id:"swepub:oai:DiVA.org:uu-521111"
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- Vyakaranam, Achyut RamUppsala universitet,Radiologi (författare)
Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes.
- Artikel/kapitelEngelska2024
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- 2024
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- LIBRIS-ID:oai:DiVA.org:uu-521111
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-521111URI
- https://doi.org/10.1007/s00125-023-06039-7DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
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- AIMS/HYPOTHESIS: Compromised pancreatic sympathetic innervation has been suggested as a factor involved in both immune-mediated beta cell destruction and endocrine dysregulation of pancreatic islets. To further explore these intriguing findings, new techniques for in vivo assessment of pancreatic innervation are required. This is a retrospective study that aimed to investigate whether the noradrenaline (norepinephrine) analogue 11C-hydroxy ephedrine (11C-HED) could be used for quantitative positron emission tomography (PET) imaging of the sympathetic innervation of the human pancreas.METHODS: In 25 individuals with type 2 diabetes and 64 individuals without diabetes, all of whom had previously undergone 11C-HED-PET/CT because of pheochromocytoma or paraganglioma (or suspicion thereof), the 11C-HED standardised uptake value (SUVmean), 11C-HED specific binding index (SBI), pancreatic functional volume (FV, in ml), functional neuronal volume (FNV, calculated as SUVmean × FV), specific binding index with functional volume (SBI FV, calculated as SBI × FV) and attenuation on CT (HU) were investigated in the entire pancreas, and additionally in six separate anatomical pancreatic regions.RESULTS: Generally, 11C-HED uptake in the pancreas was high, with marked individual variation, suggesting variability in sympathetic innervation. Moreover, pancreatic CT attenuation (HU) (p<0.001), 11C-HED SBI (p=0.0049) and SBI FV (p=0.0142) were lower in individuals with type 2 diabetes than in individuals without diabetes, whereas 11C-HED SUVmean (p=0.15), FV (p=0.73) and FNV (p=0.30) were similar.CONCLUSIONS/INTERPRETATION: We demonstrate the feasibility of using 11C-HED-PET for non-invasive assessment of pancreatic sympathetic innervation in humans. These findings warrant further prospective evaluation, especially in individuals with theoretical defects in pancreatic sympathetic innervation, such as those with type 1 diabetes.
Ämnesord och genrebeteckningar
- 11C-HED
- 11C-hydroxy ephedrine
- A41
- Diabetes
- Innervation
- PET-CT specific binding index
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Mahamed, Maryama M (författare)
- Hellman, Per (författare)
- Eriksson, Olof (författare)
- Espes, Daniel (författare)
- Christoffersson, Gustaf (författare)
- Sundin, AndersUppsala universitet,Radiologi(Swepub:uu)anderssu (författare)
- Uppsala universitetRadiologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Diabetologia67:1, s. 199-2080012-186X1432-0428
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