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Outcome prediction by myocardial external efficiency from 11C-acetate positron emission tomography in cardiac amyloidosis
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- Rosengren, Sara (författare)
- Uppsala universitet,Hematologi
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Skibsted Clemmensen, Tor (författare)
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Hvitfeldt Poulsen, Steen (författare)
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Tolbod, Lars (författare)
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Harms, Hendrik J. (författare)
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- Wikström, Gerhard (författare)
- Uppsala universitet,Kardiologi
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- Kero, Tanja (författare)
- Uppsala universitet,Radiologi
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Thyrsted Ladefoged, Bertil (författare)
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- Sörensen, Jens (författare)
- Uppsala universitet,Radiologi,Department of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, Denmark
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(creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
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Ingår i: ESC Heart Failure. - : John Wiley & Sons. - 2055-5822. ; 11:1, s. 44-53
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- AimsThis study aimed to study the prognostic value of myocardial oxygen consumption (MVO2) and myocardial external efficiency (MEE) from 11C-acetate positron emission tomography (PET) in cardiac amyloidosis (CA) patients.Methods and resultsForty-eight CA patients, both transthyretin (ATTR) and immunoglobulin light chain (AL) amyloidosis, and 20 controls were included. All subjects were examined with 11C-acetate PET and echocardiography. MVO2, forward stroke volume (FSV), and left ventricular mass (LVM) were derived from 11C-acetate PET and used to calculate MEE. CA patients were followed for survival and the prognostic impact of clinical, echocardiographic, and 11C-acetate PET parameters was analysed. MVO2 and MEE were reduced in CA compared with controls, but without significant difference between deceased and surviving CA patients. The ratio of 11C-acetate PET-derived FSV and LVM was also reduced in CA and significantly lowered in deceased patients compared with survivors. In univariate analysis, New York Heart Association class, N-terminal pro-brain natriuretic peptide, and the 11C-acetate PET parameters FSV/LVM and MEE were the strongest prognostic factors. Of the 11C-acetate PET parameters, FSV/LVM was the strongest survival predictor with hazard ratio of 0.56 per 0.1 mL/g (95% confidence interval 0.39–0.81, P = 0.002) and independently prognostic in a multivariate model. MEE significantly separated deceased from surviving CA patients with the cut-off of 15.7% (P = 0.032). Survival was significantly shorter with FSV/LVM below 0.27 mL/g (P < 0.001), also when separating AL- and ATTR-CA.ConclusionsReduced MEE was associated with shorter survival in CA patients, but FSV/LVM was the strongest survival predictor and the only independently prognostic 11C-acetate PET parameter in multivariate analysis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Acetate
- Heart
- Myocardial contraction fraction
- PET
- Prognosis
- Survival
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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