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Sökning: WFRF:(Paula André) > (2020-2024) > CD8+Treg cells play...

CD8+Treg cells play a role in the obesity-associated insulin resistance

Barbosa, Pedro (författare)
Univ Coimbra, Inst Interdisciplinary Res, Doctoral Programme Expt Biol & Biomed PDBEB, Coimbra, Portugal.;Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Inst Interdisciplinary Res IIIUC, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.
Pinho, Aryane (författare)
Univ Coimbra, Inst Interdisciplinary Res, Doctoral Programme Expt Biol & Biomed PDBEB, Coimbra, Portugal.;Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Inst Interdisciplinary Res IIIUC, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.;Univ Coimbra, Dept Life Sci, P-3000456 Coimbra, Portugal.
Lazaro, Andre (författare)
Ctr Hosp & Univ Coimbra, Gen Surg Unit, P-3000075 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med FMUC, Grp Environm Genet Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.
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Rosendo-Silva, Daniela (författare)
Univ Coimbra, Inst Interdisciplinary Res IIIUC, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med FMUC, Grp Environm Genet Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med, P-3000548 Coimbra, Portugal.
Paula, Diogo (författare)
Univ Coimbra, Dept Life Sci, P-3000456 Coimbra, Portugal.;Ctr Hosp & Univ Coimbra, Gen Surg Unit, P-3000075 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3000061 Coimbra, Portugal.
Campos, Jose (författare)
Ctr Hosp & Univ Coimbra, Gen Surg Unit, P-3000075 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3000061 Coimbra, Portugal.
Tralhao, Jose G. (författare)
Ctr Hosp & Univ Coimbra, Gen Surg Unit, P-3000075 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3000061 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med FMUC, Grp Environm Genet Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.;Univ Coimbra, Inst Biophys, Fac Med, P-3000548 Coimbra, Portugal.
Pereira, Maria J., 1981- (författare)
Uppsala universitet,Klinisk diabetologi och metabolism
Paiva, Artur (författare)
Univ Coimbra, Inst Interdisciplinary Res IIIUC, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.;Ctr Hosp & Univ Coimbra, Gen Surg Unit, P-3000075 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3000061 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med FMUC, Grp Environm Genet Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.;Ctr Hosp & Univ Coimbra, Dept Clin Pathol, Flow Cytometry Unit, P-3000076 Coimbra, Portugal.;ESTESC Coimbra Hlth Sch, Inst Politecn Coimbra, Ciencias Biomed Lab, P-3046854 Coimbra, Portugal.
Laranjeira, Paula (författare)
Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3000061 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med FMUC, Grp Environm Genet Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.;Ctr Hosp & Univ Coimbra, Dept Clin Pathol, Flow Cytometry Unit, P-3000076 Coimbra, Portugal.;Ctr Hosp & Univ Coimbra, Unidade Func Citometria Fluxo, Ave Bissaya Barreto,Bloco Hosp Celas 205, P-3000076 Coimbra, Portugal.
Carvalho, Eugenia (författare)
Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Inst Interdisciplinary Res IIIUC, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.;Univ Coimbra, Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal.
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Univ Coimbra, Inst Interdisciplinary Res, Doctoral Programme Expt Biol & Biomed PDBEB, Coimbra, Portugal;Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Inst Interdisciplinary Res IIIUC, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal. Univ Coimbra, Inst Interdisciplinary Res, Doctoral Programme Expt Biol & Biomed PDBEB, Coimbra, Portugal.;Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Inst Interdisciplinary Res IIIUC, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.;Univ Coimbra, Dept Life Sci, P-3000456 Coimbra, Portugal. (creator_code:org_t)
Elsevier, 2024
2024
Engelska.
Ingår i: Life Sciences. - : Elsevier. - 0024-3205 .- 1879-0631. ; 336
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Obesity-related chronic low-grade inflammation may trigger insulin resistance and type 2 diabetes (T2D) development. Cells with regulatory phenotype have been shown to be reduced during obesity, especially CD4+ Treg cells. However, little is known about the CD8+ Treg cells. Therefore, we aim to characterize the CD8+ Treg cells in human peripheral blood and adipose tissue, specifically, to address the effect of obesity and insulin resistance in this regulatory immune cell population. A group of 42 participants with obesity (OB group) were recruited. Fourteen of them were evaluated pre-and post-bariatric surgery. A group of age-and sex-matched healthy volunteers (n = 12) was also recruited (nOB group). CD8+ Treg cell quantification and phenotype were evaluated by flow cytometry, in peripheral blood (PB), subcutaneous (SAT), and visceral adipose tissues (VAT). The OB group displayed a higher percentage of CD8+ Treg cells in PB, compared to the nOB. In addition, they were preferentially polarized into Tc1-and Tc1/17-like CD8+ Treg cells, compared to nOB. Moreover, SAT displayed the highest content of CD8+ Tregs infiltrated, compared to PB or VAT, while CD8+ Tregs infiltrating VAT displayed a higher percentage of cells with Tc1-like phenotype. Participants with pre-diabetes displayed a reduced percentage of TIM-3+CD8+ Tregs in circulation, and PD-1+CD8+ Tregs infiltrated in the VAT. An in-crease in the percentage of circulating Tc1-like CD8+ Treg cells expressing PD-1 was observed post-surgery. In conclusion, obesity induces significant alterations in CD8+ Treg cells, affecting their percentage and phenotype, as well as the expression of important immune regulatory molecules.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Nyckelord

Regulatory T cells
Type 2 diabetes
Immune-checkpoints
Bariatric surgery
Low-grade inflammation
Obesity

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