Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Marklund M.) > Omega-3 Blood Level...

Details
MARC

O'Keefe, James H. (author)

Omega-3 Blood Levels and Stroke Risk : A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies

Article/chapterEnglish2024

Publisher, publication year, extent ...

American Heart Association,2024
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-520257
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-520257URI
https://doi.org/10.1161/STROKEAHA.123.044281DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:154636157URI
https://urn.kb.se/resolve?urn=urn:nbn:se:du-47667URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:238134264URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:155127405URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

BACKGROUND:The effect of marine omega-3 PUFAs on risk of stroke remains unclear.METHODS:We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome.RESULTS:Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76–0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74–0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81–0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78–0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD.CONCLUSIONS:Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
atrial fibrillation
cerebrovascular disease
fish
fish oil
stroke

Added entries (persons, corporate bodies, meetings, titles ...)

Lind, LarsUppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind (author)
Harris, William S. (author)
O'Keefe, Evan L.Karolinska Institutet (author)
Sala-Vila, Aleix (author)
Attia, John (author)
Garg, G. Manohar (author)
Hure, Alexis (author)
Sørensen Bork, Christian (author)
Berg Schmidt, Erik (author)
Krogh Venø, Stine (author)
Chien, Kuo-Liong (author)
Chen, Yun-Yu Amelia (author)
Egert, Sarah (author)
Rudholm Feldreich, TobiasHögskolan Dalarna,Medicinsk vetenskap(Swepub:du)trf (author)
Ärnlöv, Johan,1970-Karolinska insitutet(Swepub:du)jan (author)
Lind, LarsUppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind (author)
Forouhi, Nita G. (author)
Marklund, MattiUppsala universitet,Klinisk nutrition och metabolism,The George Institute for Global Health, University of New South Wales, Newtown, Australia; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA(Swepub:uu)matma701 (author)
Pertiwi, Kamalita (author)
Imamura, Fumiaki (author)
de Mello Laaksonen, Vanessa (author)
Uusitupa, W. Matti (author)
Tuomilehto, Jaakko (author)
Laakso, Markku (author)
Lankinen, Maria Anneli (author)
Laurin, Danielle (author)
Carmichael, Pierre-Hugues (author)
Lindsay, Joan (author)
Leander, Karin (author)
Laguzzi, Federica (author)
Swenson, Brenton R. (author)
Longstreth, William T. (author)
Manson, JoAnn E. (author)
Mora, Samia (author)
Cook, Nancy R. (author)
Marklund, MattiUppsala universitet,Klinisk nutrition och metabolism,The George Institute for Global Health, University of New South Wales, Newtown, Australia; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA(Swepub:uu)matma701 (author)
Melo van Lent, Debora (author)
Murphy, Rachel (author)
Gudnason, Vilmundur (author)
Ninomiya, Toshihara (author)
Hirakawa, Yoichiro (author)
Qian, Frank (author)
Sun, Qi (author)
Hu, Frank (author)
Ardisson Korat, Andres V. (author)
Risérus, Ulf,1967-Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser (author)
Lázaro, Iolanda (author)
Samieri, Cecilia (author)
Le Goff, Mélanie (author)
Helmer, Catherine (author)
Steur, Marinka (author)
Voortman, Trudy (author)
Ikram, M. Kamran (author)
Tanaka, Toshiko (author)
Das, Jayanta K. (author)
Ferrucci, Luigi (author)
Bandinelli, Stefania (author)
Tsai, Michael (author)
Guan, Weihua (author)
Garg, Parveen (author)
Verschuren, W. M. Monique (author)
Boer, Jolanda M. A. (author)
Biokstra, Anneke (author)
Virtanen, Jyrki (author)
Wagner, Michael (author)
Westra, Jason (author)
Albuisson, Luc (author)
Yamagishi, Kazumasa (author)
Siscovick, David S. (author)
Lemaitre, Rozenn N. (author)
Mozaffarian, Dariush (author)
Uppsala universitetKlinisk epidemiologi (creator_code:org_t)

Related titles

In:Stroke: American Heart Association55:1, s. 50-580039-24991524-4628

Internet link

Find in a library

Stroke (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: O'Keefe, James H ...; Lind, Lars; Harris, William ...; O'Keefe, Evan L.; Sala-Vila, Aleix; Attia, John; show more...; Garg, G. Manohar; Hure, Alexis; Sørensen Bork, C ...; Berg Schmidt, Er ...; Krogh Venø, Stin ...; Chien, Kuo-Liong; Chen, Yun-Yu Ame ...; Egert, Sarah; Rudholm Feldreic ...; Ärnlöv, Johan, 1 ...; Forouhi, Nita G.; Marklund, Matti; Pertiwi, Kamalit ...; Imamura, Fumiaki; de Mello Laakson ...; Uusitupa, W. Mat ...; Tuomilehto, Jaak ...; Laakso, Markku; Lankinen, Maria ...; Laurin, Danielle; Carmichael, Pier ...; Lindsay, Joan; Leander, Karin; Laguzzi, Federic ...; Swenson, Brenton ...; Longstreth, Will ...; Manson, JoAnn E.; Mora, Samia; Cook, Nancy R.; Melo van Lent, D ...; Murphy, Rachel; Gudnason, Vilmun ...; Ninomiya, Toshih ...; Hirakawa, Yoichi ...; Qian, Frank; Sun, Qi; Hu, Frank; Ardisson Korat, ...; Risérus, Ulf, 19 ...; Lázaro, Iolanda; Samieri, Cecilia; Le Goff, Mélanie; Helmer, Catherin ...; Steur, Marinka; Voortman, Trudy; Ikram, M. Kamran; Tanaka, Toshiko; Das, Jayanta K.; Ferrucci, Luigi; Bandinelli, Stef ...; Tsai, Michael; Guan, Weihua; Garg, Parveen; Verschuren, W. M ...; Boer, Jolanda M. ...; Biokstra, Anneke; Virtanen, Jyrki; Wagner, Michael; Westra, Jason; Albuisson, Luc; Yamagishi, Kazum ...; Siscovick, David ...; Lemaitre, Rozenn ...; Mozaffarian, Dar ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

Articles in the publication: Stroke

By the university: Uppsala University; Karolinska Institutet; Högskolan Dalarna

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se