKi) ibrutinib. We aimed to evaluate the impact of the third-generation BTKi, zanubrutinib, on systemic and mucosal response to SARS-CoV-2 vaccination.Methods: Nine patients with CLL with ongoing zanubrutinib therapy were included and donated blood and saliva during SARS-CoV-2 vaccination, before vaccine doses 3 and 5 and 2 - 3 weeks after doses 3, 4, and 5. Ibrutinib-treated control patients (n = 7) and healthy aged-matched controls (n = 7) gave blood 2 - 3 weeks after vaccine dose 5. We quantified reactivity and neutralization capacity of SARS-CoV-2-specific IgG and IgA antibodies (Abs) in both serum and saliva, and reactivity of T cells activated with viral peptides.Results: Both zanubrutinib- and ibrutinib-treated patients had significantly, up to 1,000-fold, lower total spike-specific Ab levels after dose 5 compared to healthy controls (P < 0.01). Spike-IgG levels in serum from zanubrutinib-treated patients correlated well to neutralization capacity (r = 0.68; P < 0.0001) and were thus functional. Mucosal immunity (specific IgA in serum and saliva) was practically absent in zanubrutinib-treated patients even after five vaccine doses, whereas healthy controls had significantly higher levels (tested in serum after vaccine dose 5) (P < 0.05). In contrast, T-cell reactivity against SARS-CoV-2 peptides was equally high in zanubrutinib- and ibrutinib-treated patients as in healthy control donors.Conclusions: In our small cohort of zanubrutinib-treated CLL patients, we conclude that up to five doses of SARS-CoV-2 vaccination induced no detectable IgA mucosal immunity, which likely will impair the primary barrier defence against the infection. Systemic IgG responses were also impaired, whereas T-cell responses were normal. Further and larger studies are needed to evaluate the impact of these findings on disease protection.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- CLL
- Zanubrutinib
- SARS-CoV-2
- Immunity
- Vaccination
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- ref (ämneskategori)
- art (ämneskategori)
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Andersson, Maria
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Wu, Jinghua
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Wullimann, David
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Gao, Yu
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Åberg, Mikael
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Muschiol, Sandra
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visa fler...
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Healy, Katie
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Naud, Sabrina
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Bogdanovic, Gord ...
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Palma, Marzia
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Mellstedt, Hakan
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Chen, Puran
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Ljunggren, Hans- ...
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Hansson, Lotta
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Sallberg Chen, M ...
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Buggert, Marcus
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Ingelman-Sundber ...
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Osterborg, Ander ...
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